Email this article Clinical and epidemiological features of Berkitt's lymphoma
- Authors: Baryakh E.A.1, Kravchenko S.K.1, Kremenetskaya A.M.1, Zvonkov E.E.1, Obukhova T.N.1, Magomedova A.U.1, Vorob'ev A.I.1, Baryakh EA1, Kravchenko SK1, Kremenetskaya AM1, Zvonkov EE1, Obukhova TN1, Magomedova KU1, Vorobyev AI1
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Affiliations:
- ГУ Гематологический научный центр РАМН
- Issue: Vol 81, No 7 (2009)
- Pages: 47-53
- Section: Editorial
- URL: https://journals.rcsi.science/0040-3660/article/view/30387
- ID: 30387
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Abstract
Material and methods. The trial enrolled 72 patients (51 males and 21 females, age 14-69, mean age 27 years) treated in 1995-2008.
Results. Stage I BL (by S.B. Murphy) was diagnosed in 5 patients, stage II - in 9, stage III - in 25, IV - in 14 patients, B-cell acute lymphoblastic leukemia (ALL) (L3) - in 19 patients. Intoxication was seen in 56(78%) patients, 38% patients had severe cachexia. Elevated concentration of lactatedehydrogenase (LDG) was detected in 57(79%) patients. In all the cases clinical symptoms developed for 1-3 months, median 6 weeks. Bone marrow involvement was diagnosed in 22 (31%) patients, CNS was affected in 17(24%) patients, of them 14 were males. Fifty two (72%) patients had abdominal, retroperitoneal and/or small pelvis tumors. Intestinal, hepatic, renal and gastric tumors occurred most frequently. Specific ascitis was detected in 25(48%), tumor pleuritis - in 11(15%) patients. BL of the facial skeleton, Waldeyer's ring, oro- and nasopharynx was in 12(17%) patients. Seven patients had concomitant involvement of the CNS. Eight (38%) and 2(10%) women had tumors of the ovaries and uterus, respectively.
Conclusion. BL is characterized by the following clinical features: young age of the patients, most of them are males, B-symptoms, short history, generalized stages, extranodal lesions, frequent involvement of the bone marrow and CNS.
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About the authors
Elena Aleksandrovna Baryakh
ГУ Гематологический научный центр РАМН
Email: baryakh@mail.ru
Отделение химиотерапии гематологических заболеваний и интенсивной терапиин. с., к. м. н; ГУ Гематологический научный центр РАМН
Sergey Kirillovich Kravchenko
ГУ Гематологический научный центр РАМН
Email: krav@blood.ru
Отделение химиотерапии гематологических заболеваний и интенсивной терапиинаучный руководитель отд., доцент; ГУ Гематологический научный центр РАМН
Aleksandra Mikhaylovna Kremenetskaya
ГУ Гематологический научный центр РАМН
Email: mtkalexandra@gmail.com
Отделение химиотерапии гематологических заболеваний и интенсивной терапиизав. отделением; ГУ Гематологический научный центр РАМН
Evgeniy Evgen'evich Zvonkov
ГУ Гематологический научный центр РАМН
Email: zvonkov@blood.ru
Отделение химиотерапии гематологических заболеваний и интенсивной терапиик.м.н; ГУ Гематологический научный центр РАМН
Tat'yana Nikiforovna Obukhova
ГУ Гематологический научный центр РАМН
Email: obukhova@blood.ru
Отделение химиотерапии гематологических заболеваний и интенсивной терапиикариологическая лаборатория, с.н.с., к.м.н; ГУ Гематологический научный центр РАМН
Aminat Umaraskhabovna Magomedova
ГУ Гематологический научный центр РАМН
Email: maminat@mail.ru
Отделение химиотерапии гематологических заболеваний и интенсивной терапиис.н.с., д.м.н; ГУ Гематологический научный центр РАМН
Andrey Ivanovich Vorob'ev
ГУ Гематологический научный центр РАМНОтделение химиотерапии гематологических заболеваний и интенсивной терапиидиректор, акад. РАМН и РАН; ГУ Гематологический научный центр РАМН
E A Baryakh
S K Kravchenko
A M Kremenetskaya
E E Zvonkov
T N Obukhova
K U Magomedova
A I Vorobyev
References
- Барях Е. А. Лимфома Беркитта и беркиттоподобные лимфомы. В кн.: Воробьев А. И., Кременецкая А. М. (ред.). Атлас "Опухоли лимфатической системы". М.: Ньюдиамед, 2007. 154-167.
- De-The G. Epidemiologie of Burkitt's lymphoma: evidance for a casual association with EBV. Epidemiol. Rev. 1979; 36: 692-698.
- Oguonu T., Emodi E., Kaine W. Epidimiologie of Burkitt's lymphoma in Enugu, Nigeria. Ann. Trop. Paediatr. 2002; 22: 369-374.
- Ziegler J. L. Burkitt's lymphoma. N. Engl. J. Med. 1981; 305: 735-745.
- Аль-Мадхажжи А. А. Клинические и сероэпидемиологические особенности лимфомы Беркитта в Республике Йемен: Автореф. дис. ... канд. мед. наук. М.; 1998.
- Blum K. A., Lozansky G., Byrd J. Adult Burkitt's leukemia and lymphoma. Blood 2004; 104(10): 3009-3020.
- Shad A., Magrath I. Non Hodgkin's lymphoma. Pediatr. Clin. Am. 1997; 44: 863-890.
- Levine A. M. Acquired immunodeficiency syndrome-related lymphoma. Blood 1992; 80: 8-20.
- Spina M., Tirelli U., Zagonel V. et al. Burkitt's lymphoma in adult with and without immunodeficiency virus infection. A single-institution clinicopathologic study of 75 patients. Cancer 1998; 82(4): 766-774.
- Барях Е. А. Диагностика и лечение лимфомы Беркитта: Автореф. дис. ... канд. мед. наук. М.; 2007.
- Lazzi S., Ferrari F., Nyong'o A. et al. HIV-associated malignant lymphomas in Kenya (equatorial Africa). Hum. Pathol. 1998; 29: 1285-1289.
- Hoelther D., Ludwid W. D., Thiel E. et al. Improved outcome in adult B-cell acute lymphoblastic leukemia. Blood 1996; 87: 495-508.
- Thomas D., Cortes J., O'Brien S. et al. Hyper-CVAD program in Burkitt's type adult acute lymphoblastic leukemia. J. Clin. Oncol. 1999; 17: 2461-2470.
- Sariban E., Edwards S., Janus C., Magrath I. Central nervous system involvement in American Burkitt's lymphoma. J. Clin. Oncol. 1983; 1: 677-680.
- McWilliams N., Hatfield W., Jackson R. Epidemiological notes and reports on Burkitt's lymphoma - Winchester, Virginia. Morbid. Mortal. Wkly Rep. 1997; 46: 4674-4678.
- Ardekian L., Rachmiel A., Rosen D. et al. Burkitt's lymphoma of the oral cavity in Israel. J. Craniomaxillofac. Surg. 1999; 27(5): 294-297.
- Bauer G. P., Volk M. S., Siddiqui S. Y. Burkitt's lymphoma of the parafaringeal space. Arch. Otolaryngol. Head Neck Surg. 1993; 119(1): 117-120.
