Clinical experience with infliximab administration in patients with rheumatoid arthritis by Russian register data
- Authors: Lukina G.V.1, Sigidin Y.A.1, Nasonov E.L.1, Lukina GV1, Sigidin Y.A1, Nasonov EL1
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Affiliations:
- Учреждение Российской академии медицинских наук Научно-исследовательский институт ревматологии РАМН
- Issue: Vol 81, No 8 (2009)
- Pages: 65-69
- Section: Editorial
- URL: https://journals.rcsi.science/0040-3660/article/view/30508
- ID: 30508
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Full Text
Abstract
Material and methods. The register included 297 patients with a documented diagnosis of RA who had for the first time treated with infliximab. The efficacy of the drug was evaluated by EULAR criteria based on the dynamics of DAS28 index.
Results. The results of infliximab treatment show good response of RA patients to standard courses of infliximab. A good/satisfactory effect by EULAR criteria was achieved in 80% patients to week 22 of therapy and in 85% to week 46. After 6-month (22 week) infliximab treatment a good effect was achieved in 15.7% patients, satisfactory - in 64.7%; 19.6% patients did not respond. Remission (DAS28 < 2.6 units) was achieved in 7% patients. Infliximab tolerance was satisfactory. Non-severe infusion reactions were most frequent unwanted effects. To treatment week 22, ten patients developed serious side effects causing the drug discontinuation.
Conclusion. The results of the Russian register confirm a high therapeutic potential and satisfactory tolerance of infliximab observed in real rheumatological practice of the treatment of severe RA. These results agree with those of European registers of infliximab.
About the authors
Galina Viktorovna Lukina
Учреждение Российской академии медицинских наук Научно-исследовательский институт ревматологии РАМН
Email: gv13@yandex.ru
д. м. н., вед. н. с., лаборатория клинической фармакологии; Учреждение Российской академии медицинских наук Научно-исследовательский институт ревматологии РАМН
Yakov Aleksandrovich Sigidin
Учреждение Российской академии медицинских наук Научно-исследовательский институт ревматологии РАМН
Email: sigidiny@gmail.com
д. м. н., проф., руководитель лаборатории клинической фармакологии; Учреждение Российской академии медицинских наук Научно-исследовательский институт ревматологии РАМН
Evgeniy L'vovich Nasonov
Учреждение Российской академии медицинских наук Научно-исследовательский институт ревматологии РАМН
Email: sokrat@rheumatolog.ru
д. м. н., проф., акад. РАМН, директор; Учреждение Российской академии медицинских наук Научно-исследовательский институт ревматологии РАМН
G V Lukina
Ya A Sigidin
E L Nasonov
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