Relationship between hypercholesterolemia and osteoarthritis (preliminary results)

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Abstract

Aim. To evaluate the relationship of hypercholesterolemia (HCE) with clinical, instrumental, and laboratory parameters in osteoarthritis (OA) in a multicenter, cross-sectional study.

Materials and methods. The study included 183 patients aged 40–75 years, with a confirmed diagnosis of stage I–III OA (ACR) of the knee joints, who signed an informed consent. The mean age was 55.6±10.7 years (40 to 75), body mass index was 29.3±6.3 kg/m2, and disease duration was 5 [1; 10] years. For each patient, a case record form was filled out, including anthropometric indicators, medical history, clinical examination data, an assessment of knee joint pain according to VAS, WOMAC, KOOS and comorbidities. All patients underwent standard radiography and ultrasound examination of the knee joints and laboratory tests.

Results. HCE was detected in 59% of patients. Depending on its presence or absence, patients were divided into two groups. Patients were comparable in body mass index, waist and hip measurement, and disease duration but differed significantly in age. Individuals with elevated total cholesterol levels had higher VAS pain scores, total WOMAC and its components, an overall assessment of the patient's health, a worse KOOS index, and ultrasound findings (reduced cartilage tissue). HCE patients showed high levels of cholesterol, low-density lipoproteins, triglycerides, STX-II, and COMP (p<0.05). However, after stratification by age, many initial intergroup differences became insignificant, and differences in the WOMAC pain score persisted.

Conclusion. The results of the study confirmed the high prevalence of HCE in OA patients (59%). Patients with OA and increased total cholesterol have more intense pain in the knee joints.

About the authors

Elena A. Taskina

Nasonova Research Institute of Rheumatology

Author for correspondence.
Email: braell@mail.ru
ORCID iD: 0000-0001-8218-3223

кандидат мед. наук, ст. науч. сотр. отд. метаболических заболеваний костей и суставов

Russian Federation, Moscow

Liudmila I. Alekseeva

Nasonova Research Institute of Rheumatology

Email: braell@mail.ru
ORCID iD: 0000-0001-7017-0898

доктор мед. наук, нач. отд. метаболических заболеваний костей и суставов

Russian Federation, Moscow

Natalia G. Kashevarova

Nasonova Research Institute of Rheumatology

Email: braell@mail.ru
ORCID iD: 0000-0001-8732-2720

кандидат мед. наук, науч. сотр. отд. метаболических заболеваний костей и суставов

Russian Federation, Moscow

Ekaterina A. Strebkova

Nasonova Research Institute of Rheumatology

Email: braell@mail.ru
ORCID iD: 0000-0001-8130-5081

кандидат мед. наук, науч. сотр. отд. метаболических заболеваний костей и суставов

Russian Federation, Moscow

Kirill M. Mikhaylov

Nasonova Research Institute of Rheumatology

Email: braell@mail.ru
ORCID iD: 0009-0000-1481-7749

аспирант, врач-ревматолог

Russian Federation, Moscow

Evgeniia P. Sharapova

Nasonova Research Institute of Rheumatology

Email: braell@mail.ru
ORCID iD: 0000-0003-4242-8278

кандидат мед. наук, науч. сотр. отд. метаболических заболеваний костей и суставов

Russian Federation, Moscow

Natalya M. Savushkina

Nasonova Research Institute of Rheumatology

Email: braell@mail.ru
ORCID iD: 0000-0001-8562-6077

кандидат мед. наук, науч. сотр. отд. метаболических заболеваний костей и суставов

Russian Federation, Moscow

Olga G. Alekseeva

Nasonova Research Institute of Rheumatology

Email: braell@mail.ru
ORCID iD: 0000-0003-1852-1798

кандидат мед. наук, врач ультразвуковой диагностики отд-ния функциональной и ультразвуковой диагностики

Russian Federation, Moscow

Tatiana A. Raskina

Kemerovo State Medical University

Email: braell@mail.ru
ORCID iD: 0000-0002-5804-4298

доктор мед. наук, проф., зав. каф. пропедевтики внутренних болезней

Russian Federation, Kemerovo

Julia V. Averkieva

Kemerovo State Medical University

Email: braell@mail.ru
ORCID iD: 0000-0001-8020-4545

кандидат мед. наук, ассистент каф. пропедевтики внутренних болезней

Russian Federation, Kemerovo

Ekaterina V. Usova

Kemerovo State Medical University

Email: braell@mail.ru
ORCID iD: 0000-0002-2988-1652

аспирант каф. пропедевтики внутренних болезней

Russian Federation, Kemerovo

Irina B. Vinogradova

Ulyanovsk Regional Clinical Hospital

Email: braell@mail.ru
ORCID iD: 0000-0001-5052-912X

кандидат мед. наук, зав. ревматологическим центром

Russian Federation, Ulyanovsk

Oksana V. Salnikova

Ulyanovsk Regional Clinical Hospital

Email: braell@mail.ru
ORCID iD: 0000-0003-4068-6337

врач-ревматолог

 

Russian Federation, Ulyanovsk

Aleksandra S. Markelova

Ulyanovsk Regional Clinical Hospital

Email: braell@mail.ru
ORCID iD: 0000-0002-3845-6498

ревматолог

Russian Federation, Ulyanovsk

Aleksander M. Lila

Nasonova Research Institute of Rheumatology

Email: braell@mail.ru
ORCID iD: 0000-0002-6068-3080

чл.-кор. РАН, доктор мед. наук, профессор, директор

Russian Federation, Moscow

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2. Fig. 1. Possible effect of dyslipidemia on osteoarthritis. Adapted from [10].

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