Architectonics of cell subpopulations of peripheral blood in patients with autoimmune myocarditis: clinical and pathogenetic aspects
- Authors: Shogenov ZS1, Kekenazde NN1, Vorob'eva SE2, Usik MP2, Elbeik T3, Akhmedilova KA1, Mamonova EE2, Matsuura E4, Pal'tsev MA2, Suchkov SV2, Shogenov ZS2, Kekenadze NN2, Vorobyeva SE2, Usik MP2, Elbeik T2, Akhmedilova KA2, Mamonova EE2, Matsuura E2, Paltsev MA2, Suchkov SV2
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Affiliations:
- РГМУ, Москва
- ММА им. И. М. Сеченова
- Laboratory of Clinical Microbiology, University of San-Francisko Medical School, S.-F., CA., США
- Laboratory of Cell Chemistry, School of Medicine, Okayama University, Okayama, Япония
- Issue: Vol 80, No 12 (2008)
- Pages: 23-28
- Section: Editorial
- URL: https://journals.rcsi.science/0040-3660/article/view/30245
- ID: 30245
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Full Text
Abstract
Material and methods. Blood cell subpopulations were studied with flow cytometry in 99 blood samples from patients having different AIM variants and myocardiosclerosis as well as in 40 healthy donors.
Results. Severe (malignant) AIM was characterized by growing indices of T-/B lymphocyte activation, expression of activation markers on the cells of both differentiation lines, disproportions in composition of subpopulations of the immunoregulatory cells, parallel rise in specific weight of dendritic cells, reduced intensity of apoptosis of autoreactive T-lymphocytes. In benign AIM marked immunopathology was not found. This group can be considered as a separate variant of AIM course necessitating an individual approach to planning pathogenetically sound therapeutic and rehabilitation measures.
Conclusion. The study of activation markers expression on peripheral blood cells is superior to the study of endomyocardial biopsies providing a non-invasive method of immunodiagnosis.
Keywords
About the authors
Z S Shogenov
РГМУ, МоскваРГМУ, Москва
N N Kekenazde
РГМУ, МоскваРГМУ, Москва
S E Vorob'eva
ММА им. И. М. СеченоваММА им. И. М. Сеченова
M P Usik
ММА им. И. М. СеченоваММА им. И. М. Сеченова
T Elbeik
Laboratory of Clinical Microbiology, University of San-Francisko Medical School, S.-F., CA., СШАLaboratory of Clinical Microbiology, University of San-Francisko Medical School, S.-F., CA., США
K A Akhmedilova
РГМУ, МоскваРГМУ, Москва
E E Mamonova
ММА им. И. М. СеченоваММА им. И. М. Сеченова
E Matsuura
Laboratory of Cell Chemistry, School of Medicine, Okayama University, Okayama, ЯпонияLaboratory of Cell Chemistry, School of Medicine, Okayama University, Okayama, Япония
M A Pal'tsev
ММА им. И. М. СеченоваММА им. И. М. Сеченова
S V Suchkov
ММА им. И. М. СеченоваММА им. И. М. Сеченова
Z S Shogenov
N N Kekenadze
S E Vorobyeva
M P Usik
T Elbeik
K A Akhmedilova
E E Mamonova
E Matsuura
M A Paltsev
S V Suchkov
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