Carbohydrate metabolic disturbances in gout: detection rate and clinical featureS
- Authors: Eliseev M.S.1, Barskova V.G.1, Eliseev MS2, Barskova VG2
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Affiliations:
- Научно-исследовательский институт ревматологии РАМН
- Laboratory of Microcrystalline Arthritides, Research Institute of Rheumatology, Russian Academy of Medical Sciences
- Issue: Vol 82, No 5 (2010)
- Pages: 50-54
- Section: Editorial
- URL: https://journals.rcsi.science/0040-3660/article/view/30600
- ID: 30600
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Full Text
Abstract
Subjects and methods. One hundred and ninety-five patients with gout were examined. Their mean age was 54.8 ± 10.4 years; disease duration was 10 (6-15) years. Anthropometry was estimated; the levels of uric acid (UA), creatinine, and lipid metabolic parameters were measured fasting; the concentrations of glucose were estimated fasting and 2 hours after use of 75 g of glucose; UA excretion and glomerular filtration rate were calculated.
Results. Carbohydrate metabolic disorders were found in 112 (57.4%) patients with gout: type 2 diabetes (T2D) in 67 (34.3%); impaired fasting glycemia in 23 (11.8%); impaired glucose tolerance in 22 (11.3%); the diagnosis of T2D was first detected in 35 patients with gout, in 12 of the 35 (34%) cases after oral glucose tolerance test (OGTT). The detection rate of carbohydrate metabolic disturbances was in direct proportion to serum UA levels. This value was 513.7 ± 122.2 μmol/l in gouty patients with carbohydrate metabolic disturbances and 472.4 ± 121.9 μmol/l in normoglycemic patients (p = 0.026). High body mass index and elevated serum were significantly determined in hyperglycemic patients; coronary heart disease (CHD) and arterial hypertension were more frequently diagnosed.
Conclusion. OGTT causes a 34% increase in the detection rate of T2D in patients with gout. Carbohydrate metabolic disturbances are revealed in the majority of patients with gout and associated with obesity, hypertriglyceridemia, high serum UA levels, chronic disease forms, the high incidence of CHD and arterial hypertension.
About the authors
Maksim Sergeevich Eliseev
Научно-исследовательский институт ревматологии РАМН
Email: elecmax@rambler.ru
лаборатория микрокристаллических артритовканд. мед. наук, ст. науч. сотр. НИИ ревматологии РАМН, тел.: 8-499-614-44-54; Научно-исследовательский институт ревматологии РАМН
Viktoriya Georgievna Barskova
Научно-исследовательский институт ревматологии РАМН
Email: barskova@irramn.ru
лаборатория микрокристаллических артритовд-р мед. наук, лаб. микрокристаллических артритов НИИ ревматологии РАМН; Научно-исследовательский институт ревматологии РАМН
M S Eliseev
Laboratory of Microcrystalline Arthritides, Research Institute of Rheumatology, Russian Academy of Medical SciencesLaboratory of Microcrystalline Arthritides, Research Institute of Rheumatology, Russian Academy of Medical Sciences
V G Barskova
Laboratory of Microcrystalline Arthritides, Research Institute of Rheumatology, Russian Academy of Medical SciencesLaboratory of Microcrystalline Arthritides, Research Institute of Rheumatology, Russian Academy of Medical Sciences
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