Liver disease during the pandemic of COVID-19 infection: prediction of the course and tactics of management: A review

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Abstract

The hepatic consequences of SARS-CoV-2 infection are now recognized as an important component of CoronaVIrus Disease 2019 (COVID-19). This aspect is most clinically relevant in patients with pre-existing chronic liver disease (CKD), who are at extremely high risk of severe COVID-19 and death. Risk factors for severe CKD, especially in people with liver cirrhosis and non-alcoholic fatty liver disease, are the direct and indirect cytotoxic effects of coronavirus against the background of systemic inflammation, blood clotting disorders and immune dysfunction. The severe negative impact of the pandemic in the presence of CKD and the difficulties of patient relationships contribute to the progressive increase in the global burden of liver disease on the health system.

About the authors

Igor V. Maev

Yevdokimov Moscow State University of Medicine and Dentistry

Email: osadchuk.mikhail@yandex.ru
ORCID iD: 0000-0001-6114-564X

акад. РАН, д-р мед. наук, проф., проректор по учебной работе

Russian Federation, Moscow

Mikhail A. Osadchuk

Sechenov First Moscow State Medical University (Sechenov University)

Author for correspondence.
Email: osadchuk.mikhail@yandex.ru
ORCID iD: 0000-0003-0485-6802

д-р мед. наук, проф., зав. каф. поликлинической терапии Института клинической медицины им. Н.В. Склифосовского

Russian Federation, Moscow

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