Phenotypes of patients with chronic obstructive pulmonary disease
- Authors: Aver'yanov AV, Chuchalin AG, Polivanova AE, Polivanov GE, Chernyak AV, Neklyudova GV, Naumenko Z.K, Averianov AV, Chuchalin AG, Polivanova AE, Polivanov GE, Chernyak AV, Neklyudova GV, Naumenko Z.K
- Issue: Vol 81, No 3 (2009)
- Pages: 9-14
- Section: Editorial
- URL: https://journals.rcsi.science/0040-3660/article/view/30272
- ID: 30272
Cite item
Full Text
Abstract
Material and methods. Basing on the results of high performance computed tomography, 64 COPD patients aged 46-75 years (FEV1 51 ± 24%) were divided into two groups: 53 patients with emphysematous phenotype (group 1) and 11 patients with bronchytic phenotype (group 2). The groups were compared by constitutional, clinical, functional and roentgenological parameters.
Results. Group 1 patients had significantly less body mass index, more severe edema by Borg's scale, low FEV1, FEV1/FLC, diffuse lung capacity and lung tissue density compared to group 2. Bronchoectases occurred more frequently in group 1 (33 and 9%, respectively).
Conclusion. Heterogenous COPD phenotypes differ not only at the stage of chronic respiratory insufficiency but also at all stages of the disease.
About the authors
A V Aver'yanov
A G Chuchalin
A E Polivanova
G E Polivanov
A V Chernyak
G V Neklyudova
Zh K Naumenko
A V Averianov
A G Chuchalin
A E Polivanova
G E Polivanov
A V Chernyak
G V Neklyudova
Zh K Naumenko
References
- Глобальная стратегия диагностики, лечения и профилактики хронической обструктивной болезни легких. Пересмотр 2006 г.: Пер. с англ. М.: Атмосфера, 2007.
- Boschetto P., Miniati M., Miotto D. Predominant emphysema phenotype in chronic obstructive pulmonary disease patients. Eur. Respir. J. 2003; 21: 450-454.
- Hersh C. P., Washko G. R., Jacobson F. L. et al. Interobserver variability in the determination of upper lobe-predominant emphysema. Chest. 2007; 131(2): 424-431.
- Нечаев В. И. Эмфизема легких: системные проявления болезни. Пульмонология 1999; 1: 54-58.
- Spiegelman D., Israel R. G., Bouchard C., Willett W. C. Absolute fat mass, percent body fat, and body-fat distribution: which is the real determinant of blood pressure and serum glucose? Am. J. Clin. Nutr. 1992; 55: 1033-1044.
- Suganami E., Takagi H., Ohashi H. et al. Leptin stimulates ischemia-induced retinal neovascularization: possible role of vascular endothelial growth factor expressed in retinal endothelial cells. Diabetes 2004; 53: 2443-2448.
- Bruno A., Chanez P., Chiappara G. et al. Does leptin play a cytokine-like role within the airways of COPD patients? Eur. Respir. J. 2005; 26(3): 398-405.
- Cao Y. Angiogenesis modulates adipogenesis and obesity. J. Clin. Invest. 2007; 117: 2362-2368.
- Voros G. Modulation of angiogenesis during adipose tissue development in murine models of obesity. Endocrinology 2005; 146: 4545-4554.
- Gosselink R., Troosters T., Decramer M. Distribution of muscle weakness in patients with stable chronic obstructive pulmonary disease. J. Cardiopulm. Rehabil. 2000; 20: 353-360.
- Celli B. R., Cote C. C., Marin J. M. et al. The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease. N. Engl. J. Med. 2004; 350: 1005-1012.
- Mattson J., Martin J. Emphysema-induced reductions in locomotory skeletal muscle contractile function. Exp. Physiol. 2007; 90(4): 519-525.
- Bellamy D., Hutchison D. C. The effects of salbutamol aerosol on lung function in patients with pulmonary emphysema. Br. J. Dis. Chest 1981: 75(2): 190-196.
- Малова М. Н. Эмфизема легких. М.: Медицина; 1975.
- Соколов Е. И., Маев И. В., Бусарова Г. А. Эмфизема легких. М., 2000.
- Gelb A. E., Hogg J. C., Miller N. L. et al. Contribution of emphysema and small airways in COPD. Chest 1996; 109: 353-359.
- Baldi S., Miniati M., Bellina C. R. et al. Relationship between extent of pulmonary emphysema by high-resolution computed tomography and lung elastic recoil in patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2001; 164: 585-589.
- Hogg J. C., Chu F., Utokaparch S. et al. The nature of small-airway obstruction in chronic obstructive pulmonary disease. N. Engl. J. Med. 2004; 350: 2645-2653.
- Parr D. G., Stoel B. C., Stolk J., Stockley R. A. Pattern of emphysema distribution in alphal-antitrypsin deficiency influences lung function impairment. Am. J. Respir. Crit. Care Med. 2004; 170(11): 1172-1178.
- Miniati M., Monti S., Stolk J. et al. Value of chest radiography in phenotyping chronic obstructive pulmonary disease. Eur. Respir. J. 2008; 31: 509-515.
- Gevenois P. A., Vuyst P., de Maertelaer V. et al. Comparison of computed density and microscopic morphometry in pulmonary emphysema. Am. J. Respir. Crit. Care Med. 1996; 154: 187-192.
- Uppaluri R., Mitsa T., Sonka M. et al. Quantification of pulmonary emphysema from lung computed tomography images. Am. J. Respir. Crit. Care Med. 1997; 156: 248-254.
- Зарембо И. А. Хроническая обструктивная патология легких. В кн.: Кокосова А. А. (ред.) Пневмология в пожилом и старческом возрасте. СПб.: МедМассМедиа: 2005. 486.
- Loubeyre P., Pater M., Revel D. Thin-section CT detection of emphysema associated with bronchiectasis and correlation with pulmonary function tests. Chest 1996; 109: 360-365.
- Donaldson G. C., Seemungal T. A. R., Bhowmik A. et al. Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease. Thorax 2002; 57: 847-852.
![](/img/style/loading.gif)