Long-term results of structum® administration (data from a multicenter trial)
- Authors: Alekseeva LI1, Arkhangelskaya GS2, Davydova AF3, Karmiltseva EA4, Kogan КМ5, Mazurov VI6, Rebrov AP7, Ryabitseva OF8, Shemerovskaya TG9, Yakushin SS10, Nasonova VA1, Soldatov DG11
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Affiliations:
- Институт ревматологии РАМН
- Ревматологическое отделение МСЧ №12, Самара
- Краснодарский краевой ревматологический центр
- Городскойревматологический центр, Екатеринбург
- Московский городской кардиоревматологическийцентр при ГКБ №1 им. Н. И. Пирогова
- Санкт-Петербургская МАПО
- Саратовский государственный медицинский университет
- Свердловский областной ревматологический центр
- Городскойревматологический центр, Санкт-Петербург
- Рязанский государственный медицинский университет
- Лаборатория "Пьер Фабр" Москва
- Issue: Vol 78, No 9 (2003)
- Pages: 82-86
- Section: Editorial
- URL: https://journals.rcsi.science/0040-3660/article/view/29669
- ID: 29669
Cite item
Full Text
Abstract
of the knee and hip joints as well as structum effects on OA course and that of concomitant diseases.
Material and methods. The duration of a clinical response to structum after the end of the treatment
and its effect on OA and concominant diseases course were studied for 12 months in 9 centers participating
in the study of the drug efficacy and tolerance in patients with gon- and coxarthrosis in an open
multicenter randomized controlled 6-month trial. Out of 555 patients with OA of the knee and hip
joints enrolled in the first study, the examination covered 373 patients: 159 patients of the test group
treated for 6 months with structum and 214 controls. By basic clinical parameters the groups were similar.
Clinical examination was made after structum treatment and 12 months later and included assessment
of the number of exacerbations, hospitalizations, outpatient consultations, days of temporary
disability for OA, pain in the joints while walking and at rest by the visual scale, Leken's functional
index, x-ray pictures of the joints, administration of nonsteroidal anti-inflammatory drugs (NSAID),
exacerbations of concomitant diseases (gastrointestinal diseases, arterial hypertension, ischemic heart
disease).
Results. An overall functional Leken's index in patients with gon- and coxarthrosis given structum 12
months after the treatment did not reach the initial values as well as pain and daily need in NSAID.
Structum effect in patients with knee joint OA persisted for 4.6 months , in hip joint OA - 4.1 months;
in patients with stage /-// the effect lasted longer than in stage III (5.2 and 4.6 months vs 4.17 and
3.24 months, respectively. Even short-term therapy with structum reduced the number of further exacerbations,
hospitalizations and visits to their doctor. 12 months after structum therapy the effect persisted
in 40% patients. Frequency of exacerbations of the concomitant diseases was less than in patients
on continuous NSAID.
Conclusion. Structum is a highly effective drug against OA as it acts long, reduces frequency of exacerbations,
hospitalizations, visits to the doctor, duration of disability, NSAID requirement and improves
the course of some concomitant diseases.
Keywords
About the authors
L I Alekseeva
Институт ревматологии РАМНИнститут ревматологии РАМН
G S Arkhangelskaya
Ревматологическое отделение МСЧ №12, Самараканд. мед. наук; Ревматологическое отделение МСЧ №12, Самара
A F Davydova
Краснодарский краевой ревматологический центрканд. мед. наук; Краснодарский краевой ревматологический центр
E A Karmiltseva
Городскойревматологический центр, Екатеринбургканд. мед. наук; Городскойревматологический центр, Екатеринбург
К М Kogan
Московский городской кардиоревматологическийцентр при ГКБ №1 им. Н. И. Пироговаканд. мед. наук; Московский городской кардиоревматологическийцентр при ГКБ №1 им. Н. И. Пирогова
V I Mazurov
Санкт-Петербургская МАПОпроф. В; Санкт-Петербургская МАПО
A P Rebrov
Саратовский государственный медицинский университетпроф.; Саратовский государственный медицинский университет
O F Ryabitseva
Свердловский областной ревматологический центрканд. мед. наук; Свердловский областной ревматологический центр
T G Shemerovskaya
Городскойревматологический центр, Санкт-Петербургканд. мед. наук; Городскойревматологический центр, Санкт-Петербург
S S Yakushin
Рязанский государственный медицинский университетпроф.; Рязанский государственный медицинский университет
V A Nasonova
Институт ревматологии РАМНИнститут ревматологии РАМН
D G Soldatov
Лаборатория "Пьер Фабр" Москваканд. мед. наук; Лаборатория "Пьер Фабр" Москва
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