Polymorphic markers of GNB3 (C825T), AGTR1 (A1166C) and ACE (A2350G and I/D) genes in patients with arterial hypertension combined with diabetes mellitus type 2
- Authors: Karpov RS1,2, Puzyrev KV1,2, Koshelskaya ОA1,2, Makeeva OA1,2, Suslova TE1,2, Efimova EV1,2, Falkovskaya AY.1,2, Atroshenkov AV1,2
-
Affiliations:
- НИИ кардиологии ТНЦ СО РАМН
- НИИ медицинской генетики ТНЦ СО РАМН
- Issue: Vol 79, No 6 (2004)
- Pages: 30-35
- Section: Editorial
- URL: https://journals.rcsi.science/0040-3660/article/view/29821
- ID: 29821
Cite item
Full Text
Abstract
Conclusion. Polymorphic markers of ACE and GNB3 candidate genes influence clinical diversity of pathological signs in DM2 patients through modification of AH and LVH severity and the level of proinflammatory cytokines.
About the authors
R S Karpov
НИИ кардиологии ТНЦ СО РАМН; НИИ медицинской генетики ТНЦ СО РАМНТомск; НИИ кардиологии ТНЦ СО РАМН; НИИ медицинской генетики ТНЦ СО РАМН
K V Puzyrev
НИИ кардиологии ТНЦ СО РАМН; НИИ медицинской генетики ТНЦ СО РАМНТомск; НИИ кардиологии ТНЦ СО РАМН; НИИ медицинской генетики ТНЦ СО РАМН
О A Koshelskaya
НИИ кардиологии ТНЦ СО РАМН; НИИ медицинской генетики ТНЦ СО РАМНТомск; НИИ кардиологии ТНЦ СО РАМН; НИИ медицинской генетики ТНЦ СО РАМН
O A Makeeva
НИИ кардиологии ТНЦ СО РАМН; НИИ медицинской генетики ТНЦ СО РАМНТомск; НИИ кардиологии ТНЦ СО РАМН; НИИ медицинской генетики ТНЦ СО РАМН
T E Suslova
НИИ кардиологии ТНЦ СО РАМН; НИИ медицинской генетики ТНЦ СО РАМНТомск; НИИ кардиологии ТНЦ СО РАМН; НИИ медицинской генетики ТНЦ СО РАМН
E V Efimova
НИИ кардиологии ТНЦ СО РАМН; НИИ медицинской генетики ТНЦ СО РАМНТомск; НИИ кардиологии ТНЦ СО РАМН; НИИ медицинской генетики ТНЦ СО РАМН
A Yu Falkovskaya
НИИ кардиологии ТНЦ СО РАМН; НИИ медицинской генетики ТНЦ СО РАМНТомск; НИИ кардиологии ТНЦ СО РАМН; НИИ медицинской генетики ТНЦ СО РАМН
A V Atroshenkov
НИИ кардиологии ТНЦ СО РАМН; НИИ медицинской генетики ТНЦ СО РАМНТомск; НИИ кардиологии ТНЦ СО РАМН; НИИ медицинской генетики ТНЦ СО РАМН
References
- Schwartz К. On the pulse of genetic cardiology. Nat. Genet. 1994; 8: 110-111.
- Пузырев В. П. Генетика артериальной гипертонии (современные исследовательские парадигмы). Клин. мед. 2003; I: 12-18.
- Lorell В. В., Carabello В. A. Left ventricular hypertrophy: pathogenesis, detection, and prognosis. Circulation 2000; 102: 470-479.
- Furrukh S., Malik M. D., Carl J. et al. Renin-angiotensin system: genes to bedside. Am. Heart J. 1997; 134 (3): 514-527.
- Dzida G., Golon-Siekierska P., Puzniak A. et al. G-protein beta3 subunit gene C825T polymorphism is associated with arterial hypertension in Polish patients with type 2 diabetes mellitus. Med. Sci. Monit. 2002; 8: 597-602.
- Ohshiro Y., Ueda K., Wakasaki H. et al. Analysis of 825C/T polymorphism of G protein beta3 subunit in obese/diabetic Japanese. Biochem. Biophys. Res. Commun. 2001; 286: 678- 680.
- Siffert W. G-protein beta3 subunit 825T allele and hypertension. Curr. Hypertens. Rep. 2003; 5: 47-53.
- Wascher T. C., Paulweber В., Malaimare L. et al. Associations of a human G protein beta3 subunit dimorphism with insulin resistance and carotid atherosclerosis. Stroke 2003; 34: 605- 609.
- Yatani A., Codina J., Imoto Y. et al. G protein directly regulates mammalian cardiac calcium channels. Science 1987; 238: 1124-1131.
- Siffert W., Rosskopf A., Siffert G. Association of a human Gprotein beta3 subunit variant with hypertension. Nat. Genet. 1998; 18: 45-48.
