电邮这篇文章 Experience with ixel (milnaciprane hydrochloride) treatment of poststroke depression
- 作者: Gekht АВ1, Sorokina IB1, Bogolepova AN1, Gudkova AA1
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- РГМУ
- 期: 卷 78, 编号 10 (2003)
- 页面: 34-37
- 栏目: Editorial
- URL: https://journals.rcsi.science/0040-3660/article/view/29657
- ID: 29657
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Aim. To evaluate antidepressive efficacy ofixel in patients with poststroke depression (PSD).
Material and methods. The study included 59 PSD patients aged 43- 79 years divided into two
groups: the test group (31 patients) treated with antidepressive drugs and the control group (28 patients) was not treated with such drugs. The test group took a two-month treatment with oral ixel in a
dose 100 mg/day. The neurological status was assessed by Lindmark scale (LS), severity of depression - by Hamilton scale (HS).
Results. On ixel treatment day 10-14 the patients felt better, by the treatment day 60 depression disappeared in 60.9%, only borderline conditions were seen in 39.1%. Mean score by HS fell from 15.8
to 5.7. The controls showed moderate reduction of some symptoms of depression, mean score by HS
descreased insignificantly (from 14.5 to 13.4). By LS, significant differences between the groups were
not registered. Side effects arose in 10 patients, 6 of them withdrew.
Conclusion. Ixel is an effective drug against depression in stroke survivors.
Material and methods. The study included 59 PSD patients aged 43- 79 years divided into two
groups: the test group (31 patients) treated with antidepressive drugs and the control group (28 patients) was not treated with such drugs. The test group took a two-month treatment with oral ixel in a
dose 100 mg/day. The neurological status was assessed by Lindmark scale (LS), severity of depression - by Hamilton scale (HS).
Results. On ixel treatment day 10-14 the patients felt better, by the treatment day 60 depression disappeared in 60.9%, only borderline conditions were seen in 39.1%. Mean score by HS fell from 15.8
to 5.7. The controls showed moderate reduction of some symptoms of depression, mean score by HS
descreased insignificantly (from 14.5 to 13.4). By LS, significant differences between the groups were
not registered. Side effects arose in 10 patients, 6 of them withdrew.
Conclusion. Ixel is an effective drug against depression in stroke survivors.
参考
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