Email this article Endoscopic and morphometric analysis of the reduction of acute inflammatory process in the gastric mucosa after therapy with Regasthym Gastro
- Authors: Baryshnikova N.V.1,2,3, Uspenskiy Y.P.1,2, Fominykh Y.A.1,2, Petlenko S.V.4, Zaplutanov V.A.5, Apryatina V.A.6, Krasnov A.A.7
-
Affiliations:
- Saint Petersburg State Pediatric Medical University
- Pavlov First Saint Petersburg State Medical University
- Institute of Experimental Medicine
- Golikov Research Clinical Center of Toxicology
- Saint Petersburg Institute of Bioregulation and Gerontology
- Saint Petersburg State University
- Herzen Russian State Pedagogical University
- Issue: Vol 95, No 4 (2023)
- Pages: 322-326
- Section: Original articles
- URL: https://journals.rcsi.science/0040-3660/article/view/132923
- DOI: https://doi.org/10.26442/00403660.2023.04.202147
- ID: 132923
Cite item
Full Text
Abstract
Aim. To analyze the anti-inflammatory efficacy of Regasthym Gastro (alpha-glutamyl-tryptophan) in the treatment of patients with chronic atrophic gastritis according to endoscopic and morphometric studies.
Materials and methods. As part of a double-blind placebo-controlled study, the results of gastroscopy and histological (morphometric) studies were retrospective analyzed in 80 patients diagnosed with chronic atrophic gastritis associated with Helicobacter pylori in exacerbation: 43 patients took Regasthym Gastro, 37 patients – placebo. The conclusions of the gastroscopy were structured in the form of a standardized scale, which included an assessment of criteria in points (from 0 to 3): thickness of folds, hyperemia, edema of the gastric mucosa, the signs of atrophy, metaplasia; the severity of the erosive process. The sum of points according to all criteria was used to assess the dynamics of the inflammatory process: positive dynamics; lack of dynamics; the pathological process is progressing. The results of the endoscopic examination were compared with morphometry data (the number of inflammation pool cells per 1 mm2 of gastric mucosa). Statistical processing of the results was carried out using the Statistica 12 application software package.
Results. According to the gastroscopy, before therapy, hyperemia of the gastric mucosa was present in 82.5%, edema – in 53.8%, erosion – in 17.5%, signs of metaplasia – in 12.5% of patients. After therapy with the investigated drug a statistically significant decrease in the severity of edema of the gastric mucosa (p=0.008), the total set of signs of acute inflammatory process (p=0.006), a decrease in the proportion of outcomes with negative dynamics of the inflammatory process (p=0.038) was revealed. Statistically significant (p<0.05) correlations were found between gastroscopy data of inflammation and the number of neutrophil, eosinophil granulocytes, macrophages and lymphocytes per 1 mm2.
Conclusion. Regasthym Gastro contributes to a significant decrease in the severity of the inflammatory process according to the evaluation of the results of gastroscopy and morphometry. It is possible to recommend the inclusion of this drug in the complex therapy of chronic gastritis to increase the effectiveness and reduce the risks of progression of inflammation.
Full Text
##article.viewOnOriginalSite##About the authors
Natalia V. Baryshnikova
Saint Petersburg State Pediatric Medical University; Pavlov First Saint Petersburg State Medical University; Institute of Experimental Medicine
Email: uspenskiy65@mail.ru
ORCID iD: 0000-0001-7429-0336
канд. мед. наук, доц., мл. науч. сотр. лаб. медико-социальных проблем педиатрии ФГБОУ ВО СПбГПМУ, доц. каф. внутренних болезней стоматологического фак-та ФГБОУ ВО «ПСПбГМУ им. акад. И.П. Павлова», науч. сотр. лаб. молекулярной микробиологии ФГБНУ ИЭМ
Russian Federation, Saint Petersburg; Saint Petersburg; Saint PetersburgYury P. Uspenskiy
Saint Petersburg State Pediatric Medical University; Pavlov First Saint Petersburg State Medical University
Author for correspondence.