- Yudkin J. S., Stehouwer С. D. A., Enters J. J. et al. C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction. A potential role for cytocines originating from adipose tissue. Arterioscler. Thromb. Vase. Biol. 1999; 19: 972-978.
- Levy D., Garrison R. J., Savage D. D. Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study. N. Engl. J. Med. 1990; 322: 1561-1566.
- Devereux R. В., Casale P. N., Kligfield P. Performance of primary and derived M-mode echocardiographic measurements for detection of left ventricular hypertrophy in necroprosical subjects and in patients with systemic hypertension, mitral regurgitation and dilate cardiomyopathy. Am. J. Cardiol. 1986; 57: 1388-1393.
- Devereux R. В., Richec N. Echocardiographic determination of left ventricular mass in man: anatomic validation of the method. Circulation 1977; 55: 613-618.
- Villard E., Tiret L., Visvikis S. et a!. Identification of new polymorphisms of the angiotensin I-converting enzyme (ACE) gene, and study of their relationship to plasma ACE levels by two-QTL segregation-linkage analysis. Am. J. Hum. Genet. 1996; 58: 1268-1278.
- Keavney В., McKenzie C., Connell J. M. С. et al. Measured haplotype analysis of the angiotensin-1 converting enzyme (ACE) gene. Hum. Mol. Genet. 1998; 7: 1745-1751.
- Takemoto Y., Sakatani M., Takami S. et al. Association between angiotensin II receptor gene polymorphism and serum angiotensin converting enzyme (SACE) activity in patients with sarcoidosis. Thorax 1998; 53: 459-462.
- Poch E., Gonzalez D., Gomez-Angelats E. et al. G-protein beta (3) subunit gene variant left ventricular hypertrophy in essential hypertension. Hypertension 2000; 35: 214-218.
- Пузырев К. В., Кошельская О. А., Ефимова Е. В. и др. Ассоциация инсерционно-делеционного полиморфизма гена конвертирующего ангиотензин-1 фермента с гипертрофией миокарда левого желудочка у больных артериальной гипертонией в сочетании с сахарным диабетом 2 типа. Сиб. мед. журн. 2003; 1: 45-49.
- Кобалава Ж. Д., Терещенко С. Н., Калинкин А. Л. Суточное мониторирование артериального давления: методические аспекты и клиническое значение / Под ред. В. С. Моисеева. М.: Медицина; 1997.
- Mayet J., Shaft M., Hughes A. D. et al. Left ventricular structure and function in previously untreated hypertensive patients: the importance of blood pressure, the nocturnal blood pressure dip, and heart rate. J. Cardiovasc. Risk 1995; 2: 255-261.
- Ishigami Т., Iwamoto T., Tamura K. et al. Angiotensin-I converting enzyme (ACE) gene polymorphism and essential hypertension in Japan. Ethnic difference of ACE genotype. Am. J. Hypertens. 1995; 8 (1): 95-97.
- Takami S., Katsua Т., Rakugi H. et al. Angiotensin II type 1 receptor gene polymoprhism is associate with increase of left ventricular hypertrophy but not with hypertension. Am. J. Hypertens. 1998; 11: 316-321.
- Biege J., Zilch O., Hohenbleicher H. et al. Genetic variants of the renin-angiotensin system and ambulatory blood pressure in essential hypertension. J. Hypertens. 1997; 5: 503-508.
- Rigat В., Hubert C., Alhenc-Gelas F. et al. An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J. Clin. Invest. 1990; 86: 1343-1346.
- Tiret L., Rigat В., Visvikis S. et al. Evidence from combined segregation and linkage analysis that a variant of ACE gene controls plasma ACE levels. Am. J. Hum. Genet. 1992; 51: 197-205.
- Castellano M., Muisan M. L., Beschi M. et al. Angiotensin II type 1 receptor gene АП66С polymorphism: relationship with blood pressure and cardiovascular structure. Hypertension 1996; 28: 1076-1080.
- Tiret L., Blanc H., Ruidavets J. B. et al. Gene polymorphisms of the renin-angiotensin system in relation to hypertension and parental history of myocardial infarction and stroke: the PEGASE study. J. Hypertens. 1998; 16 (1): 37-44.
- Siffert W. G-protein beta-3 subunit 825T allele, hypertension, obesity, and diabetic nephropathy. Nephrol. Dial. Transplant. 2000; 15: 1298-1306.
- Schunkert H., Hense H. W., Doring A. et al. Association between a polymorphism in the G protein beta 3 subunit gene and lower renin and elevated diastolic blood pressure levels. Hypertension 1998; 32: 510-513.
- Шляхто Е. В., Шварц Е. И., Соколова Л. А. и др. Изучение ассоциации полиморфного маркера С825Т гена бета-3 субъединицы G-белка с гипертрофией миокарда левого желудочка у больных с гипертонической болезнью. Кардиология 2003; 1: 44-46.
![](/img/style/loading.gif)