Correlations between the levels of vitamin D, parathormone, calcium, blood phosphates in patients with chronic disease of the kidneys untreated with replacement renal therapy
- Authors: Smirnov A.V.1, Volkov M.M.1, Galkina O.V.1, Zhloba A.A.1, Emanuel' V.L.1, Smirnov AV1, Volkov MM1, Galkina OV1, Zhloba AA1, Emanel VL1
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Affiliations:
- НИЦ Санкт-Петербургского государственного медицинского университета им. акад. И. П. Павлова
- Issue: Vol 81, No 8 (2009)
- Pages: 49-52
- Section: Editorial
- URL: https://journals.rcsi.science/0040-3660/article/view/30496
- ID: 30496
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Full Text
Abstract
Material and methods. Serum levels of creatinine, electrolytes, parathormone (PTH), 25(OH)-vitamin D (calcidiol -CD), 1,25 (OH)2-vitamin D (calcitriol -CT), calcium (Ca) and phosphates (P) excretion with urine were studied in 465 patients aged 52.2 ± 15.5 years with CDK stage I-V given no TRRF having mean glomerular filtration rate (GFR) 51.8 ± 27.1 ml/min.
Results. A CT level lowered with CDK progression and directly correlated with GFR, blood levels of Ca and CD. Correlation with PTH was not found. CD did not correlate with GFR. PTH rose from stage II CDK and its concentration in the blood correlated negatively with GFR, blood Ca (in lesser degree), directly correlated with P. Ca lowered at stage V of CDK, P - at stage II, increased at stage IV. In reduction of GFR 24-h excretions of P and Ca diminished in spite of growth of their excreted fractions and were related directly with CT.
Conclusion. A rise of PTH and fall of CT occur at early CDK stages. P disbolism seems to play a key role in genesis of hyperparathyrosis. We are the first to show lowering of 24-hour Ca and P excretioin with CDK progression which may be caused by a progressive CT deficiency.
About the authors
Aleksey Vladimirovich Smirnov
НИЦ Санкт-Петербургского государственного медицинского университета им. акад. И. П. Павлова
Email: smirnov@nephrolog.ru
д. м. н., проф., кафедра пропедевтики внутренних болезней СПбГМУ, директор НИИ нефрологии СПбГМУ; НИЦ Санкт-Петербургского государственного медицинского университета им. акад. И. П. Павлова
Mikhail Mikhaylovich Volkov
НИЦ Санкт-Петербургского государственного медицинского университета им. акад. И. П. Павлова
Email: vmm58@mail.ru
к. м. н., ассистент кафедры, кафедра пропедевтики внутренних болезней СПбГМУ; НИЦ Санкт-Петербургского государственного медицинского университета им. акад. И. П. Павлова
Ol'ga Vladimirovna Galkina
НИЦ Санкт-Петербургского государственного медицинского университета им. акад. И. П. Павлова
Email: ovgalkina@mail.ru
к. м. н., доцент кафедры, кафедра клинической лабораторной диагностики с курсом молекулярной медицины СПбГМУ; НИЦ Санкт-Петербургского государственного медицинского университета им. акад. И. П. Павлова
Aleksandr Anatol'evich Zhloba
НИЦ Санкт-Петербургского государственного медицинского университета им. акад. И. П. Павлова
Email: zhloba@mail.spbnit.ru
д. м. н., проф., руководитель отдела, отдел биохимии НИЦ СПбГМУ; НИЦ Санкт-Петербургского государственного медицинского университета им. акад. И. П. Павлова
Vladimir Leonidovich Emanuel'
НИЦ Санкт-Петербургского государственного медицинского университета им. акад. И. П. Павлова
Email: vladimirem@gmail.com
д. м. н., проф., зав. кафедрой, кафедра клинической лабораторной диагностики с курсом молекулярной медицины СПбГМУ; НИЦ Санкт-Петербургского государственного медицинского университета им. акад. И. П. Павлова
A V Smirnov
M M Volkov
O V Galkina
A A Zhloba
V L Emanel
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