Osteoporosis in patients with end-stage lung disease
- Authors: Kochetkova E.A.1, Massard Z.1, Kessler R2, Maystrovskaya Y.V2, Kochetkova EA3, Massard G3, Kessler R3, Maistrovskaya Y.V4
-
Affiliations:
- Университетская больница
- Владивостокский государственный медицинский университет
- University Hospital, Strasbourg, France
- Vladivostok State Medical University
- Issue: Vol 82, No 5 (2010)
- Pages: 61-64
- Section: Editorial
- URL: https://journals.rcsi.science/0040-3660/article/view/30614
- ID: 30614
Cite item
Full Text
Abstract
Materials and methods. Sixty-five case histories were retrospectively analyzed in patients with ESLD who were to undergo lung transplantation. BMD in the lumbar spine (LS) and femoral neck (FN) was estimated by dual-energy X-ray absorptiometry. External respiratory function was investigated; gasometry and six-minute walk test (SMWT) were carried out.
Results. Osteopenic syndrome was recorded in 89% of the patients. Normal LS and FN BMD was found only in 7 (11%) patients. T-scores (in both LII-LIV and FN) were directly related to the body mass index. There was a direct correlation of BMD with forced expiratory volume in one second and an inverse correction with arterial blood pCO2. There was no significant relationship between the results of SMWT and BMD in both LII-LIV.
Conclusion. Osteoporosis is a common severe systemic manifestation in patients with ESLD.
About the authors
Evgeniya Anatol'evna Kochetkova
Университетская больница
Email: zhochetkova@mail.ru
д-р мед. наук, проф., медицинский фак. Страсбургского Университета, телефон: 0033-6-31-05-92-61, 0033-6-82-62-42-41; Университетская больница
Zh Massard
Университетская больницаУниверситетская больница
R Kessler
Владивостокский государственный медицинский университетВладивостокский государственный медицинский университет
Yu V Maystrovskaya
Владивостокский государственный медицинский университетВладивостокский государственный медицинский университет
E A Kochetkova
University Hospital, Strasbourg, FranceUniversity Hospital, Strasbourg, France
G Massard
University Hospital, Strasbourg, FranceUniversity Hospital, Strasbourg, France
R Kessler
University Hospital, Strasbourg, FranceUniversity Hospital, Strasbourg, France
Yu V Maistrovskaya
Vladivostok State Medical UniversityVladivostok State Medical University
References
- Rutherford R. M., Fisher A. J., Hilton C. et al. Functional status and quality of life in patients surviving 10 years after lung transplantation. Am. J. Transplant. 2005; 5: 1099-1104.
- Trulock E. P., Christie J. D., Edwards L. B. et al. Registry of the International Society for Heart and Lung Transplantation: twenty-fourth official adult lung and heart-lung transplantation report - 2007. J. Heart Lung Transplant. 2007; 26: 782-795.
- Aris R., Neuringer I., Weiner M., Ontjes D. Severe osteoporosis before and after lung transplantation. Chest 1996; 109: 1176- 1183.
- Spira A., Gutierrez C., Chaparro C. et al. Osteoporosis and lung transplantation: a prospective study. Chest 2000; 117: 476- 481.
- Aris R., Lester G., Ontjes D. Treatment of bone disease in cystic fibrosis. Curr. Opin. Pulm. Med. 2004; 10: 524-530.
- Epstein S., Shane E. Transplantation osteoporosis. In: Marcus R., Feldman D., Kelsey J., eds. Osteoporosis. 2-nd ed. New York: Academic Press; 2001. 327-235.
- Trombetti A., Gerbase M. W., Spiliopoulos A. et al. Bone mineral density in lung transplant recipient before and after graft: prevention of lumbar post-transplantation-accelerated bone loss by pamidronate. J. Heart Lung Transplant. 2000; 19: 736-743.
- Shane E., Epstein S. Transplantation osteoporosis. Transplant. Rev. 2001; 15: 11-16.
- Shane E., Silverberg S. J., Donovan D. et al. Osteoporosis in lung transplantation candidates with end stage pulmonary disease. Am. J. Med. 1996; 101: 262-269.
- Tschopp O., Boehler A., Speich R. et al. Osteoporosis before lung transplantation: association with low body mass index, but not with underlying disease. Am. J. Transplant. 2002; 2: 167- 172.
- Ferrari S. L., Nicod L. P., Hamacher J. et al. Osteoporosis in the patients undergoing lung transplantation. Eur. Respir. J. 1996 ; 9: 2378-2382.
- Caplan-Shaw C. E., Arcasoy S. M., Shawe E. et al. Osteoporosis in diffuse parenchymal lung disease. Chest 2006; 129: 140- 146.
- Laet De C., Kanis J. A., Odén A. et al. Body mass index as a predictir of fracture risk: a meta-analysis. Osteoporos. Int. 2005; 16: 1330-1338.
- Krall E. A., Dawson-Hughes B. Walking is related to bone density and rates of bone loss. Am. J. Med. 1994; 96: 20-26.
- Vrieze A., Greef de H. M., Wykstra P. J., Wempe J. B. Low bone mineral density in COPD patients related to worse lung function, low weight and decreased fat-free mass. Osteoporos. Int. 2007; 18: 1197-1202.
- Jorgensen N. R., Schwarz P., Holme I. et al. The prevalence of osteoporosis in patients with chronic obstructive pulmonary disease - a cross-sectional study. Respir. Med. 2006; 4: 34- 38.
- Gregg E. W., Cauley J. A., Seeley D. G. et al. Physical activity and osteoporotic fracture risk in older women. Ann. Intern. Med. 1998; 129: 81-88.