Results of the treatment of adult acute lymphoblastic leukemia according to ALL-2005 protocol as a basis for new trials

Elena Nikolaevna Parovichnikova; Паровичникова Елена Николаевна; Yuliya Rubenovna Davidyan; Давидян Юлия Рубеновна; Valentin Grigor'evich Isaev; Исаев Валентин Григорьевич; Andrey Nikolaevich Sokolov; Соколов Андрей Николаевич; Galina Aleksandrovna Klyasova; Клясова Галина Александровна; Larisa Pavlovna Mendeleeva; Менделеева Лариса Павловна; Lidiya Semenovna Lyubimova; Любимова Лидия Семеновна; Elena Nikolaevna Ustinova; Устинова Елена Николаевна; Elena Olegovna Gribanova; Грибанова Елена Олеговна; Elena Sergeevna Mavrina; Маврина Елена Сергеевна; Sergey Mikhaylovich Kulikov; Куликов Сергей Михайлович; Kamil' Daniyalovich Kaplanov; Капланов Камиль Даниялович; Tamara Pavlovna Zagoskina; Загоскина Тамара Павловна; Ekaterina Il'inichna Sviridova; Свиридова Екатерина Ильинична; Lyubov' Vladimirovna Gavrilova; Гаврилова Любовь Владимировна; Valeriy Grigor'evich Savchenko; Савченко Валерий Григорьевич; E N Parovichnikova; Parovichnikova E N; Yu R Davidyan; Davidyan Yu R; V G Isaev; Isaev V G; A N Sokolov; Sokolov A N; G A Klyasova; Klyasova G A; L P Mendeleeva; Mendeleeva L P; L S Lyubimova; Lyubimova L S; E N Ustinova; Ustinova E N; E O Gribanova; Gribanova E O; E S Mavrina; Mavrina E S; S M Kulikov; Kulikov S M; K D Kaplanov; Kaplanov K D; T P Zagoskina; Zagoskina T P; E I Sviridova; Sviridova E I; L V Gavrilova; Gavrilova L V; V G Savchenko; Savchenko V G

Results of the treatment of adult acute lymphoblastic leukemia according to ALL-2005 protocol as a basis for new trials

作者: Parovichnikova E.N.¹, Davidyan Y.R.¹, Isaev V.G.¹, Sokolov A.N.¹, Klyasova G.A.¹, Mendeleeva L.P.¹, Lyubimova L.S.¹, Ustinova E.N.¹, Gribanova E.O.¹, Mavrina E.S.¹, Kulikov S.M.¹, Kaplanov K.D.², Zagoskina T.P.³, Sviridova E.I.⁴, Gavrilova L.V.⁵, Savchenko V.G.¹, Parovichnikova EN¹, Davidyan Y.R¹, Isaev VG¹, Sokolov AN¹, Klyasova GA¹, Mendeleeva LP¹, Lyubimova LS¹, Ustinova EN¹, Gribanova EO¹, Mavrina ES¹, Kulikov SM¹, Kaplanov KD¹, Zagoskina TP¹, Sviridova EI¹, Gavrilova LV¹, Savchenko VG¹
隶属关系:
1. ГУ Гематологический научный центр РАМН
2. Волгоградский областной онкологический диспансер
3. Кировский НИИ гематологии и переливания крови
4. Тамбовская областная клиническая больница
5. Саранская городская клиническая больница № 4
期: 卷 81, 编号 7 (2009)
页面: 8-15
栏目: Editorial
URL: https://journals.rcsi.science/0040-3660/article/view/30343
ID: 30343

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Aim. To analyse the results of the treatment according to ALL-2005 protocol for adult patients with acute lymphoblastic leukemia (ALL); on the basis of the summarized evidence on ALL treatment to propose principles for development of a new program of ALL treatment in 15-55-year-old patients.
Material and methods. Five hematological centers (in Moscow, Saransk, Volgograd, Tambov, Kirov) participated in ALL-2005 protocol trial initiated in 2005. A total of 71 adult patients with ALL (age median 27 years) were treated. The results of the MB-2002 study with participation of 16 patients aged 16-23 years performed in the State Hematological Research Center (SHRC) were reviewed.
Results. The results of the induction therapy according to ALL-2005 protocol conducted in Moscow SHRC were good: a complete remission was achieved in 90% patients, early lethality was 6%, resistance was observed in 4%. In regional centers lethality in remission was higher, 5-year overall survival was 28% (in SHRC it was 56%), recurrence-free survival in regional center was 22% versus 51%, respectively. Long-term response by ALL-2005 and MB-2002 in patients aged 19-23 was the same, but toxicity of ALL-2005 treatment was higher (no lethality and 5, 4% in induction and remission, respectively).
Conclusion. The decision was made on design of a new protocol of treatment of Ph-negative ALL for patients aged from 15 to 55 years the main principles of which are the following: continuous treatment with modification of cytostatic drugs doses depending on myelosuppression severity; assessment of tumor cells sensitivity to prednisolone and its replacement for dexametasone throughout the treatment; prolongation of L-asparaginase treatment with elevation of its total dose; monitoring of minimal residual disease (MRD) for decision on late intensification in patients with MRD at late treatment stages (5 months).

关键词

acute lymphoblastic leukemia, therapy, ALL-2005 protocol, MB-2002 protocol, minimal residual disease, prednisolone, dexametasone, L-asparaginase

参考

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Results of the treatment of adult acute lymphoblastic leukemia according to ALL-2005 protocol as a basis for new trials

全文:

详细

关键词

作者简介

Elena Parovichnikova

Yuliya Davidyan

Valentin Isaev

Andrey Sokolov

Galina Klyasova

Larisa Mendeleeva

Lidiya Lyubimova

Elena Ustinova

Elena Gribanova

Elena Mavrina

Sergey Kulikov

Kamil' Kaplanov

Tamara Zagoskina

Ekaterina Sviridova

Lyubov' Gavrilova

Valeriy Savchenko

E Parovichnikova

Yu Davidyan

V Isaev

A Sokolov

G Klyasova

L Mendeleeva

L Lyubimova

E Ustinova

E Gribanova

E Mavrina

S Kulikov

K Kaplanov

T Zagoskina

E Sviridova

L Gavrilova

V Savchenko

参考

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