Ulcerative colitis and autoimmune uveitis. Case report

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Abstract

The article provides information on the pathogenesis, classification and frequency of ophthalmic extra-intestinal manifestations in patients with inflammatory bowel diseases (IBD). A clinical observation of a patient with autoimmune uveitis and IBD is described, demonstrating the importance of early diagnosis of immuno-inflammatory diseases in the implementation of multidisciplinary management of patients with IBD and extraintestinal manidestations. The use of genetically engineered biological drugs helps to control the course of IBD, ophthalmic manifestations and prevents the development of complications.

About the authors

Anna V. Kagramanova

Loginov Moscow Clinical Scientific Center; Research Institute of Health Organization and Medical Management

Email: asfold@mail.ru
ORCID iD: 0000-0002-3818-6205

канд. мед. наук, ст. науч. сотр. отд-ния воспалительных заболеваний кишечника ГБУЗ «МКНЦ им. А.С. Логинова», вед. специалист отд. по колопроктологии ГБУ НИИОЗММ

Russian Federation, Moscow; Moscow

Vladimir E. Tankovskiy

Helmholtz National Medical Research Center for Eye Diseases

Email: asfold@mail.ru

д-р мед. наук, ст. науч. сотр. отд. патологии сетчатки и зрительного нерва 

Russian Federation, Moscow

Aleksandra N. Demchenko

Loginov Moscow Clinical Scientific Center

Email: asfold@mail.ru

мл. науч. сотр. отд-ния воспалительных заболеваний кишечника

Russian Federation, Moscow

Oleg V. Knyazev

Loginov Moscow Clinical Scientific Center; Ryzikh National Medical Research Centre for Coloproctology

Email: asfold@mail.ru
ORCID iD: 0000-0001-7250-0977

д-р мед. наук, зав. отд-нием воспалительных заболеваний кишечника ГБУЗ «МКНЦ им. А.С. Логинова», проф. научно-образовательного отд. ФГБУ «НМИЦ колопроктологии им. А.Н. Рыжих»

Russian Federation, Moscow; Moscow

Asfold I. Parfenov

Loginov Moscow Clinical Scientific Center

Author for correspondence.
Email: asfold@mail.ru
ORCID iD: 0000-0002-9782-4860

д-р мед. наук, проф., зав. отд. патологии кишечника

Russian Federation, Moscow

References

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  12. Парфенов А.И., Каграманова А.В., Князев О.В. Системные проявления воспалительных заболевания кишечника. Терапевтический архив. 2020;2:4-11 [Parfenov AI, Knyazev OV, Kagramanova AV. Systemic manifestations of inflammatory bowel diseases. Terapevticheskii Arkhiv (Ter. Arkh.). 2020;2:4-11 (in Russian)]. doi: 10.26442/00403660.2020.02.000535
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Supplementary files

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2. Fig. 1. Photo of Patient U. with keratouveitis.

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3. Fig. 2. Patient U’s colonoscopy. Vascular pattern oiled, rebuilt, multiple erosion up to 3-4 mm. Conclusion: ulcerative colitis, total loss, moderate activity (2 points for Schroeder classification).

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4. Fig. 3. Mucous membrane of patient U’s colon. Crypt deformation, decreased number of Goblet cells, basal plasmacytosis. Coloration with hematoxylin and eosin. Magnification up to 120x.

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5. Fig. 4. Vascular pattern rebuilt, focal hyperemia colon mucous (1 points for Schroeder classification).

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6. Fig. 5. Regression of autoimmune uveitis in patient U.

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