Risk of cardiovascular complications in patients with frequent hypertensive crises


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Abstract

Aim. To investigate a relative risk of cardiovascular complications in uncomplicated hypertensive crises (UHC) in hypertensive patients.
Material and methods. A questionnaire retrospective case-control study covered one-third of patients registered in the data base of a hospital or outpatient clinic. The patients were matched by basic characteristics. By frequency of UHC the patients were divided into two groups. Group 1 (n = 305) comprised patients with frequent (weekly or more often) UHC, group 2 (n = 558) consisted of patients with rare UHC (monthly or less frequent).
Results. Patients of group 1 had a longer history of arterial hypertension (13 ± 9 years vs 9 ± 7.8 years, p < 0.05). The target blood pressure was achieved in group 1 in 42% vs 56% in group 2; p < 0.05). Group 1 patients had a higher risk of non-fatal stroke/transient ischemic attack (TIA) - 18 and 10% (OR 1.94, 95% CI 1.28-2.93; p < 0.05), chronic cardiac failure (44 vs 30%; OR 1.64; 95% CI 1.22-2.21; p < 0.05), left ventricular hypertrophy (72 and 56%; OR 2.11; 95% CI 1.52-2.93; p < 0.05) and myocardial ischemia (56 and 38%; OR 2.05; 95%CI 1.53-2.74; p < 0.05). UHC frequency had no significant influence on the risk of non-fatal myocardial infarction (19 vs 15%; OR 1.34; 95% CI 0.92-1.94; p > 0.05).
Conclusion. Frequent UHC raise the risk of non-fatal acute disorder of cerebral circulation, chronic cardiac failure, ischemia and left ventricular hypertrophy. Frequency of UHC is not related to the risk of myocardial infarction.

About the authors

Igor' Petrovich Kolos

ФГУ Российский кардиологический научно-производственный комплекс Росмедтехнологий

Email: docsn173@yandex.ru
к.м.н., н.с., отд. возрастных проблем сердечно-сосудистых заболеваний ИИК им. А. Л. Мясникова; ФГУ Российский кардиологический научно-производственный комплекс Росмедтехнологий

Irina Evgen'evna Chazova

ФГУ Российский кардиологический научно-производственный комплекс Росмедтехнологий

Email: chazova@hotmail.com
д.м.н., проф., руководитель отдела, отд. системных гипертензий ИИК им. А. Л. Мясникова; ФГУ Российский кардиологический научно-производственный комплекс Росмедтехнологий

Sergey Nikolaevich Tereshchenko

ФГУ Российский кардиологический научно-производственный комплекс Росмедтехнологий

Email: stereschenko@yandex.ru
д.м.н., проф., руководитель отдела, отд. сердечной недостаточности и заболеваний миокарда ИКК им. А. Л. Мясникова; ФГУ Российский кардиологический научно-производственный комплекс Росмедтехнологий

Sergey Nikolaevich Nakonechnikov

ФГУ Российский кардиологический научно-производственный комплекс Росмедтехнологий

Email: snn_cardio@mail.ru
к.м.н., ученый секретарь РКНПК, руководитель отдела, отд. новых мед. информационных технологий РКНПК; ФГУ Российский кардиологический научно-производственный комплекс Росмедтехнологий

I P Kolos

I E Chazova

S N Tereschenko

S N Nakonechnikov

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