Endoscopic and morphometric analysis of the reduction of acute inflammatory process in the gastric mucosa after therapy with Regasthym Gastro
- Authors: Baryshnikova N.V.1,2,3, Uspenskiy Y.P.1,2, Fominykh Y.A.1,2, Petlenko S.V.4, Zaplutanov V.A.5, Apryatina V.A.6, Krasnov A.A.7
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Affiliations:
- Saint Petersburg State Pediatric Medical University
- Pavlov First Saint Petersburg State Medical University
- Institute of Experimental Medicine
- Golikov Research Clinical Center of Toxicology
- Saint Petersburg Institute of Bioregulation and Gerontology
- Saint Petersburg State University
- Herzen Russian State Pedagogical University
- Issue: Vol 95, No 4 (2023)
- Pages: 322-326
- Section: Original articles
- URL: https://journals.rcsi.science/0040-3660/article/view/132923
- DOI: https://doi.org/10.26442/00403660.2023.04.202147
- ID: 132923
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Abstract
Aim. To analyze the anti-inflammatory efficacy of Regasthym Gastro (alpha-glutamyl-tryptophan) in the treatment of patients with chronic atrophic gastritis according to endoscopic and morphometric studies.
Materials and methods. As part of a double-blind placebo-controlled study, the results of gastroscopy and histological (morphometric) studies were retrospective analyzed in 80 patients diagnosed with chronic atrophic gastritis associated with Helicobacter pylori in exacerbation: 43 patients took Regasthym Gastro, 37 patients – placebo. The conclusions of the gastroscopy were structured in the form of a standardized scale, which included an assessment of criteria in points (from 0 to 3): thickness of folds, hyperemia, edema of the gastric mucosa, the signs of atrophy, metaplasia; the severity of the erosive process. The sum of points according to all criteria was used to assess the dynamics of the inflammatory process: positive dynamics; lack of dynamics; the pathological process is progressing. The results of the endoscopic examination were compared with morphometry data (the number of inflammation pool cells per 1 mm2 of gastric mucosa). Statistical processing of the results was carried out using the Statistica 12 application software package.
Results. According to the gastroscopy, before therapy, hyperemia of the gastric mucosa was present in 82.5%, edema – in 53.8%, erosion – in 17.5%, signs of metaplasia – in 12.5% of patients. After therapy with the investigated drug a statistically significant decrease in the severity of edema of the gastric mucosa (p=0.008), the total set of signs of acute inflammatory process (p=0.006), a decrease in the proportion of outcomes with negative dynamics of the inflammatory process (p=0.038) was revealed. Statistically significant (p<0.05) correlations were found between gastroscopy data of inflammation and the number of neutrophil, eosinophil granulocytes, macrophages and lymphocytes per 1 mm2.
Conclusion. Regasthym Gastro contributes to a significant decrease in the severity of the inflammatory process according to the evaluation of the results of gastroscopy and morphometry. It is possible to recommend the inclusion of this drug in the complex therapy of chronic gastritis to increase the effectiveness and reduce the risks of progression of inflammation.
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##article.viewOnOriginalSite##About the authors
Natalia V. Baryshnikova
Saint Petersburg State Pediatric Medical University; Pavlov First Saint Petersburg State Medical University; Institute of Experimental Medicine
Email: uspenskiy65@mail.ru
ORCID iD: 0000-0001-7429-0336
канд. мед. наук, доц., мл. науч. сотр. лаб. медико-социальных проблем педиатрии ФГБОУ ВО СПбГПМУ, доц. каф. внутренних болезней стоматологического фак-та ФГБОУ ВО «ПСПбГМУ им. акад. И.П. Павлова», науч. сотр. лаб. молекулярной микробиологии ФГБНУ ИЭМ
Russian Federation, Saint Petersburg; Saint Petersburg; Saint PetersburgYury P. Uspenskiy
Saint Petersburg State Pediatric Medical University; Pavlov First Saint Petersburg State Medical University
Author for correspondence.
Email: uspenskiy65@mail.ru
ORCID iD: 0000-0001-6434-1267
д-р мед. наук, проф., зав. каф. факультетской терапии им. В.А. Вальдмана ФГБОУ ВО СПбГПМУ, проф. каф. внутренних болезней стоматологического фак-та ФГБОУ ВО «ПСПбГМУ им. акад. И.П. Павлова»
Russian Federation, Saint Petersburg; Saint PetersburgYulia A. Fominykh
Saint Petersburg State Pediatric Medical University; Pavlov First Saint Petersburg State Medical University
Email: uspenskiy65@mail.ru
ORCID iD: 0000-0002-2436-3813
д-р мед. наук, проф. каф. факультетской терапии им. В.А. Вальдмана ФГБОУ ВО СПбГПМУ, доц. каф. внутренних болезней стоматологического фак-та ФГБОУ ВО «ПСПбГМУ им. акад. И.П. Павлова»
Russian Federation, Saint Petersburg; Saint PetersburgSergey V. Petlenko
Golikov Research Clinical Center of Toxicology
Email: uspenskiy65@mail.ru
ORCID iD: 0000-0002-2752-4598
д-р мед. наук, вед. науч. сотр. ФГБУ «НКЦТ им. акад. С.Н. Голикова»
Russian Federation, Saint PetersburgVasiliy A. Zaplutanov
Saint Petersburg Institute of Bioregulation and Gerontology
Email: uspenskiy65@mail.ru
ORCID iD: 0000-0001-5294-6533
науч. сотр. лаб. фармакологии пептидов АННО ВО НИЦ СПбИБГ
Russian Federation, Saint PetersburgVera A. Apryatina
Saint Petersburg State University
Email: uspenskiy65@mail.ru
ORCID iD: 0000-0002-9819-6835
канд. мед. наук, ст. науч. сотр. лаб. нейробиологии и молекулярной фармакологии Института трансляционной биомедицины ФГБОУ ВО СПбГУ
Russian Federation, Saint PetersburgAlexey A. Krasnov
Herzen Russian State Pedagogical University
Email: uspenskiy65@mail.ru
ORCID iD: 0000-0002-8732-6390
д-р мед. наук, доц. каф. медико-валеологических дисциплин
Russian Federation, Saint PetersburgReferences
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