Clinical cases of complicated diverticulitis against the background of severe course COVID-19. Case report

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Abstract

Two clinical cases of perforation of a previously undiagnosed colon diverticulum in patients with coronavirus infection caused by the SARS-CoV-2 virus treated at the Hospital №1 of Nalchik. Both patients were elderly, overweight, had a lot of chronic concomitant diseases. Patients received hormone therapy and were targeted: the first patient twice (tocilizumab on the first day of hospitalization and olokizumab on the 7th day of inpatient treatment). The second patient received levilimab on the 3rd day of his stay in the hospital. A short time after targeting, both patients developed acute diffuse abdominal pain, the patients were transferred to the surgical department and operated on. During the operation, both patients were found to have previously undiagnosed diverticular disease, complicated by diverticular perforation and peritonitis on the background of immunosuppression. Both patients died. Thus, when using targeted therapy for patients with COVID-19, it is necessary to take into account that they may have previously undiagnosed chronic diseases that can cause fatal complications against the background of immunosuppression.

About the authors

Natalia Yu. Pshenichcnaya

Central Research Institute of Epidemiology

Email: asya_marzhoh@mail.ru
ORCID iD: 0000-0003-2570-711X

д-р мед. наук, проф., зав. каф. инфекционных болезней, зам. дир. по клинико-аналитической работе

Russian Federation, Moscow

Zhanna B. Ponezheva

Central Research Institute of Epidemiology

Email: asya_marzhoh@mail.ru
ORCID iD: 0000-0002-6539-4878

д-р мед. наук, проф., зав. клин. отд. инфекционной патологии

Russian Federation, Moscow

Asiyat R. Marzhokhova

Berbekov Kabardino-Balkarian State University

Author for correspondence.
Email: asya_marzhoh@mail.ru
ORCID iD: 0000-0003-4207-5919

канд. мед. наук, доц. каф. инфекционных болезней

Russian Federation, Nalchik

Zaira F. Kharaeva

Berbekov Kabardino-Balkarian State University

Email: asya_marzhoh@mail.ru
ORCID iD: 0000-0003-2302-2491

д-р мед. наук, проф., зав. каф. микробиологии, вирусологии и иммунологии

Russian Federation, Nalchik

Liana E. Balagova

Berbekov Kabardino-Balkarian State University

Email: asya_marzhoh@mail.ru
ORCID iD: 0000-0002-2792-4268

аспирант каф. инфекционных болезней

Russian Federation, Nalchik

Madina Yu. Marzhokhova

Berbekov Kabardino-Balkarian State University

Email: asya_marzhoh@mail.ru
ORCID iD: 0000-0002-5677-5249

д-р мед. наук, проф., зав. каф. инфекционных болезней

Russian Federation, Nalchik

Irina V. Shestakova

Infectious Clinical Hospital №2

Email: asya_marzhoh@mail.ru
ORCID iD: 0000-0002-8516-9088

д-р мед. наук, проф., врач-инфекционист

Russian Federation, Moscow

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2. Fig. 1. Radiograph of chest organs patient Zh. from 11.11.2021.

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3. Fig. 2. Radiograph of the abdominal organs of patient M.

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