Trisomy of chromosome 8 in Ph-negative cells of the bone marrow in patients with chronic myeloid leukemia treated with inhibitors of BCR-ABL tyrosinkinases

Anna Grigor'evna Turkina; Туркина Анна Григорьевна; Elena Vasil'evna Domracheva; Домрачева Елена Васильевна; Aleksandra Valer'evna Vorontsova; Воронцова Александра Валерьевна; Elena Aleksandrovna Aseeva; Асеева Елена Александровна; Ol'ga Yur'evna Vinogradova; Виноградова Ольга Юрьевна; Ol'ga Veniaminovna Stakhina; Стахина Ольга Вениаминовна; Galina Anatol'evna Gusarova; Гусарова Галина Анатольевна; Ol'ga Arkad'evna Dyagileva; Дягилева Ольга Аркадьевна; Elena Aleksandrovna Semenova; Семенова Елена Александровна; Marina Vasil'evna Vakhrusheva; Вахрушева Марина Васильевна; Tamara Ivanovna Kolosheynova; Колошейнова Тамара Ивановна; Evgeniy Mikhaylovich Abakumov; Абакумов Евгений Михайлович; Ekaterina Yur'evna Chelysheva; Челышева Екатерина Юрьевна; Svetlana Rudol'fovna Goryacheva; Горячева Светлана Рудольфовна; Tat'yana Vladimirovna Ivanova; Иванова Татьяна Владимировна; Elena Stanislavovna Zakharova; Захарова Елена Станиславовна; Lyubov' Yur'evna Kolosova; Колосова Любовь Юрьевна; Adel' Vladimirovna Zakharova; Захарова Адель Владимировна; Irina Nikolaevna Naumova; Наумова Ирина Николаевна; Larisa Vladimirovna Dyachenko; Дяченко Лариса Владимировна; Sergey Mikhaylovich Kulikov; Куликов Сергей Михайлович; Lidiya Grigor'evna Kovaleva; Ковалева Лидия Григорьевна; Nina Dmitrievna Khoroshko; Хорошко Нина Дмитриевна; A G Turkina; Turkina A G; E V Domracheva; Domracheva E V; A V Vorontsova; Vorontsova A V; E A Aseeva; Aseeva E A; O Yu Vinogradova; Vinogradova O Yu; O V Stakhina; Stakhina O V; G A Gusarova; Gusarova G A; O A Dyagileva; Dyagileva O A; E A Semenova; Semenova E A; M V Vakhrusheva; Vakhrusheva M V; T I Kolosheinova; Kolosheinova T I; E M Abakumov; Abakumov E M; E Yu Chelysheva; Chelysheva E Yu; S R Goryacheva; Goryacheva S R; T V Ivanova; Ivanova T V; E S Zakharova; Zakharova E S; L Yu Kolosova; Kolosova L Yu; A V Zakharova; Zakharova A V; I N Naumova; Naumova I N; L V Dyachenko; Dyachenko L V; S M Kulikov; Kulikov S M; L G Kovaleva; Kovaleva L G; N D Khoroshko; Khoroshko N D

Trisomy of chromosome 8 in Ph-negative cells of the bone marrow in patients with chronic myeloid leukemia treated with inhibitors of BCR-ABL tyrosinkinases

作者: Turkina A.G.¹, Domracheva E.V.¹, Vorontsova A.V.¹, Aseeva E.A.¹, Vinogradova O.Y.¹, Stakhina O.V.¹, Gusarova G.A.¹, Dyagileva O.A.¹, Semenova E.A.¹, Vakhrusheva M.V.¹, Kolosheynova T.I.¹, Abakumov E.M.¹, Chelysheva E.Y.¹, Goryacheva S.R.¹, Ivanova T.V.¹, Zakharova E.S.¹, Kolosova L.Y.¹, Zakharova A.V.¹, Naumova I.N.¹, Dyachenko L.V.¹, Kulikov S.M.¹, Kovaleva L.G.¹, Khoroshko N.D.¹, Turkina AG¹, Domracheva EV¹, Vorontsova AV¹, Aseeva EA¹, Vinogradova OY.¹, Stakhina OV¹, Gusarova GA¹, Dyagileva OA¹, Semenova EA¹, Vakhrusheva MV¹, Kolosheinova TI¹, Abakumov EM¹, Chelysheva EY.¹, Goryacheva SR¹, Ivanova TV¹, Zakharova ES¹, Kolosova LY.¹, Zakharova AV¹, Naumova IN¹, Dyachenko LV¹, Kulikov SM¹, Kovaleva LG¹, Khoroshko ND¹
隶属关系:
1. ГУ Гематологический научный центр РАМН
期: 卷 81, 编号 7 (2009)
页面: 29-36
栏目: Editorial
URL: https://journals.rcsi.science/0040-3660/article/view/30364
ID: 30364

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Aim. To analyse clinical implications of chromosome 8 trisomy in Ph-negative cells of the bone marrow in patients with chronic myeloid leukemia (CML) treated with inhibitors of tyrosinkinases (ITK).
Material and methods. A total of 386 patients with CML (chronic phase - 288, acceleration phase - 77) received imatinib (400-800 mg/day). Because of resistance and/or intolerance some patients were switched to ITK II (nilotinib, dasatinib, bozutinib). This study included 8 CML patients (7 in a chronic phase, 1 in acceleration phase) treated with BCR-ABL ITK inhibitors of the first (imatinib) and the second line (ITK-II). The standard cytogenetic examination, on demand - investigation of the interphase nuclei with FISH, in some cases morphological, cytochemical and histological examinations of the bone marrow were made.
Results. The existence of a Ph-negative clone with trisomy of chromosome 8 had no negative effect on the course of the disease. The patients showed a stable hematological and cytogenetic response and no need in changing treatment policy. In long-term follow-up Ph-negative clone with trisomy of the chromosome 8 persisted without a clear trend to rise in most patients.
Conclusion. Detection of a Ph-negative clone with chromosome 8 trisomy at early stages suggests parallel existence of Ph-positive and Ph-negative clones. None of the patients had myelodisplasia.

关键词

chronic myeloid leukemia, chromosome 8 trisomy, Ph-negative cells, inhibitors of BCR-ABL tyrosinkinase

参考

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Trisomy of chromosome 8 in Ph-negative cells of the bone marrow in patients with chronic myeloid leukemia treated with inhibitors of BCR-ABL tyrosinkinases

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