Bone mineral density in women with rheumatoid arthritis: A link between immune and biochemical markers

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Abstract

Aim. To study the association of bone mineral density (BMD) with serum biochemical and immunological markers in postmenopausal women with rheumatoid arthritis (RA).

Materials and methods. The study included 173 women with RA (age 61.0 [56.0; 66.0] years). A survey, dual-energy X-ray absorptiometry to measure the BMD of the lumbar spine (LI–LIV), femoral neck (FN) and total hip (TH), routine blood chemistry, measurement of C-reactive protein (CRP), rheumatoid factor, cyclic citrullinated peptide antibodies (CCPA), parathyroid hormone (PTH), vitamin D3, myostatin, follistatin, interleukin-6 (IL-6), IL-6 receptors, insulin-like growth factor 1, adiponectin, leptin, fibroblast growth factor 23, and tumor necrosis factor SF12 were performed.

Results. PTH (β=-0.22, -0.35 and -0.30 for LI–LIV, FN and TH, respectively), CRP (β=-0.18, 0.23 and -0.22 for LI–LIV, FN and TH, respectively) and leptin (β=0.35, 0.32 and 0.42 for LI–LIV, FN and TH, respectively) were shown a significant association with BMD in all sites of measurement. It was independent of age, body mass index and postmenopause duration. Associations were also found between adiponectin and BMD of LI–LIV and TH (β=-0.36 and -0.28, respectively), CCPA and BMD of FN and TH (β=-0.21, -0.24, respectively) and IL-6 and BMD of FN (β=0.37).

Conclusion. The study of biochemical and immunological markers in women with RA demonstrated that CRP, CCPA, PTH, IL-6, adiponectin, and leptin influenced BMD.

About the authors

Olga V. Dobrovolskaya

Nasonova Research Institute of Rheumatology

Author for correspondence.
Email: olgavdobr@mail.ru
ORCID iD: 0000-0002-2809-0197
Scopus Author ID: 57197823569

кандидат мед. наук, науч. сотрудник лаб. остеопороза

Russian Federation, Moscow

Nikolay V. Demin

Nasonova Research Institute of Rheumatology

Email: deminick@rambler.ru
ORCID iD: 0000-0003-0961-9785
Scopus Author ID: 7006802179

младший научный сотрудник лаб. остеопороза

Russian Federation, Moscow

Maria V. Kozyreva

Nasonova Research Institute of Rheumatology

Email: doginya@yandex.ru
ORCID iD: 0000-0003-0560-3495

младший научный сотрудник лаб. остеопороза

Russian Federation, Moscow

Elena Yu. Samarkina

Nasonova Research Institute of Rheumatology

Email: samarkinale@list.ru
ORCID iD: 0000-0001-7501-9185

младший научный сотрудник лаб. иммунологии и молекулярной биологии ревматических заболеваний

Russian Federation, Moscow

Michail E. Diatroptov

Nasonova Research Institute of Rheumatology

Email: diatrom@inbox.ru
ORCID iD: 0000-0001-6404-0042
Scopus Author ID: 8960133600

доктор биол. наук, ст. науч. сотр. лаб. иммунологии и молекулярной биологии ревматических заболеваний

Russian Federation, Moscow

Natalia V. Toroptsova

Nasonova Research Institute of Rheumatology

Email: torop@irramn.ru
ORCID iD: 0000-0003-4739-4302
Scopus Author ID: 6507457856

доктор мед. наук, зав. лаб. остеопороза

Russian Federation, Moscow

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