Email: uspenskiy65@mail.ru
ORCID iD: 0000-0001-6434-1267
д-р мед. наук, проф., зав. каф. факультетской терапии им. В.А. Вальдмана ФГБОУ ВО СПбГПМУ, проф. каф. внутренних болезней стоматологического фак-та ФГБОУ ВО «ПСПбГМУ им. акад. И.П. Павлова»
Russian Federation, Saint Petersburg; Saint PetersburgYulia A. Fominykh
Saint Petersburg State Pediatric Medical University; Pavlov First Saint Petersburg State Medical University
Email: uspenskiy65@mail.ru
ORCID iD: 0000-0002-2436-3813
д-р мед. наук, проф. каф. факультетской терапии им. В.А. Вальдмана ФГБОУ ВО СПбГПМУ, доц. каф. внутренних болезней стоматологического фак-та ФГБОУ ВО «ПСПбГМУ им. акад. И.П. Павлова»
Russian Federation, Saint Petersburg; Saint PetersburgSergey V. Petlenko
Golikov Research Clinical Center of Toxicology
Email: uspenskiy65@mail.ru
ORCID iD: 0000-0002-2752-4598
д-р мед. наук, вед. науч. сотр. ФГБУ «НКЦТ им. акад. С.Н. Голикова»
Russian Federation, Saint PetersburgVasiliy A. Zaplutanov
Saint Petersburg Institute of Bioregulation and Gerontology
Email: uspenskiy65@mail.ru
ORCID iD: 0000-0001-5294-6533
науч. сотр. лаб. фармакологии пептидов АННО ВО НИЦ СПбИБГ
Russian Federation, Saint PetersburgVera A. Apryatina
Saint Petersburg State University
Email: uspenskiy65@mail.ru
ORCID iD: 0000-0002-9819-6835
канд. мед. наук, ст. науч. сотр. лаб. нейробиологии и молекулярной фармакологии Института трансляционной биомедицины ФГБОУ ВО СПбГУ
Russian Federation, Saint PetersburgAlexey A. Krasnov
Herzen Russian State Pedagogical University
Email: uspenskiy65@mail.ru
ORCID iD: 0000-0002-8732-6390
д-р мед. наук, доц. каф. медико-валеологических дисциплин
Russian Federation, Saint PetersburgReferences
- Ивашкин В.Т., Лапина Т.Л. Хронический гастрит: современные представления, принципы диагностики и лечения. РМЖ. 2001;2:54 [Ivashkin VT, Lapina TL. Chronic gastritis: modern concepts, principles of diagnosis and treatment. RMZh. 2001;2:54 (in Russian)].
- Красильникова П.Л., Филимонов С.Н., Плотникова Е.Ю. Роль этиологических факторов в развитии хронического гастрита и рака желудка у жителей крупного промышленного центра Западной Сибири. Медицина в Кузбассе. 2019;18(2):70-5 [Krasilnikova PL, Filimonov SN, Plotnikova EYu. Role of etiological factors in the development of chronic gastritis and stomach cancer in residents of a large industrial center of Western Siberia. Medicine in Kuzbass. 2019;18(2):70-5 (in Russian)].
- Минушкин О.Н. Хронический гастрит: представления, диагностика, лечебные подходы. Медицинский совет. 2007;3:71-6 [Minushkin ON. Chronic gastritis: representations, diagnostics, therapeutic approaches. Meditsinskii sovet. 2007;3:71-6 (in Russian)].
- Циммерман Я.С. Стойкие заблуждения современной гастроэнтерологии. Клиническая фармакология и терапия. 2016;25(5):5-13 [Zimmerman YaS. Persistent misconceptions of modern gastroenterology. Klinicheskaya pharmakologia i therapia. 2016;25(5):5-13 (in Russian)].
- Голофеевский В.Ю. Размышления о природе и общих закономерностях морфогенеза хронического гастрита. Экспериментальная и клиническая гастроэнтерология. 2017;148(12):76-81 [Golofeevskii VYu. Reflections about the nature and general pattern of morphogenesis a chronic gastritis. Eksperimental’naya i Klinicheskaya Gastroenterologiya. 2017;148(12):76-81 (in Russian)].
