Autoimmune polyendocrine syndrome in adults. Focus on rheumatological aspects of the problem: A review

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Abstract

Autoimmune polyglandular syndromes (APS) are a heterogeneous group of clinical conditions characterized by functional impairment of multiple endocrine glands due to loss of central or peripheral immune tolerance. These syndromes are also often accompanied by autoimmune damage to non-endocrine organs. Taking into account the wide range of components and variants of the disease, APS is usually divided into a rare juvenile type (APS 1) and a more common adult type (APS 2–4). APS type 1 is caused by a monogenic mutation, while APS types 2–4 have a polygenic mode of inheritance. One subtype of adult APS (APS 3D) is characterized by a combination of autoimmune thyroid disease and autoimmune rheumatic disease. This review considers the available literature data on combinations that meet the above criteria. Many studies have noted a significantly higher prevalence of rheumatic diseases in patients with autoimmune thyroid disease compared with the control group. Also, as in a number of rheumatic diseases, a more frequent occurrence of autoimmune thyroiditis, primary hypothyroidism and Graves' disease was noted.

About the authors

Taras S. Panevin

Nasonova Research Institute of Rheumatology; Far Eastern State Medical University

Author for correspondence.
Email: tarasel@list.ru
ORCID iD: 0000-0002-5290-156X
SPIN-code: 7839-3145

канд. мед. наук, науч. сотр. отд. воспалительных заболеваний суставов, врач-эндокринолог ФГБНУ «НИИ ревматологии им. В.А. Насоновой», ассистент каф. факультетской и поликлинической терапии с курсом эндокринологии ФГБОУ ВО ДВГМУ

Russian Federation, Moscow; Khabarovsk

Evgeniy G. Zotkin

Nasonova Research Institute of Rheumatology

Email: ezotkin@mail.ru
ORCID iD: 0000-0002-4579-2836
SPIN-code: 6061-2318

д-р мед. наук, первый зам. дир. ФГБНУ «НИИ ревматологии им. В.А. Насоновой»

Russian Federation, Moscow

Ekaterina A. Troshina

National Medical Research Center for Endocrinology

Email: troshina@inbox.ru
ORCID iD: 0000-0002-8520-8702
SPIN-code: 8821-8990

чл.-кор. РАН, д-р мед. наук, проф., зам. дир. Центра – дир. Института клинической эндокринологии ФГБУ «НМИЦ эндокринологии»

Russian Federation, Moscow

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