Antithyroid antibodies of varying specificity in the pathogenesis and diagnosis of autoimmune thyroid diseases


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Abstract

Aim. To compare the possible pathogenetic and clinicodiagnostic value of antithyroid autoantibodies (autoAB) different in specificity, such as monospecific ones to thyroglobulin and thyroid peroxidase (anti-TG and anti-TPO autoAB) and bispecific ones to thyroglobulin and thyroid peroxidase simultaneously (anti-TGPO autoAB), in patients with autoimmune thyroid diseases.
Materials and methods. The sera from 240 patients with autoimmune thyroiditis (AIT) and from 124 with diffuse toxic goiter (DTG) were examined. The sera from 40 healthy donors served as a control. The sera were screened for anti-TG and anti-TPO autoAB, anti-TGPO autoAB, by employing enzyme immunoassay and/or radioimmunoassay. The results were statistically processed using the variation statistics-based programs.
Results. The specific features of an autoantigenic component to thyroid tissues were found in the sera of patients with AIT and DTG. An association was established between the progression of disease and the phasic change of autoAB populations or their combinations.
Conclusion. The procedure for evaluating seropositivity for antithyroid autoAB, which is referred to as non-invasive studies, can be considered as a criterion test in the diagnosis and prediction of the course of AIT and DTG.

About the authors

Evgeniya Valer'evna Ivanova

ГКБ № 81

Email: iva0577@mail.ru
отделение эндокринологииврач-эндокринолог; ГКБ № 81

Zemfira Ismailovna Bogatyreva

ГКБ № 81

отделение эндокринологииврач-эндокринолог; ГКБ № 81

Marina Aleksandrovna Isaeva

медицинский центр "МедСтайл-Эффект"

Email: isaeva_marina@bk.ru
отделение эндокринологиизав. отд; медицинский центр "МедСтайл-Эффект"

E N Suchkova

Астраханская государственная медицинская академия (АГМА) им. А. В. Луначарского

клиника эндокринологиик. м. н., доцент кафедры и клиники терапии с курсом эндокринологииглавный эндокринолог Минздрава Астраханской области; Астраханская государственная медицинская академия (АГМА) им. А. В. Луначарского

M A Baysugurov

Астраханская государственная медицинская академия (АГМА) им. А. В. Луначарского

клиника эндокринологиик. м. н., врач-эндокринолог, клиника терапии с курсом эндокринологии; Астраханская государственная медицинская академия (АГМА) им. А. В. Луначарского

Anna Vladimirovna Andreeva

ГКБ № 81

отделение эндокринологииврач-эндокринолог, ординатор кафедрыкафедра эндокринологии и диабетологии; ГКБ № 81

Anastasiya Aleksandrovna Korotkova

ММА им. И. М. Сеченова

Email: fleur@andyone.in
аспирант; ММА им. И. М. Сеченова

A Notkins

Национальный институт челюстно-лицевой хирургии, Национальные институты здоровья

Email: anotkins@mail.nih.gov
лаборатория иммунологиидоктор наук, проф. по курсу иммунологии, зав. отделом экспериментальной медицины и иммунологии; Национальный институт челюстно-лицевой хирургии, Национальные институты здоровья

Mikhail Aleksandrovich Pal'tsev

ММА им. И. М. Сеченова

Email: stepanova@mmascience.ru
акад. РАН и РАМН, д. м. н., проф., зав. кафедрой с курсом общей патологии; ММА им. И. М. Сеченова

Sergey Viktorovich Suchkov

Астраханская государственная медицинская академия (АГМА) им. А. В. Луначарского

Email: ssuchkov@online.ru
клиника эндокринологиид. м. н., проф. по курсу клинической иммунологии кафедры патанатомии с курсом общей патологии; Астраханская государственная медицинская академия (АГМА) им. А. В. Луначарского

E V Ivanova

Z I Bogatyreva

M A Isayeva

E N Suchkova

M A Baisugurov

A V Andreyeva

A A Korotkova

A Notkins

M A Paltsev

S V Suchkov

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