- Короткевич А.Г., Аксенов П.В. К эндоскопической классификации хронических гастритов. Экспериментальная и клиническая гастроэнтерология. 2018;152(4):53-9 [Korotkevich AG, Aksenov PV. To endoscopic classification of chronic gastritises. Experimental and Clinical Gastroenterology. 2018;152(4):53-9 (in Russian)].
- Correa P. Chronic gastritis: a clinico-pathological classification. Am J Gastroenterol. 1988;83(5):504-9.
- Correa P. Gastric cancer: overview. Gastroenterol Clin North Am. 2013;42(2):211-7. doi: 10.1016/j.gtc.2013.01.002
- Вялов С.С. Хронический гастрит: клинические варианты и лечение. Consilium Medicum. 2017;19(8):103-9 [Vialov SS. Chronic gastritis: clinical variants and treatment. Consilium Medicum. 2017;19(8):103-9 (in Russian)]. doi: 10.26442/2075-1753_19.8.103-109
- Кононов А.В. Helicobacter pylori и воспаление: иллюзия решенных проблем. Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2003;3(прил. 19):39-45 [Kononov AV. Helicobacter pylori and inflammation: the illusion of solved problems. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2003;3(Suppl. 19):39-45 (in Russian)].
- Ливзан М.А., Кононов А.В., Мозговой С.И. Постэрадикационный период хронического гастрита, ассоциированного с инфекцией Helicobacter pylori. Consilium Medicum. 2008;10(8):15-20 [Livzan MA, Kononov AV, Mozgovoy SI. Post-eradication period of chronic gastritis associated with Helicobacter pylori infection. Consilium Medicum. 2008;10(8):15-20 (in Russian)].
- Ливзан М.А., Гаус О.В., Мозговой С.И. Хронический атрофический гастрит: тактика курации пациента. РМЖ. Медицинское обозрение. 2021;5(6):427-32 [Livzan MA, Gaus OV, Mozgovoi SI. Chronic atrophic gastritis: patient management. Russian Medical Inquiry. 2021;5(6):427-32 (in Russian)]. doi: 10.32364/2587-6821-2021-5-6-427-432
- Павлович И.М., Голофеевский В.Ю., Калиновский В.П. Хронический атрофический гастрит: особенности морфологической структуры и пепсинобразующей функции. Вопросы онкологии. 2006;52(3):353-6 [Pavlovich IM, Golofeevskii VIu, Kalinovskii VP. Chronic atrophic gastritis: morphological features and pepsin formation function. Voprosy Onkologii. 2006;52(3):353-6 (in Russian)].
- Shatila M, Thomas AS. Current and Future Perspectives in the Diagnosis and Management of Helicobacter pylori Infection. J Clin Med. 2022;11(17):5086. doi: 10.3390/jcm11175086
- Ito M, Tanaka S, Kamada T, et al. Causal role of Helicobacter pylori infection and eradication therapy in gastric carcinogenesis. World J Gastroenterol. 2006;12(1):10-6. doi: 10.3748/wjg.v12.i1.10
- Wei Y, Jiang C, Han Y, et al. Characteristics and background mucosa status of early gastric cancer after Helicobacter pylori eradication: A narrative review. Medicine (Baltimore). 2022;101(48):e31968. doi: 10.1097/MD.0000000000031968
- Барышникова Н.В., Успенский Ю.П., Калинина Е.Ю., и др. Эффективность альфа-глутамил-триптофана в купировании воспаления у больных хроническим атрофическим гастритом, ассоциированным с Helicobacter pylori. Доказательная гастроэнтерология. 2022;11(4):15-21 [Baryshnikova NV, Uspenskiy YuP, Kalinina EYu, et al. Alpha-glutamyl-tryptophan decreases inflammation in mucosa of patients with Helicobacter pylori associated atrophic gastritis. Russian Journal of Evidence-Based Gastroenterology. 2022;11(4):15-21 (in Russian)]. doi: 10.17116/dokgastro20221104115.
Supplementary files
