The clinical diagnostic value of a study of the activity of enzymes of the guanyl branch of purine metabolism in patients with ankylosing spondyloarthritis
- Authors: Zborovskiy A.B.1, Mozgovaya E.E.1, Martem'yanov V.F.1, Slyusar' O.P.2, Stazharov M.Y.1, Bedina SA1, Zborovsky AB3, Mozgovaya EE3, Martemyanov VF3, Slyusar OP4, Stazharov MY.3, Bedina SA3
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Affiliations:
- ГУ НИИ клинической и экспериментальной ревматологии РАМН
- Городская клиническая больница № 25
- Research Institute of Clinical and Experimental Rheumatology, Russian Academy of Medical Sciences
- City Clinical Hospital Twenty Five
- Issue: Vol 82, No 4 (2010)
- Pages: 48-52
- Section: Editorial
- URL: https://journals.rcsi.science/0040-3660/article/view/30591
- ID: 30591
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Full Text
Abstract
Materials and methods. The serum activities of the PM enzymes: xanthine oxidase (XO), guanine deaminase (GDA), guanosine deaminase (GSDA), purine nucleoside phosphorylase (PNP), guanosine phosphorylase (GP), and adenosine deaminase (ADA) were determined in 55 patients (51 males and 4 females) aged 36.0 ± 1.4 years). A control group comprised 30 apparently age- and gender-matched healthy individuals, as in the study group.
Results. On admission, the patients were found to have increased XO, GDA, PNP, and GD activities and decreased GSDA activity. The higher activity of the process was observed, the greater activities of GDA, XO, PNP, GP and the lower activity of GSDA and ADA were. There were the enzymatic activity differences that depended on the degree of pathological process activity, clinical form, the magnitude of X-ray changes, and the degree of joint functional insufficiency.
Conclusion. The findings suggest that there may be PM disturbances in the immunocompetent cells.
About the authors
Aleksandr Borisovich Zborovskiy
ГУ НИИ клинической и экспериментальной ревматологии РАМН
Email: alena@vistcom.ru
зам. дир. по науч. работе, д-р мед. наук, проф., акад. РАМН, тел.: (8442)35-56-48; ГУ НИИ клинической и экспериментальной ревматологии РАМН
Elena Eduardovna Mozgovaya
ГУ НИИ клинической и экспериментальной ревматологии РАМН
Email: alena@vistcom.ru
клинико-биохимическая лаб., вед. науч. сотр., канд. мед. наук, тел.: (8442)35-56-48; ГУ НИИ клинической и экспериментальной ревматологии РАМН
Vladislav Fedorovich Martem'yanov
ГУ НИИ клинической и экспериментальной ревматологии РАМНклинико-биохимическая лаб., зав., НИИ КиЭР РАМН, д-р мед. наук, проф., тел.: (8442)35-29-05; ГУ НИИ клинической и экспериментальной ревматологии РАМН
Ol'ga Petrovna Slyusar'
Городская клиническая больница № 25
Email: alena@vistcom.ru
ревматологическое отд-ние, зав., канд. мед. наук, тел.: (8442)35-00-05; Городская клиническая больница № 25
Mikhail Yur'evich Stazharov
ГУ НИИ клинической и экспериментальной ревматологии РАМНклинико-биохимическая лаб., вед. науч. сотр., канд. мед. наук, тел.: (8442)35-29-05; ГУ НИИ клинической и экспериментальной ревматологии РАМН
S A Bedina
ГУ НИИ клинической и экспериментальной ревматологии РАМНГУ НИИ клинической и экспериментальной ревматологии РАМН
A B Zborovsky
Research Institute of Clinical and Experimental Rheumatology, Russian Academy of Medical SciencesResearch Institute of Clinical and Experimental Rheumatology, Russian Academy of Medical Sciences
E E Mozgovaya
Research Institute of Clinical and Experimental Rheumatology, Russian Academy of Medical SciencesResearch Institute of Clinical and Experimental Rheumatology, Russian Academy of Medical Sciences
V F Martemyanov
Research Institute of Clinical and Experimental Rheumatology, Russian Academy of Medical SciencesResearch Institute of Clinical and Experimental Rheumatology, Russian Academy of Medical Sciences
O P Slyusar
City Clinical Hospital Twenty FiveCity Clinical Hospital Twenty Five
M Yu Stazharov
Research Institute of Clinical and Experimental Rheumatology, Russian Academy of Medical SciencesResearch Institute of Clinical and Experimental Rheumatology, Russian Academy of Medical Sciences
S A Bedina
Research Institute of Clinical and Experimental Rheumatology, Russian Academy of Medical SciencesResearch Institute of Clinical and Experimental Rheumatology, Russian Academy of Medical Sciences
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