Therapies of chronic thromboembolic pulmonary hypertension: A review

Cover Page

Cite item

Full Text

Abstract

The article addresses therapies for chronic thromboembolic pulmonary hypertension (CTEPH). The main challenges of patient management at various stages of diagnosis and treatment and the prevalence and pathogenesis of CTEPH are described. Immediate and long-term outcomes after treatment are evaluated. The study aims to present current therapies for CTEPH.

About the authors

Oksana Ya. Vasiltseva

Meshalkin National Medical Research Center

Email: vasiltsevaoy@gmail.com
ORCID iD: 0000-0002-2932-3159

доктор медицинских наук, ведущий научный сотр.

Russian Federation, Moscow

Alexander G. Edemskiy

Meshalkin National Medical Research Center

Email: a_edemskiy@meshalkin.ru
ORCID iD: 0000-0002-6661-7826

кандидат медицинских наук, врач – сердечно-сосудистый хирург

Russian Federation, Moscow

Devran F. Zeinalov

Meshalkin National Medical Research Center

Author for correspondence.
Email: devranzeynalov@mail.ru
ORCID iD: 0000-0002-0315-6145

врач-кардиолог

Russian Federation, Moscow

Elena N. Kliver

Meshalkin National Medical Research Center

Email: e_kliver@meshalkin.ru
ORCID iD: 0000-0002-1119-4870

доктор медицинских наук, врач-кардиолог

Russian Federation, Moscow

Wladimir Yu. Ussov

Meshalkin National Medical Research Center

Email: usov_v@meshalkin.ru
ORCID iD: 0000-0001-7978-5514

доктор медицинских наук, профессор, главный научный сотр.

