电邮这篇文章 Autoimmune manifestations in acute viralhepatitides
- 作者: Volchkova Y.V1, Allenov MN1, Umbetova КТ1, Ivanovo IV1, Pak SG1
-
隶属关系:
- ММА им И. М. Сеченова
- 期: 卷 78, 编号 11 (2003)
- 页面: 11-14
- 栏目: Editorial
- URL: https://journals.rcsi.science/0040-3660/article/view/29680
- ID: 29680
如何引用文章
全文:
详细
Aim. To study autoimmune reactions in patients with acute viral hepatitis A, B, and С in the dynamics of an infectious process.
Materials and methods. 134 patients with acute viral hepatitides of various etiology were examined.
Among them there were 36 patients with acute viral hepatitis A, 40 with B, and 58 with viral hepatitis С
Antinuclear antibodies (ANA), antismooth muscle antibodies (SMA), and antimitochondrial antibodies
(AMA) were determined by immunofluoresence assay using the test systems ATS COMVI-1, IMMCO
diagnostics (USA). Serum rheumatoid factor was detected by the semiquantitative latex-agglutination
test on a slide manufactured by the Human"firm (Germany). Cryoglobulins were identified by the
qualitative visual method.
Results. SMA, ANA were detected in the diagnostically significant titers (1:40-1:160) in patients with
acute viral hepatitis A, B, and С A distinction of autoimmune manifestations was ascertained in viral
hepatitis C. It has been demonstrated that in 71% of the patients cryoglobulins appear in the acute period of the disease and, in their presence, rheumatoid factor was found in 17.2% and 6.9% exhibited
anti-LKM-1 and AMA.
Conclusion. The presented data on the nature and time course of changes in autoimmune reactions in
patients with acute viral hepatitis A, B, and С during an infectious process suggest that autoimmune
disorders are characteristic of viral hepatic lesions just at the early stages of the disease irrespective of N 4.
its etiology and play a prominent role in the pathogenesis of these nosological entities.
Materials and methods. 134 patients with acute viral hepatitides of various etiology were examined.
Among them there were 36 patients with acute viral hepatitis A, 40 with B, and 58 with viral hepatitis С
Antinuclear antibodies (ANA), antismooth muscle antibodies (SMA), and antimitochondrial antibodies
(AMA) were determined by immunofluoresence assay using the test systems ATS COMVI-1, IMMCO
diagnostics (USA). Serum rheumatoid factor was detected by the semiquantitative latex-agglutination
test on a slide manufactured by the Human"firm (Germany). Cryoglobulins were identified by the
qualitative visual method.
Results. SMA, ANA were detected in the diagnostically significant titers (1:40-1:160) in patients with
acute viral hepatitis A, B, and С A distinction of autoimmune manifestations was ascertained in viral
hepatitis C. It has been demonstrated that in 71% of the patients cryoglobulins appear in the acute period of the disease and, in their presence, rheumatoid factor was found in 17.2% and 6.9% exhibited
anti-LKM-1 and AMA.
Conclusion. The presented data on the nature and time course of changes in autoimmune reactions in
patients with acute viral hepatitis A, B, and С during an infectious process suggest that autoimmune
disorders are characteristic of viral hepatic lesions just at the early stages of the disease irrespective of N 4.
its etiology and play a prominent role in the pathogenesis of these nosological entities.
作者简介
Ye Volchkova
ММА им И. М. СеченоваММА им И. М. Сеченова
M Allenov
ММА им И. М. СеченоваММА им И. М. Сеченова
К Umbetova
ММА им И. М. СеченоваММА им И. М. Сеченова
I Ivanovo
ММА им И. М. СеченоваММА им И. М. Сеченова
S Pak
ММА им И. М. СеченоваММА им И. М. Сеченова
参考
- Ройт А., Бростофф Дж., Meiii Д. Иммунология. М.: Мир; 2000.
- Апросина 3. Г. Хронический активный гепатит как системное заболевание. М.; 1981.
- Буеверов А. О. Рос. журн. гастроэтерол. гепатол., колопроктол. 1998; 5: 18-20
- Серов В. В., Апросина 3. Г. Хронический вирусный гепатит. М.; 2002. 47-96.
- Manns M. P. Hepatotropic viruses and autoimmunity 1997. J. of viral hepatit. 1997; 4 (suppl. 1): 7-10.
- Vento S., Garofano T. et al. Identification of hepatitis A virus a trigger for autoimmune chronic hepatitis 1 in susceptible individuals. 1991; 337: 1183-1186.
- Clifford B. D., Donahul D. et al. High prevalence of serological markers of autoimmunity in patients with chronic hepatitis С Hepatology 1995; 613-619.
- Lunel F., Musset L. et al. Cryoglobulinemia in chronic liver diseases: role of hepatitis С virus liver damage. Gasroenterology 1994; 106: 1291-1300.
- Seelig R., Rent M. et al. Anti-LKM-1 antibodies determined by use of recombinant P450 IID6 in EL1SA and western blot and their association with anti-HCV and HCV RNA. Clin. Exp. Immunol. 1993; 92: 373-380.
- Шерлок III., Дули Док. Заболевания печени и желчных пу- тей. М.: Гэотар медицина; 1999.
- Lohse A. W., Gerken G. et al. Relation between autoimmune liver disease and viral hepatitis: clinical and serological characteristics in 859 patients. Gasroenterology 1995; 33: 527-533.
- Соринсон С. Н. и др. Латентная фаза хронического гепатита С: критерии диагностики и терапевтическая тактика. Вирус, гепатиты: Информ. бюл. 1999; 1 (5): 17-21.
- Игнатова Т. М. Хронический гепатит С: клинико-морфологическая характеристика, течение и лечение: Автореф. дис. д-ра мед. наук. М.; 2000.
- Zignego A. L., Brechot С. Extrahepatic manifestations of HCV infection: facts and controversies. J. Hepatol. 1999; 31: 369- 376.
- Donada C, Crucitti A. et al. Systemic manifestations and liver disease in patients with chronic hepatitis С and type II or 111 mixed crioglobulinemia. J. Viral. Hepatol. 1998; 25: 972-975.
- Апросина З. Г. Аутоиммунный гепатит (история изучения, патогенез, роль вирусов, клинико-морфологическая характеристика). Вирус, гепатиты: Информ. бюл. 1998; 3 (4): 12-21.
- Пак С. Г., Белая О. Ф., Волчкова Е. Ф. и др. Клинико-патогенетическое значение циркулирующих ЛПС-антигенов патогенных кишечных бактерий при острых вирусных гепатитах. Рос. журн. гастроэнтерол., гепатол., колопроктол. 2002; 12 (№ 1, прил. 16: Материалы VII Российской конф. "Гепатология сегодня"): 13.
- Pawlotsky J. M., Deforges M. et al. Hepatitis C virus can mimic type 1 (anti-nuclear antibody positive) autoimmune chronic active hepatitis. Gut 1993; 34 (suppl. 2): 66-68.
- Kammer A. R., Van der Burg S. H. et al. Molecular mimicry of cytochrome P450 by hepatitis С virus at the level of cytotoxic T cell recognition. J. Exp. Med. 1999; 190: 169-176.
补充文件
