Diagnostics and treatment of intraductal papillary mucinous pancreas neoplasm

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Abstract

A clinical case of a 71-year-old patient with intraductal papillary mucinous neoplasia (IPMN) is presented. The diagnosis was established using endoscopic retrograde cholangiopancreatography, magnetic resonance imaging, computed tomography. Asymptomatic course, absence of pain syndrome, obstruction, exocrine and endocrine pancreatic failure, relatively satisfactory general health, but the presence of structural changes: an increase cyst in the head of the pancreas measuring 27×23 mm, expansion of the main pancreatic duct up to 13 mm raised doubts about the choice of treatment tactics, the need for surgical intervention. To exclude the risk of malignancy and the choice of treatment tactics, a fine-needle aspiration biopsy was performed, a cytological examination of the material, an expert opinion determined the scope of the surgical intervention. IPMN is a rather rare tumor of the pancreas. For a long time, IPMN flow “under the guise” of chronic pancreatitis. Depending on the type of degree of dysplasia and invasiveness of IPMN, the tactics of treatment and the volume of surgical intervention are determined. High-tech methods provide high information content in the diagnosis of IPMN. But only a morphological study allows you to determine the tactics of treatment.

About the authors

Igor E. Khatkov

Loginov Moscow Clinical Scientific Center

Email: o_solovjova@inbox.ru
ORCID iD: 0000-0002-4088-8118

канд. мед. наук, доц., доц. каф. внутренних болезней, клинической фармакологии и нефрологии ФГБОУ ВО «СЗГМУ им. И.И. Мечникова»

Russian Federation, Moscow

Elena G. Poroshina

Mechnikov North-Western State Medical University

Email: o_solovjova@inbox.ru
ORCID iD: 0009-0003-1649-309X

канд. мед. наук, доц., доц. каф. внутренних болезней, клинической фармакологии и нефрологии ФГБОУ ВО «СЗГМУ им. И.И. Мечникова»

Russian Federation, Saint Petersburg

Olga I. Solovyeva

Mechnikov North-Western State Medical University

Author for correspondence.
Email: o_solovjova@inbox.ru
ORCID iD: 0000-0003-0037-7855

канд. мед. наук, доц., доц. каф. внутренних болезней, клинической фармакологии и нефрологии ФГБОУ ВО «СЗГМУ им. И.И. Мечникова»

Russian Federation, Saint Petersburg

Tatyana P. Tokareva

Mechnikov North-Western State Medical University

Email: o_solovjova@inbox.ru
ORCID iD: 0009-0009-4408-2312

зав. отд-нием эндокринологии и нефрологии Клиники им. Петра Великого ФГБОУ ВО «СЗГМУ им. И.И. Мечникова»

Russian Federation, Saint Petersburg

Sergey L. Vorobyev

National Center for Clinical Morphological Diagnostics

Email: o_solovjova@inbox.ru
ORCID iD: 0000-0002-7817-9069

канд. мед. наук, дир. ООО «Национальный центр клинической морфологической диагностики»

Russian Federation, Saint Petersburg

Natalia V. Bakulina

Mechnikov North-Western State Medical University

Email: o_solovjova@inbox.ru
ORCID iD: 0000-0003-4075-4096

д-р мед. наук, проф., зав. каф. внутренних болезней, клинической фармакологии и нефрологии, проректор по науке и инновационной деятельности ФГБОУ ВО «СЗГМУ им. И.И. Мечникова»

Russian Federation, Saint Petersburg

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Supplementary files

Supplementary Files
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1. JATS XML
2. Fig. 1. Types of intraductal papillary mucinous tumor: a – intestinal; b – pancreatobiliary; c – gastric.

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3. Fig. 2. Medical history.

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4. Fig. 3. a – cytological examination of the specimen (endoscopic ultrasound guided fine needle biopsy – EUS-FNB): abundance of mucin, single papillary complexes of mucin-producing epithelium, low grade; MGG stain, ×200; b – cell block fragment of EUS-FNB specimen with papillary structure neoplasia lined with mucin-producing epithelium with proliferation signs, low grade; HE and alcian blue stain, ×200.

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5. Fig. 4. Log of glucose levels for 30.10.2022.

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