Russian Federation, Moscow

Denis S. Grankin

Meshalkin National Medical Research Center

Email: d_grankin@meshalkin.ru
ORCID iD: 0000-0002-0083-8888

кандидат медицинских наук, врач по рентгенэндоваскулярной диагностике и лечению

Russian Federation, Moscow

Dmitry A. Sirota

Meshalkin National Medical Research Center

Email: d_sirota@meshalkin.ru
ORCID iD: 0000-0002-9940-3541

кандидат медицинских наук, врач – сердечно-сосудистый хирург

Russian Federation, Moscow

Aleksandr M. Chernyavskiy

Meshalkin National Medical Research Center

Email: a_cherniavsky@meshalkin.ru
ORCID iD: 0000-0001-9818-8678

чл.-кор. РАН, доктор мед. наук, профессор, генеральный директор

Russian Federation, Moscow

References

  1. Pepke-Zaba J, Delcroix M, Lang I, et al. Chronic thromboembolic pulmonary hypertension (CTEPH): results from an international prospective registry. Circulation. 2011;124(18):1973-81. doi: 10.1161/CIRCULATIONAHA.110.015008
  2. Чазова И.Е., Мартынюк Т.В., Акчурин Р.С., и др. Клинические рекомендации по диагностике и лечению хронической тромбоэмболической легочной гипертензии (I часть). Терапевтический архив. 2016;88(9):90-101 [Chazova IE, Martynyuk TV. Clinical guidelines for the diagnosis and treatment of chronic thromboembolic pulmonary hypertension (Part 1). Terapevticheskii Arkhiv (Ter. Arkh.). 2016;88(9):90-101 (in Russian)]. doi: 10.17116/terarkh201688990-101.
  3. Simonneau G, Galiè N, Rubin LJ, et al. Clinical classification of pulmonary hypertension. J Am Coll Cardiol. 2004;43(Suppl. 12):5-12. doi: 10.1016/j.jacc.2004.02.037
  4. Чазова И.Е., Мартынюк Т.В., Валиева З.С., и др. Евразийские рекомендации по диагностике и лечению хронической тромбоэмболической легочной гипертензии (2020). Евразийский кардиологический журнал. 2021;(1):6-43 [Chazova IE, Martynyuk TV, Valieva ZS, et al. Eurasian Association of Cardiology (EAC) Guidelines for the diagnosis and treatment of chronic thromboembolic pulmonary hypertension (2020). Eur Heart J. 2021;(1):6-43 (in Russian)]. doi: 10.38109/2225-1685-2021-1-6-43
  5. Humbert M, Kovacs G, Hoeper MM, et al. 2022 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension. Eur Heart J. 2022;43(38):3618-731. doi: 10.1093/eurheartj/ehac237
  6. Wilkens H, Konstantinides S, Lang IM, et al. Chronic thromboembolic pulmonary hypertension (CTEPH): updated recommendations from the Cologne Consensus Conference 2018. Int J Cardiol. 2018;272S:69-78. doi: 10.1016/j.ijcard.2018.08.079
  7. Giordano NJ, Jansson PS, Young MN, et al. Epidemiology, pathophysiology, stratification, and natural history of pulmonary embolism. Tech Vasc Interv Radiol. 2017;20(3):135-40. doi: 10.1053/j.tvir.2017.07.002
  8. Simonneau G, Torbicki A, Dorfmüller P, Kim N. The pathophysiology of chronic thromboembolic pulmonary hypertension. Eur Respir Rev. 2017;26(143):160112. doi: 10.1183/16000617.0112-2016
  9. Zhang M, Wang N, Zhai Z, et al. Incidence and risk factors of chronic thromboembolic pulmonary hypertension after acute pulmonary embolism: a systematic review and meta-analysis of cohort studies. J Thorac Dis. 2018;10(8):4751-63. doi: 10.21037/jtd.2018.07.106
  10. Pengo V, Lensing AWA, Prins MH, et al. Incidence of chronic thromboembolic pulmonary hypertension after pulmonary embolism. N Engl J Med. 2004;350(22):2257-64. doi: 10.1056/nejmoa032274
  11. Becattini C, Agnelli G, Pesavento R, et al. Incidence of chronic thromboembolic pulmonary hypertension after a first episode of pulmonary embolism. Chest. 2006;130(1):172-5. doi: 10.1378/chest.130.1.172
  12. Ende-Verhaar YM, Cannegieter SC, Noordegraaf AV, et al. Incidence of chronic thromboembolic pulmonary hypertension after acute pulmonary embolism: a contemporary view of the published literature. Eur Respir J. 2017;49(2):1601792. doi: 10.1183/13993003.01792-2016
  13. Escribano-Subias P, Blanco I, López-Meseguer M, et al. Survival in pulmonary hypertension in Spain: insights from the Spanish registry. Eur Respir J. 2012;40(3):596-603. doi: 10.1183/09031936.00101211
  14. Condliffe R, Kiely DG, Gibbs JSR, et al. Improved outcomes in medically and surgically treated chronic thromboembolic pulmonary hypertension. Am J Respir Crit Care Med. 2008;177(10):1122-7. doi: 10.1164/rccm.200712-1841OC
  15. Madani MM. Pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension: state-of-the-art 2020. Pulm Circ. 2021;11(2):20458940211007372. doi: 10.1177/20458940211007372
