Expression of motilin and vasoactive intestinal peptide in diverticular disease of the colon
- Authors: Osadchuk M.A.1, Mironova E.D.1, Krylova I.S.2,3, Gulyaev P.V.1, Akhtyamova R.A.1
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Affiliations:
- Sechenov First Moscow State Medical University (Sechenov University)
- Pavlov First Saint Petersburg State Medical University
- Saint Petersburg State Research Institute of Phthisiopulmonology
- Issue: Vol 96, No 2 (2024)
- Pages: 97-101
- Section: Original articles
- URL: https://journals.rcsi.science/0040-3660/article/view/254704
- DOI: https://doi.org/10.26442/00403660.2024.02.202588
- ID: 254704
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Abstract
Aim. To determine the role of the expression of motilin and vasoactive intestinal peptide (VIP) in diverticular disease of the large intestine (DD).
Materials and methods. Examined 45 patients with DD. The comparison group consisted of 30 practically healthy people. Patients and healthy people were examined according to a single program, including clinical, instrumental (colonoscopy and ultrasound examination of the abdominal cavity and), laboratory (blood glucose, cholesterol, alanine aminotransferase and aspartate aminotransferase) and immunomorphological research methods – use of primary antibodies to motilin (PA5-76926, Invitrogen, USA) and VIP (Ab22736, 1:800, Abcam, UK).
Results. For DD, clinical symptoms are characteristic, mainly fit into the manifestations of functional disorders (constipation, pain along the colon, bloating and increased gas formation). In patients with DD, an increase in body mass index, cholesterol and glucose levels was found. In this category of patients, examinations often verify diabetes mellitus (40%), arterial hypertension (64.4%), cholelithiasis (44.4%), non-alcoholic fatty liver disease (55.5%), gastroesophageal reflux disease (60%). In the group of patients with DD, a significant decrease in the expression of VIP and motilin in the mucous membrane of the large intestine was recorded compared with the group of healthy people (17.31 vs 34.67; p<0.05 and 64.42 vs 76.50; p<0.05 respectively).
Conclusion. The obtained results give grounds to conclude that a decrease in the expression of VIP and motilin in the mucosa of the sigmoid colon is accompanied by hypotension of the colon, which directly and indirectly leads to a violation of the regeneration of the mucosa, which leads to the manifestation of DD.
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##article.viewOnOriginalSite##About the authors
Mikhail A. Osadchuk
Sechenov First Moscow State Medical University (Sechenov University)
Author for correspondence.
Email: osadchuk.mikhail@yandex.ru
ORCID iD: 0000-0003-0485-6802
д-р мед. наук, проф., зав. каф. поликлинической терапии Института клинической медицины им. Н.В. Склифосовского
Russian Federation, MoscowEkaterina D. Mironova
Sechenov First Moscow State Medical University (Sechenov University)
Email: osadchuk.mikhail@yandex.ru
ORCID iD: 0000-0003-3268-2408
канд. мед. наук, ассистент каф. поликлинической терапии Института клинической медицины им. Н.В. Склифосовского
Russian Federation, MoscowIuliia S. Krylova
Pavlov First Saint Petersburg State Medical University; Saint Petersburg State Research Institute of Phthisiopulmonology
Email: osadchuk.mikhail@yandex.ru
ORCID iD: 0000-0002-8698-7904
канд. мед. наук, ассистент каф. патологической анатомии с патологоанатомическим отделением ФГБОУ ВО «Первый СПб ГМУ им. акад. И.П. Павлова», ст. науч. сотр. ФГБУ «СПб НИИФ»
Russian Federation, Saint Petersburg; Saint PetersburgPavel V. Gulyaev
Sechenov First Moscow State Medical University (Sechenov University)
Email: osadchuk.mikhail@yandex.ru
ORCID iD: 0000-0001-7893-7715
д-р мед. наук, доц. каф. поликлинической терапии Института клинической медицины им. Н.В. Склифосовского
Russian Federation, MoscowRegina A. Akhtyamova
Sechenov First Moscow State Medical University (Sechenov University)
Email: osadchuk.mikhail@yandex.ru
ORCID iD: 0000-0002-7748-0845
студентка V курса Института клинической медицины им. Н.В. Склифосовского
Russian Federation, MoscowReferences
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