AL amyloidosis mimicking IgG4-related disease: case report

Cover Page

Cite item

Full Text

Abstract

The article describes a unique clinical case of AL amyloidosis mimicking IgG4-related disease. Plasma cell dyscrasias can mimic clinical and laboratory manifestations of rheumatic diseases, which can lead to a delay in diagnosis and inappropriate therapy.

About the authors

Bogdan D. Chaltsev

Nasonova Research Institute of Rheumatology

Author for correspondence.
Email: bodya92@inbox.ru
ORCID iD: 0000-0003-4188-3578

кандидат медицинских наук, младший научный сотрудник лаборатории редких ревматических заболеваний и болезни Шегрена

Russian Federation, Moscow

Anna V. Torgashina

Nasonova Research Institute of Rheumatology

Email: bodya92@inbox.ru
ORCID iD: 0000-0001-8099-2107

кандидат медицинских наук, зав. лаборатории редких ревматических заболеваний и болезни Шегрена

Russian Federation, Moscow

References

  1. Сокол Е.В. IgG4-связанное заболевание: что мы знаем 20 лет спустя. Терапевтический архив. 2020;92(5):104-9 [Sokol EV. IgG4-related disease: what do we know after 20 years. Terapevticheskii Arkhiv (Ter. Arkh.). 2020;92(5):104-9 (in Russian)]. doi: 10.26442/00403660.2020.05.000632
  2. Wallace ZS, Deshpande V, Mattoo H, et al. IgG4-Related Disease: Clinical and Laboratory Features in One Hundred Twenty-Five Patients. Arthritis Rheumatol. 2015;67(9):2466-75. doi: 10.1002/art.39205
  3. Carruthers MN, Khosroshahi A, Augustin T, et al. The diagnostic utility of serum IgG4 concentrations in IgG4-related disease. Ann Rheum Dis. 2015;74(1):14-8. doi: 10.1136/annrheumdis-2013-204907
  4. Umehara H, Okazaki K, Kawa S, et al. The 2020 revised comprehensive diagnostic (RCD) criteria for IgG4-RD. Mod Rheumatol. 2021;31(3):529-33. doi: 10.1080/14397595.2020.1859710
  5. Wallace ZS, Naden RP, Chari S, et al. The 2019 American College of Rheumatology/European League Against Rheumatism Classification Criteria for IgG4-Related Disease. Arthritis Rheumatol. 2020;72(1):7-19. doi: 10.1002/art.41120
  6. Chen LYC, Mattman A, Seidman MA, Carruthers MN. IgG4-related disease: what a hematologist needs to know. Haematologica. 2019;104(3):444-55. doi: 10.3324/haematol.2018.205526
  7. Сокол Е.В., Черкасова М.В., Торгашина А.В. Диагностическая ценность IgG4 сыворотки крови при IgG4-связанном заболевании: так ли она велика? Современная ревматология. 2019;13(1):52-7 [Sokol EV, Cherkasova MV, Torgashina AV. The diagnostic value of serum IgG4 for the diagnosis of IgG4-related disease: and is that so great? Modern Rheumatology Journal. 2019;13(1):52-7 (in Russian)]. doi: 10.14412/1996-7012-2019-1-52-57
  8. Васильев В.И., Пальшина С.Г., Павловская А.И., и др. Идиопатическая мультицентрическая болезнь Кастлемана. Терапевтический архив. 2020;92(5):78-84 [Vasilyev VI, Palshina SG, Pavlovskaya AI, et al. Idiopathic multicentric Castleman’s disease. Terapevticheskii Arkhiv (Ter. Arkh.). 2020;92(5):78-84 (in Russian)]. doi: 10.26442/00403660.2020.05.000440
  9. Васильев В.И., Сокол Е.В., Кокосадзе Н.В., и др. Дифференциальная диагностика болезни Эрдгейма–Честера и заболеваний, связанных с IgG4. Терапевтический архив. 2016;88(5):70-6 [Vasiliev VI, Sokol EV, Kokosadze NV, et al. The differential diagnosis of Erdheim–Chester disease and IgG4-related diseases. Terapevticheskii Arkhiv (Ter. Arkh.). 2016;88(5):70-6 (in Russian)]. doi: 10.17116/terarkh201688570-76
  10. Zheng M, Zhou P, Zheng K, et al. A special subtype of POEMS syndrome: IgG4 subtype. Am J Transl Res. 2016;8(2):588-96.
  11. Gauiran DTV, Marcon KM, DeMarco ML, et al. IgG4 plasma cell myeloma without clinical evidence of IgG4-related disease: a report of two cases. Hematology. 2020;25(1):335-40. doi: 10.1080/16078454.2020.1815130
  12. Geyer JT, Niesvizky R, Jayabalan DS, et al. IgG4 plasma cell myeloma: new insights into the pathogenesis of IgG4-related disease. Mod Pathol. 2014;27(3):375-81. doi: 10.1038/modpathol.2013.159
  13. Yu KH, Chan TM, Tsai PH, et al. Diagnostic Performance of Serum IgG4 Levels in Patients With IgG4-Related Disease. Medicine (Baltimore). 2015;94(41):e1707. doi: 10.1097/MD.0000000000001707
  14. Inoue D, Yoshida K, Yoneda N, et al. IgG4-related disease: dataset of 235 consecutive patients. Medicine (Baltimore). 2015;94(15):e680. doi: 10.1097/MD.0000000000000680
  15. Karim F, Clahsen-van Groningen M, van Laar JA. AA Amyloidosis and IgG4-Related Disease. N Engl J Med. 2017;376(6):599-600. doi: 10.1056/NEJMc1614275
  16. Wisniowski-Yáñez A, Zavala-García G, Hernández-Molina G, et al. Amyloid A amyloidosis secondary to immunoglobulin G4-related disease. Rheumatology (Oxford). 2021;60(3):e97-8. doi: 10.1093/rheumatology/keaa467
  17. Martín-Nares E, Saavedra-González V, Fagundo-Sierra R, et al. Serum immunoglobulin free light chains and their association with clinical phenotypes, serology and activity in patients with IgG4-related disease [published correction appears in Sci Rep. 2021 Jun 1;11(1):11959]. Sci Rep. 2021;11(1):1832. doi: 10.1038/s41598-021-81321-5
  18. Kyrtsonis MC, Vassilakopoulos TP, Kafasi N, et al. Prognostic value of serum free light chain ratio at diagnosis in multiple myeloma. Br J Haematol. 2007;137(3):240-3. doi: 10.1111/j.1365-2141.2007.06561.x
  19. Dispenzieri A, Lacy MQ, Katzmann JA, et al. Absolute values of immunoglobulin free light chains are prognostic in patients with primary systemic amyloidosis undergoing peripheral blood stem cell transplantation. Blood. 2006;107(8):3378-83. doi: 10.1182/blood-2005-07-2922
  20. Papadea C, Reimer CB, Check IJ. IgG subclass distribution in patients with multiple myeloma or with monoclonal gammopathy of undetermined significance. Ann Clin Lab Sci. 1989;19(1):27-37.

Supplementary files

Supplementary Files
Action
1. JATS XML

Copyright (c) 2023 Consilium Medicum

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
 
 


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies