The role of balanced low-protein diet in inhibition of progression of predialysis chronic disease of the kidneys in systemic diseases
- Authors: Milovanov Y.S.1, Lysenko L.V.1, Milovanova L.Y.1, Dobrosmyslov I.A.1, Milovanov Y.S1, Lysenko LV1, Milovanova LY.1, Dobrosmyslov IA1
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Affiliations:
- Московская медицинская академия им. И. М. Сеченова
- Issue: Vol 81, No 8 (2009)
- Pages: 52-57
- Section: Editorial
- URL: https://journals.rcsi.science/0040-3660/article/view/30499
- ID: 30499
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Full Text
Abstract
Material and methods. Forty six patients with stage III-IV of CDK in systemic diseases (33 SLE patients and 13 with systemic vasculitis) were randomized into three groups. Group 1 consisted of 18 patients with CDK (10 with stage III and 8 with stage IV). They received LPD (0.6 g/kg/day) with addition of essential keto/amino acids for 24-48 months. Group 2 of 18 CDK patients with the same stages received the same diet but greater amount of vegetable protein (highly purified soya protein) to 0.3 g/kg/day in highly energetic nutrient mixture. Group 3 - 10 CDK patients (7 with stage III and 3 with stage IV) received free diet. Group 1 and 2 patients received LPD irrespective of the nutrient status assessed basing on anthropometric and other data. Protein consumption and caloric value were estimated by 3-day food diary.
Results. Before diet therapy, out of 46 examinees nutrient status was abnormal in 45.7% patients. Both variants of LPD were well tolerated and nutrient status was corrected while the rate of nutritive disorders in group 3 increased 1.5-fold (from 40 to 60%) with progression of renal failure. Intake of LPD diet for at least a year reduced glomerular filtration rate inhibition, especially in addition of highly energetic mixture.
Conclusion. Early (predialysis) restriction of diet protein (0.6 g/kg/day) with addition of highly energetic mixture and essential keto/amino acids improves a nutritive status of CDK patients and inhibits GFR decline.
About the authors
Yuriy Sergeevich Milovanov
Московская медицинская академия им. И. М. Сеченова
Email: yuriymilovanov@mail.ru
д. м. н., доцент, кафедра нефрологии и гемодиализа факультета послевузовского профессионального образования врачей ММА им. И. М. Сеченова; Московская медицинская академия им. И. М. Сеченова
Lidiya Vladimirovna Lysenko
Московская медицинская академия им. И. М. Сеченовад. м. н., проф., кафедра терапии медико-профилактического факультета ММА им. И. М. Сеченова; Московская медицинская академия им. И. М. Сеченова
Lyudmila Yur'evna Milovanova
Московская медицинская академия им. И. М. Сеченовак. м. н., н. с., отдел нефрологии научно-исследовательского центра; Московская медицинская академия им. И. М. Сеченова
Igor' Aleksandrovich Dobrosmyslov
Московская медицинская академия им. И. М. Сеченовазав. отделением "искусственная почка" клиники нефрологии, внутренних и профессиональных болезней; Московская медицинская академия им. И. М. Сеченова
Yu S Milovanov
L V Lysenko
L Yu Milovanova
I A Dobrosmyslov
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