Rheumatoid factor: study history and concept evolution

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Abstract

Rheumatoid factor became the first laboratory marker of rheumatoid arthritis and one of the first serological markers used to recognize the major autoimmune diseases. Details of the discovery with special regard to contribution of E. Waaler and H. Rose are presented in this historical review. Same assays used to exam the rheumatoid factor, its frequency and modern view on diagnostic significance in different diseases are described in this article.

About the authors

Sergei V. Guliaev

Sechenov First Moscow State Medical University (Sechenov University)

Author for correspondence.
Email: guldoc@mail.ru
ORCID iD: 0000-0001-6138-4333

кандидат медицинских наук, доцент кафедры внутренних, профессиональных болезней и ревматологии

Russian Federation, Moscow

Leonid A. Strizhakov

Sechenov First Moscow State Medical University (Sechenov University)

Email: guldoc@mail.ru
ORCID iD: 0000-0002-2291-6453

доктор медицинских наук, проф. кафедры внутренних, профессиональных болезней и ревматологии

Russian Federation, Moscow

Sergey V. Moiseev

Sechenov First Moscow State Medical University (Sechenov University)

Email: guldoc@mail.ru
ORCID iD: 0000-0002-7232-4640

член-кор. РАН, доктор медицинских наук, заведующий кафедрой внутренних профессиональных болезней и ревматологии, директор клиники имени Е.М. Тареева

Russian Federation, Moscow

References

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