Coexistence of familial Mediterranean fever and seronegative spondyloarthritis: peculiarities of the course

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Abstract

Familial Mediterranean fever (FMF) is an autosomal recessive disease distributed among populations of Mediterranean origin – Armenians, Sephardi Jews, Arabs, Turks. There are numerous clinical observations regarding combination of FMF, as a classical representative of autoinflammatory diseases, with systemic diseases of connective tissue. Seronegative spondyloarthritis (SpA) are the most interesting disorders from this point of view, as far as sacroiliitis – an essential feature of SpA, may also present as a part of joint syndrome in FMF. The main objective of this clinical study was the investigation of the peculiarities of courses of FMF and SpA in case of their coexistence. We studied 126 patients with FMF, SpA and coexistence of both. According to results, patients with the overlap of FMF with SpA had relatively milder course of disease in comparison with each disease separately. Comparative clinical and instrumental characteristics of FMF-associated disorders had shown that in FMF-SpA overlap the symptoms of both diseases are less severe.

About the authors

Knarik V. Ginosyan

Mkhitar Heratsi Yerevan State Medical University; Geratsi University Clinic

Author for correspondence.
Email: kginosyan@gmail.com
ORCID iD: 0000-0002-8241-8501

зав. каф. ревматологии ЕГМУ, зав. ревматологической службы Университетской больницы «Гераци»

Armenia, Yerevan; Yerevan

Valentina S. Vardanyan

Mkhitar Heratsi Yerevan State Medical University

Email: vvalentina.vardanyan@gmail.com
ORCID iD: 0000-0002-8582-7837

Associate Professor at the Department of Rheumatology

Armenia, Yerevan

Nikolai G. Eghiazaryan

Mkhitar Heratsi Yerevan State Medical University

Email: nikolayarmed@gmail.com

ассистент каф. ревматологии ЕГМУ

Armenia, Yerevan

Zinaida T. Jndoyan

Mkhitar Heratsi Yerevan State Medical University

Email: jndoyanzinaida@rambler.ru
ORCID iD: 0000-0003-0471-8397

Head of department of Propаedeutics of Internal Diseases

Armenia, Yerevan

Irina S. Ghazinyan

Mkhitar Heratsi Yerevan State Medical University

Email: irina.ghazinyan@outlook.com
ORCID iD: 0000-0001-5976-3078

lecturer of department of Propаedeutics of Internal Diseases

Armenia, Yerevan

Aren Yu. Bablumyan

Mkhitar Heratsi Yerevan State Medical University; Geratsi University Clinic

Email: arenbablumyan@yahoo.com
ORCID iD: 0000-0001-8627-5942

professor at Urology Department, Head doctor at “Heratsi” University Clinical Hospital 

Armenia, Yerevan; Yerevan

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