电邮这篇文章 Characteristics of tuberculosis running with HIV-infection
- 作者: Schelkanova AI1, Kravchenko AV2
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隶属关系:
- Московская областная туберкулезная больница
- Федеральный научно-методический центр по профилактике и борьбе со СПИДом Минздрава РФ
- 期: 卷 79, 编号 4 (2004)
- 页面: 20-24
- 栏目: Editorial
- URL: https://journals.rcsi.science/0040-3660/article/view/29779
- ID: 29779
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详细
Aim. To analyse social, clinical, x-ray and immunological features of tuberculosis (ТВ) in 117 patients from the Moscow region with concurrent HIV-infection.
Material and methods. The patients were divided into 3 groups depending on the time of ТВ and HIV-infection detection in relation to each other. Group 1 patients (20.5%) had suffered from ТВ for 2 years before detection of HIV-infection, group 2 patients (51%) were diagnosed simultaneously for 1-2 years to have both diseases, group 3 patients (28%) had suffered from HIV-infection for 2 years before the diagnosis of ТВ.
Results. It was established that the course of ТВ with associated HIV-infection depends not only on severity of immunodeficiency caused by HIV but also on characteristics of M.tuberculosis and social status of the patients. Most of ТВ/HIV patients were drug addicts, alcoholicts, convicts. Unfavourable social status in the above patients, contact with ТВ (70%) and its realization in a penitentiary carry a high risk of drug-resistant ТВ. High prevalence of destructive ТВ forms (64%), among them large caverns were in 77%, may result from M. tuberculosis resistance to antituberculous drugs and unfavourable social status of the patients. Reduction of the number of CD4-cells lowers the ability to form caverns and fibrosis and promotes dissemination of M. tuberculosis bacteria with formation of inflammation foci in different organs and systems. Conclusion. Four clinical models of ТВ/HIV onset and course are suggested.
Material and methods. The patients were divided into 3 groups depending on the time of ТВ and HIV-infection detection in relation to each other. Group 1 patients (20.5%) had suffered from ТВ for 2 years before detection of HIV-infection, group 2 patients (51%) were diagnosed simultaneously for 1-2 years to have both diseases, group 3 patients (28%) had suffered from HIV-infection for 2 years before the diagnosis of ТВ.
Results. It was established that the course of ТВ with associated HIV-infection depends not only on severity of immunodeficiency caused by HIV but also on characteristics of M.tuberculosis and social status of the patients. Most of ТВ/HIV patients were drug addicts, alcoholicts, convicts. Unfavourable social status in the above patients, contact with ТВ (70%) and its realization in a penitentiary carry a high risk of drug-resistant ТВ. High prevalence of destructive ТВ forms (64%), among them large caverns were in 77%, may result from M. tuberculosis resistance to antituberculous drugs and unfavourable social status of the patients. Reduction of the number of CD4-cells lowers the ability to form caverns and fibrosis and promotes dissemination of M. tuberculosis bacteria with formation of inflammation foci in different organs and systems. Conclusion. Four clinical models of ТВ/HIV onset and course are suggested.
作者简介
A Schelkanova
Московская областная туберкулезная больницаМосковская областная туберкулезная больница
A Kravchenko
Федеральный научно-методический центр по профилактике и борьбе со СПИДом Минздрава РФМосква; Федеральный научно-методический центр по профилактике и борьбе со СПИДом Минздрава РФ
参考
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