电邮这篇文章 Norovirus infection in general hospitals for adults
- 作者: Sagalova OI, Bryzgalova IV, Podkolzin AT, Maleev VV, Sagalova OI, Bryzgalova IV, Podkolzin AT, Maleev VV
- 期: 卷 81, 编号 4 (2009)
- 页面: 60-63
- 栏目: Editorial
- URL: https://journals.rcsi.science/0040-3660/article/view/30322
- ID: 30322
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Aim. To determine the role of noroviruses in the rise of hospital outbreaks of acute intestinal infections (AII), to study clinical and epidemiological aspects of hospital noroviral infection.
Material and methods. Routine diagnostic methods and diagnostic tests on the base of polymerase chain reaction (PCR) were used for identification of group A rotaviruses, noroviruses, astroviruses, adenoviruses, salmonella, thermophilic campilobacteria, shigella, enteroinvasive echerichia (EIEC) in 70 adult patients with AII transferred from general hospital to infection hospital in 2003-2007. A part of the strains was typed with primers specific for genetic cluster G2/4.
Results. Routine methods failed to identify causes of hospital infection. PCR detected AII etiology in 77.8% patients. Norovirus of the second genotype (G2) was identified as monoinfection in 87.8% verified cases, in association with other agents - in 12.2%. Typed noroviruses belonged to cluster G2/4. Nosocomial norovirus infection was characterized by winter-spring occurrence and a moderate course.
Conclusion. An essential role of noroviruses in hospital AII outbreaks in elderly patients in winter-spring is shown.
Material and methods. Routine diagnostic methods and diagnostic tests on the base of polymerase chain reaction (PCR) were used for identification of group A rotaviruses, noroviruses, astroviruses, adenoviruses, salmonella, thermophilic campilobacteria, shigella, enteroinvasive echerichia (EIEC) in 70 adult patients with AII transferred from general hospital to infection hospital in 2003-2007. A part of the strains was typed with primers specific for genetic cluster G2/4.
Results. Routine methods failed to identify causes of hospital infection. PCR detected AII etiology in 77.8% patients. Norovirus of the second genotype (G2) was identified as monoinfection in 87.8% verified cases, in association with other agents - in 12.2%. Typed noroviruses belonged to cluster G2/4. Nosocomial norovirus infection was characterized by winter-spring occurrence and a moderate course.
Conclusion. An essential role of noroviruses in hospital AII outbreaks in elderly patients in winter-spring is shown.
参考
- Aitken C., Jeffries D. J. Nosocomial spread of viral disease. Clin. Microbiol. Rev. 2001; 14 (3): 528-546.
- Hansen S., Stamm-Balderjahn S., Zuschneid I. et al. Closure of medical departments during nosocomial outbreaks: data from a systematic analysis of the literature. J. Hosp. Infect. 2007; 65 (4): 348-353.
- Lopman B., Readier M., Vipond I. et al. Clinical manifestation of norovirus gastroenteritis in health care settings. Clin. Infect. Dis. 2004; 39: 318-324.
- Gallimore C., Taylor C., Gennery A. R. et al. Environmental monitoring for gastroenteric viruses in a pediatric primary immunodeficiency unit. J. Clin. Microbiol. 2006; 44 (2): 395-399.
- Мухина А. А., Шипулин Г. А., Подколзин А. Т., Малеев В. В. Калицивирусная инфекция. Инфекц. бол. 2004; 2: 64-73.
- Leuenbergera S., Widdowsonb M., Feilchenfeldta J. et al. Norovirus outbreak in a district general hospital - new strain identified. Swiss. Med. Wkly 2007; 137: 57-61.
- Glass R. I., Noel J., Ando T. et al. The epidemiology of enteric caliciviruses from humans: a reassessment using new diagnostics. J. Infect. Dis. 2000; 181 (suppl. 2): 254-261.
- Goller J. L., Dimitriadis A., Tan A. et al. Long-term features of norovirus gastroenteritis in the elderly. J. Hosp. Infect. 2004; 58 (4): 286-291.
- Mattner F., Sohr D., Heim A. et al. Risk groups for clinical complications of norovirus infections: an outbreak investigation. Clin. Microbiol. Infect. 2006; 12 (1): 69-74.
- Tu E. T., Bull R. A., Kim M.-J. et al. Norovirus excretion in an aged-care setting. J. Clin. Microbiol. 2008; 46 (6): 2119-2121.
- Письмо Роспотребнадзора РФ № 0100/10455-06-32 от 29.09.2006 "О заболеваемости внутрибольничными инфекциями в Российской Федерации в 2005 г. и совершенствовании эпидемиологического надзора за ВБИ". М., 2006.
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