The structure of post/long COVID fatigue syndrome. Prospects for correction
- Authors: Kuznetsova P.I.1, Tanashyan M.M.1, Raskurazhev A.A.1, Zaslavskaya K.I.2
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Affiliations:
- Scientific Center of Neurology
- Ogarev National Research Mordovian State University
- Issue: Vol 95, No 5 (2023)
- Pages: 418-424
- Section: Original articles
- URL: https://journals.rcsi.science/0040-3660/article/view/132959
- DOI: https://doi.org/10.26442/00403660.2023.05.202224
- ID: 132959
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Abstract
Aim. To study the features of post-COVID asthenic syndrome and evaluate the effectiveness of the drug containing the succinic acid complex with trimethylhydrazinium in its treatment.
Materials and methods. A prospective, multicenter, comparative, randomized, double-blind, placebo-controlled study of the efficacy of sequential therapy with BRAINMAX® included 160 patients with a history of coronavirus infection within 12 to 16 weeks (not more than 12 months). The study was conducted at 6 healthcare centers in different regions of the Russian Federation. Testing was performed on the following scores: VAS for headache score, MFI-20 asthenia score, PSQI test, FAS-10 fatigue score, DHI dizziness score, MoCA cognitive impairment score, Beck anxiety score, vegetative index of Kerdo.
Results. PSQI questionnaire showed significant improvement in sleep quality in the study group: by -2.5 points [-4; -1] (p<0.001); there was a more pronounced significant decrease in the MFI-20 score of -19.5 points [-27; -11] (p<0.001); a significant decrease in the FAS-10 fatigue score by -9 [-13.5; -4] points (p<0.001); DHI dizziness score showed a decrease by -6 [-12; 0] points in the BRAINMAX® group (p=0.001); the score of Beck anxiety and depression scale decreased by -5 [-11; -2] points (p<0.001). Multiple linear regression data showed a significant increase of 0.56 (p=0.02) in the MoCA score.
Conclusion. Our study convincingly showed the effectiveness of therapy with BRAINMAX® in a wide range of symptoms in patients with the post-COVID syndrome.
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##article.viewOnOriginalSite##About the authors
Polina I. Kuznetsova
Scientific Center of Neurology
Author for correspondence.
Email: angioneurology0@gmail.com
ORCID iD: 0000-0002-4626-6520
кандидат медицинских наук, научный сотр., врач-невролог 1-го неврологического отделения
Russian Federation, MoscowMarine M. Tanashyan
Scientific Center of Neurology
Email: angioneurology0@gmail.com
ORCID iD: 0000-0002-5883-8119
чл.-кор. РАН, доктор медицинских наук, профессор, зам. директора по научной работе, рук. 1-го неврологического отделения
Anton A. Raskurazhev
Scientific Center of Neurology
Email: angioneurology0@gmail.com
ORCID iD: 0000-0003-0522-767X
кандидат медицинских наук, старший научный сотр., врач-невролог 1-го неврологического отделения
Kira Ia. Zaslavskaya
Ogarev National Research Mordovian State University
Email: angioneurology0@gmail.com
ORCID iD: 0000-0002-7348-9412
ассистент кафедры биологической и фармацевтической химии с курсом организации и управления фармацией Медицинского института
Russian Federation, SaranskReferences
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