Email this article Prevalence, age and gender features of chronic kidney disease in patients with diabetes mellitus
- Authors: Murkamilov I.T.1,2, Aitbaev K.A.3, Fomin V.V.4
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Affiliations:
- Akhunbaev Kyrgyz State Medical Academy
- Yeltsin Kyrgyz-Russian Slavic University
- Research Institute of Molecular Biology and Medicine
- Sechenov First Moscow State Medical University (Sechenov University)
- Issue: Vol 95, No 6 (2023)
- Pages: 481-486
- Section: Original articles
- URL: https://journals.rcsi.science/0040-3660/article/view/133108
- DOI: https://doi.org/10.26442/00403660.2023.06.202242
- ID: 133108
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Abstract
Aim. To study the prevalence, age and gender characteristics of chronic kidney disease (CKD) in patients with diabetes mellitus (DM).
Materials and methods. In a case-control study, clinical and laboratory data were analyzed in 683 patients with DM (4.6% of patients with type 1 DM and 95.4% with type 2 DM) and kidney damage. The indicators of anthropometry, hemodynamics and biochemistry were studied. The glomerular filtration rate (GFR) was calculated using the CKD-EPI formula.
Results. The proportion of middle-aged and elderly patients with CKD was the most numerous, amounting to 39 and 38%, respectively. At the same time, anemia was more common in young people, and hypercholesterolemia (35.0%), proteinuria (47.5%) and signs of renal failure (45.0%) – in middle-aged patients with CKD. 47.0% study participants had C1 and C2 categories of changes in renal function. Mean levels of systolic blood pressure (BP), the prevalence of proteinuria were statistically significantly higher in women. When evaluating the correlations, we found statistically significant relationships between the calculated GFR and the level of body mass index, systolic BP, venous blood glucose and Hb in the subgroup of men. Among females, a significant relationship between the calculated GFR value was revealed with indicators of systolic and diastolic BP, venous blood glucose and Hb concentration.
Conclusion. Our data indicate the existence of differences in the prevalence of CKD and associated risk factors for the progression of renal failure, depending on gender differences and living conditions of patients. In urban residents, CKD was most often associated with arterial hypertension and renal failure, while overweight, obesity, and proteinuria were significantly more common in rural areas. The incidence of proteinuria and mean levels of systolic BP were significantly higher in females. Further study of the issue under discussion seems promising from the standpoint of a personalized approach and the search for a new preventive strategy to combat both end-stage renal failure and its complications.
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##article.viewOnOriginalSite##About the authors
Ilkhom T. Murkamilov
Akhunbaev Kyrgyz State Medical Academy; Yeltsin Kyrgyz-Russian Slavic University
Author for correspondence.
Email: murkamilov.i@mail.ru
ORCID iD: 0000-0001-8513-9279
д-р мед. наук, доц. каф. факультетской терапии КГМА им. И.К. Ахунбаева, ст. преподаватель ГОУ ВПО КРСУ, председатель правления Общества специалистов по хронической болезни почек Кыргызстана
Kyrgyzstan, Bishkek; BishkekKubanych A. Aitbaev
Research Institute of Molecular Biology and Medicine
Email: murkamilov.i@mail.ru
ORCID iD: 0000-0003-4973-039X
д-р мед. наук, проф., зав. лаб. патологической физиологии НИИ молекулярной биологии и медицины, член правления Общества специалистов по хронической болезни почек Кыргызстана
Kyrgyzstan, BishkekVictor V. Fomin
Sechenov First Moscow State Medical University (Sechenov University)
Email: murkamilov.i@mail.ru
ORCID iD: 0000-0002-2682-4417
чл.-кор. РАН, д-р мед. наук., проф., зав. каф. факультетской терапии №1 Института клинической медицины им. Н.В. Склифосовского, проректор по инновационной и клинической деятельности ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова» (Сеченовский Университет)
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