  16. Kim NH, Delcroix M, Jais X, et al. Chronic thromboembolic pulmonary hypertension. Eur Respir J. 2019;53(1):1801915. doi: 10.1183/13993003.01915-2018
  17. Васильцева О.Я., Едемский А.Г., Гранкин Д.С., и др. Путь от тромбоэмболии легочной артерии к хронической тромбоэмболической легочной гипертензии: факторы риска. Патология кровообращения и кардиохирургия. 2021;25(3):11-9 [Kliver EN, Edemskiy AG, Grankin DS, et al. From pulmonary embolism to chronic thromboembolic pulmonary hypertension: risk factors. Patologiya krovoobrashcheniya i kardiokhirurgiya = Circulation Pathology and Cardiac Surgery. 2021;25(3):11-9 (in Russian)]. doi: 10.21688/1681-3472-2021-3-11-19
  18. Madani MM, Auger WR, Pretorius V, et al. Pulmonary endarterectomy: recent changes in a single institution’s experience of more than 2,700 patients. Ann Thorac Surg. 2012;94(1):97-103. doi: 10.1016/j.athoracsur.2012.04.004
  19. Cannon JE, Su L, Kiely DG, et al. Dynamic Risk Stratification of Patient Long-Term Outcome After Pulmonary Endarterectomy: Results From the United Kingdom National Cohort. Circulation. 2016;133(8):1761-71. doi: 10.1161/CIRCULATIONAHA.115.019470
  20. Brookes JDL, Li C, Chung STW, et al. Pulmonary thromboendarterectomy for chronic thromboembolic pulmonary hypertension: a systematic review. Ann Cardiothorac Surg. 2022;11(2):68-81. doi: 10.21037/acs-2021-pte-25
  21. Martin-Suarez S, Loforte A, Cavalli GG, et al. Therapeutic alternatives in chronic thromboembolic pulmonary hypertension: from pulmonary endarterectomy to balloon pulmonary angioplasty to medical therapy. State of the art from a multidisciplinary team. Ann Cardiothorac Surg. 2022;11(2):120-7. doi: 10.21037/acs-2021-pte-23
  22. Чернявский А.М., Едемский А.Г., Новикова Н.В., и др. Хирургическое лечение хронической тромбоэмболической легочной гипертензии. Новосибирск: СО РАН, 2019 [Cherniavskii AM, Edemskii AG, Novikova NV, et al. Khirurgicheskoe lechenie khronicheskoi tromboembolicheskoi legochnoi gipertenzii. Novosibirsk: SO RAN, 2019 (in Russian)].
  23. Едемский А.Г., Иванов С.Н., Кливер Е.Н., и др. Путь пациента от острой тромбоэмболии легочной артерии до хронической тромбоэмболической легочной гипертензии: вопросы диагностики и лечения. Терапевтический архив. 2019;91(8):108-14 [Edemskiy AG, Ivanov SN, Kliver EN, et al. Patient's way from acute pulmonary embolism to сhronic thromboembolic pulmonary hypertension: diagnostic and treatment options. Terapevticheskii Arkhiv (Ter. Arkh.). 2019;91(8):108-14 (in Russian)]. doi: 10.26442/00403660.2019.08.000316
  24. Васильцева О.Я., Ворожцова И.Н., Силиванова И.Х., и др. К вопросу о маршрутизации пациентов с тромбоэмболией легочной артерии. Кардиоваскулярная терапия и профилактика. 2016;15(6):72-7 [Vasiltseva OYa, Vorozhtsova IN, Selivanova IKh, et al. An issue of the patients routing in case of pulmonary embolism. Cardiovascular Therapy and Prevention. 2016;15(6):72-7 (in Russian)]. doi: 10.15829/1728-8800-2016-6-72-77
  25. Konstantinides SV. Detection and treatment of chronic thromboembolic pulmonary hypertension: still a lot of homework to do. Hellenic J Cardiol. 2018;59(1):24-5. doi: 10.1016/j.hjc.2018.02.012
  26. Kramm T, Wilkens H, Fuge J, et al. Incidence and characteristics of chronic thromboembolic pulmonary hypertension in Germany. Clin Res Cardiol. 2018;107(7):548-53. doi: 10.1007/s00392-018-1215-5
  27. Condliffe R, Kiely DG, Gibbs JS, et al. Improved outcomes in medically and surgically treated chronic thromboembolic pulmonary hypertension. Am J Respir Crit Care Med. 2008;177(10):1122-27. doi: 10.1164/rccm.20071 2-1841O C
  28. Escribano-Subias P, Blanco I, Lopez-Meseguer M, et al. Survival in pulmonary hypertension in Spain: insights from the Spanish registry. Eur Respir J. 2012;40(3):596-603. doi: 10.1183/09031 936.00101211
  29. López Gude MJ, Pérez de la Sota E, Pérez Vela JL, et al. Pulmonary endarterectomy outputs in chronic thromboembolic pulmonary hypertension. Med Clin (Barc). 2017;149(1):1-8. doi: 10.1016/j.medcli.2016.12.032

Supplementary files

Supplementary Files
Action
1. JATS XML
Download
2. Fig. 1. Multimodal approach to managing chronic thromboembolic pulmonary hypertension.

Download (44KB)
Indexing metadata

Copyright (c) 2024 Consilium Medicum

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
 
 


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies