Changes in inflammatory activity of rheumatoid arthritis at early stages of basic therapy with leflunomide
- Authors: Balabanova RM1,2,3, Makolkin VI1,2,3, Shostak NA1,2,3, Chichasova NV1,2,3, Olyunin Y.A1,2,3, Goryachev DV1,2,3, Loginova ТК1,2,3, Ryabkova AA1,2,3, Petukhova NV1,2,3, Menshikova IV1,2,3, Igolkina EV1,2,3, Chizhova KA1,2,3, Nasonov EL1,2,3
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Affiliations:
- Институт ревматологии РАМН
- ММА им. И. М. Сеченова
- РГМУ
- Issue: Vol 79, No 5 (2004)
- Pages: 28-32
- Section: Editorial
- URL: https://journals.rcsi.science/0040-3660/article/view/29809
- ID: 29809
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Full Text
Abstract
Material and methods. The study included 200 RA patients treated in four Moscow clinical centers. Leflunomide was given in a dose of 100 mg/day for 3 days, then 20 mg/day for 16 weeks. The activity of the disease according to the criterion DAS 28 was assessed before the treatmend and 4, 8, 12 and 16 weeks after the treatment start.
Results. RA activity diminished considerably after one month of leflunomide treatment. Later, the articular syndrome continued to improve. A significant improvement by DAS 28 was observed after 16 weeks of the treatment in 65% (129 of 200) patients, high RA activity persisted only in 17 of 90 patients.
Conclusion. Leflunomide reduces articular inflammation and raises RA patients' quality of life at early stages of the treatment. This reduction continued for 4 months of the study. Therefore, adequate assessment of leflunomide efficacy should be made only after 4-6 months of therapy.
Keywords
About the authors
R M Balabanova
Институт ревматологии РАМН; ММА им. И. М. Сеченова; РГМУМосква; Институт ревматологии РАМН; ММА им. И. М. Сеченова; РГМУ
V I Makolkin
Институт ревматологии РАМН; ММА им. И. М. Сеченова; РГМУМосква; Институт ревматологии РАМН; ММА им. И. М. Сеченова; РГМУ
N A Shostak
Институт ревматологии РАМН; ММА им. И. М. Сеченова; РГМУМосква; Институт ревматологии РАМН; ММА им. И. М. Сеченова; РГМУ
N V Chichasova
Институт ревматологии РАМН; ММА им. И. М. Сеченова; РГМУМосква; Институт ревматологии РАМН; ММА им. И. М. Сеченова; РГМУ
Yu A Olyunin
Институт ревматологии РАМН; ММА им. И. М. Сеченова; РГМУМосква; Институт ревматологии РАМН; ММА им. И. М. Сеченова; РГМУ
D V Goryachev
Институт ревматологии РАМН; ММА им. И. М. Сеченова; РГМУМосква; Институт ревматологии РАМН; ММА им. И. М. Сеченова; РГМУ
Т К Loginova
Институт ревматологии РАМН; ММА им. И. М. Сеченова; РГМУМосква; Институт ревматологии РАМН; ММА им. И. М. Сеченова; РГМУ
A A Ryabkova
Институт ревматологии РАМН; ММА им. И. М. Сеченова; РГМУМосква; Институт ревматологии РАМН; ММА им. И. М. Сеченова; РГМУ
N V Petukhova
Институт ревматологии РАМН; ММА им. И. М. Сеченова; РГМУМосква; Институт ревматологии РАМН; ММА им. И. М. Сеченова; РГМУ
I V Menshikova
Институт ревматологии РАМН; ММА им. И. М. Сеченова; РГМУМосква; Институт ревматологии РАМН; ММА им. И. М. Сеченова; РГМУ
E V Igolkina
Институт ревматологии РАМН; ММА им. И. М. Сеченова; РГМУМосква; Институт ревматологии РАМН; ММА им. И. М. Сеченова; РГМУ
K A Chizhova
Институт ревматологии РАМН; ММА им. И. М. Сеченова; РГМУМосква; Институт ревматологии РАМН; ММА им. И. М. Сеченова; РГМУ
E L Nasonov
Институт ревматологии РАМН; ММА им. И. М. Сеченова; РГМУМосква; Институт ревматологии РАМН; ММА им. И. М. Сеченова; РГМУ
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