Subclinical markers of liver damage in patients with arterial hypertension and obesity

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Abstract

Aim. To investigate the possibility of preclinical detection of liver damage in patients with hypertension and obesity.

Materials and methods. The study included 168 patients with hypertension aged 30 to 60 years. All patients underwent general clinical and laboratory-instrumental examination, including ultrasound of the abdominal organs with Doppler assessment of blood flow and determination of markers such as ALT, AST, TG, lipid profile indicators at inclusion, after a month, three months and nine months.

Results. Depending on the presence of obesity, all patients with hypertension were divided into two groups. Obese patients had a statistically significant increase in office blood pressure, FSI, the ratio of TG and LDL-C to HDL-C, a more significant higher average levels of glucose, TG and ALT levels, as well as impaired hepatic blood flow according to ultrasound.

Conclusion. Indicators of FSI, ALT/AST ratio, ratio of TG and LDL-С to HDL-C as well as assessment of hepatic blood flow indicators can be used for early diagnosis of nonalcoholic fatty liver disease, as they predict liver steatosis.

About the authors

Irina A. Sadulaeva

Yevdokimov Moscow State University of Medicine and Dentistry

Author for correspondence.
Email: sadvas@mail.ru
ORCID iD: 0000-0002-9278-2008

канд. мед. наук, проф. каф. клинической функциональной диагностики

Russian Federation, Moscow

Elena N. Yushchuk

Yevdokimov Moscow State University of Medicine and Dentistry

Email: sadvas@mail.ru
ORCID iD: 0000-0003-0065-5624

д-р мед. наук, проф., зав. каф. клинической функциональной диагностики

Russian Federation, Moscow

Liliia F. Khalikova

Yevdokimov Moscow State University of Medicine and Dentistry

Email: sadvas@mail.ru
ORCID iD: 0000-0002-3040-4706

аспирант каф. клинической функциональной диагностики

Russian Federation, Moscow

Olga V. Krikunova

Yevdokimov Moscow State University of Medicine and Dentistry

Email: sadvas@mail.ru
ORCID iD: 0000-0001-9488-4772

канд. мед. наук, доц. каф. клинической функциональной диагностики

Russian Federation, Moscow

Olga S. Trofimenko

Yevdokimov Moscow State University of Medicine and Dentistry

Email: sadvas@mail.ru
ORCID iD: 0000-0002-5648-672X

канд. мед. наук, доц., зав. учебной частью каф. клинической функциональной диагностики

Russian Federation, Moscow

Elizaveta G. Medvedeva

Yevdokimov Moscow State University of Medicine and Dentistry

Email: sadvas@mail.ru
ORCID iD: 0000-0002-5011-5346

ассистент каф. клинической функциональной диагностики

Russian Federation, Moscow

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Supplementary files

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2. Fig. 1. Framingham Steatosis Index Values for all patients.

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3. Fig. 2. Alanine aminotransferase/ Aspartate aminotransferase values.

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4. Fig. 3. Triglycerides to high density lipoprotein cholesterol ratio.

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5. Fig. 4. Framingham Steatosis Index values in patients with Steatosis Presence/Absence

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