Email this article Persistence of various infective agents in blood mononuclear leukocytes in debute of rheumatoid arthritis
- Authors: Petrov AV1, Dudar LV1, Maly KD1
-
Affiliations:
- Крымский государственный медицинский университет им. С. И. Георгиевского
- Issue: Vol 79, No 5 (2004)
- Pages: 32-35
- Section: Editorial
- URL: https://journals.rcsi.science/0040-3660/article/view/29817
- ID: 29817
Cite item
Full Text
Abstract
Aim. To study persistence in blood mononuclear leukocytes (ML) of Herpesviridae viruses (cytomegalovirus-CMV, herpes virus of type I and II, Epstein-Barr virus-EBV, hepatitis В and С viruses, Mycoplasma arthritidis-Ma, , Mycoplasma fermentans-Mf, Ureaplasma urealiticum-U, Chlamidia trachomatis-Ct).
Material and methods. 56 patients with debute of rheumatoid arthritis (RA) and 30 healthy persons were examined using methods of direct and indirect immunofluorescence, polymerase chain reaction and enzyme immunoassay.
Results. In patients with early RA persistence of infective agents in blood ML was found high (67.9%). Persistance of the viruses was studied for 1.5-2 years. Features of the clinical course of the disease were specified for various infective agents: seronegativeness in persistence of Ma, Mf and U, high activity and frequent development of systemic manifestations of RA in persistence of Herpesviridae viruses, rapid progression of bone destruction in persistence of Ct.
Conclusion. Carriage of Herpesviridae was associated with high activity of inflammatory process, of Chlamidia - with rapid bone destruction, of mycoplsma and ureaplasma - with unchanged rate of progression. Eradication of Herpes viruses, CMV, EBV and CT is indicated.
Material and methods. 56 patients with debute of rheumatoid arthritis (RA) and 30 healthy persons were examined using methods of direct and indirect immunofluorescence, polymerase chain reaction and enzyme immunoassay.
Results. In patients with early RA persistence of infective agents in blood ML was found high (67.9%). Persistance of the viruses was studied for 1.5-2 years. Features of the clinical course of the disease were specified for various infective agents: seronegativeness in persistence of Ma, Mf and U, high activity and frequent development of systemic manifestations of RA in persistence of Herpesviridae viruses, rapid progression of bone destruction in persistence of Ct.
Conclusion. Carriage of Herpesviridae was associated with high activity of inflammatory process, of Chlamidia - with rapid bone destruction, of mycoplsma and ureaplasma - with unchanged rate of progression. Eradication of Herpes viruses, CMV, EBV and CT is indicated.
Keywords
About the authors
A V Petrov
Крымский государственный медицинский университет им. С. И. ГеоргиевскогоСимферополь; Крымский государственный медицинский университет им. С. И. Георгиевского
L V Dudar
Крымский государственный медицинский университет им. С. И. ГеоргиевскогоСимферополь; Крымский государственный медицинский университет им. С. И. Георгиевского
K D Maly
Крымский государственный медицинский университет им. С. И. ГеоргиевскогоСимферополь; Крымский государственный медицинский университет им. С. И. Георгиевского
References
- Маянский А. Н., Бурков А. Н., Астафьев Д. Г., Рассанов С. П. Персистенции вирусов: иммунологические и патогенетические аспекты. Клин. мед. 1998; 12: 19-25.
- Горячев Д. В., Егорова О. Н., Балабанова Р. М. Роль вирусов в развитии ревматоидного артрита. Тер. арх. 2001; 2: 72-78.
- Musiani М., Zerbini N., Fern S., Plazzi M. Comparison of the immune response to of Epstein-Barr virus and cytomegalovirus in sera and synovial fluids of patients with rheumatoid arthritis patients. Ann. Rheum. Dis. 1987; 46: 837-842.
- Tsai Y. Т., Chiang B. L., Kao Y. F., Hsieh К. Н. Detection of Epstein-Barr virus and cytomegalovirus genom in white blood cells from patiens with juvenil rheumatoid arthritis and childhood systemic lupus erytematosis. Int. Arch. Allergy Immunol. 1995; 106: 235-240.
- Егорова О. Н., Балабанова Р. М., Чувыров Г. Н. Значение выявления при ревматических заболеваниях антител к вирусам семейства Herpesviridae. Тер. арх. 1998; 5: 41-45.
- Прозоровский С. В., Раковская И. В., Вульфович Ю. В. Медицинская микоплазмология. М.; 1999.
- Arnett F. С., Edworthy S. M., Bloch D. A. et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthr. and Rheum. 1988; 31: 315-324.
- Van der Heijde D. Plain X-rays in rheumatoid arthritis: overview of scoring methods, their reliability and applicability. Baillieres Clin. Rheumatol. 1996; 10: 435-453.
