Effectiveness of empirical Helicobacter pylori eradication therapy with furazolidone in Russia: results from the European Registry on Helicobacter pylori Management (Hp-EuReg)

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Abstract

Background. First-line therapy does not always provide a high level of Helicobacter pylori eradication due to the increase of H. pylori resistance to antibiotics; therefore, it remains necessary to identify the most effective rescue treatments. The purpose of this study was to evaluate the efficacy and safety of empirical H. pylori furazolidone-containing regimens.

Materials and methods. Adult H. pylori infected patients empirically treated with furazolidone-containing eradication regimens were registered in an international, prospective, multicenter non-intervention European registry on H. pylori management (Hp-EuReg). Data were collected at AEG-REDCap e-CRF from 2013 to 2021 and the quality was reviewed. Modified intention-to-treat (mITT) effectiveness analyses were performed.

Results. Overall 106 patients received empirical furazolidone-containing therapy in Russia. Furazolidone was prescribed in a sequential scheme along with amoxicillin, clarithromycin and a proton pump inhibitor in 68 (64%) cases, triple regimens were prescribed in 28 (26%) patients and quadruple regimens in 10 (9.4%). Treatment duration of 7 days was assigned to 2 (1.9%) patients, 10-day eradication therapy in case of 80 (75%) and 14 days – in 24 (23%) patients. Furazolidone was mainly used in first- (79%) and second-line (21%) regimens. The methods used to diagnose H. pylori infection were: histology (81%), stool antigen test (64%), 13C-urea breath test (6.6%), and rapid urease test (1.9%). The mITT effectiveness of sequential therapy was 100%; 93% with the triple therapy and 75.5% with quadruple therapy. Compliance was reported in 98% of cases. Adverse events were revealed in 5.7% of patients, mostly nausea (3.8%). No serious adverse events were reported.

Conclusion. Furazolidone containing eradication regimens appear to be an effective and safe empirical therapy in Russia.

About the authors

Dmitry S. Bordin

Loginov Moscow Clinical Scientific Center; Yevdokimov Moscow State University of Medicine and Dentistry; Tver State Medical University

Author for correspondence.
Email: d.bordin@mknc.ru
ORCID iD: 0000-0003-2815-3992

д-р мед. наук, зав. отд. патологии поджелудочной железы, желчных путей и верхних отделов пищеварительного тракта, проф. каф. пропедевтики внутренних болезней и гастроэнтерологии, проф. каф. общей врачебной практики и семейной медицины фак-та дополнительного профессионального образования

Russian Federation, Moscow; Moscow; Tver

Irina N. Voynovan

Loginov Moscow Clinical Scientific Center

Email: d.bordin@mknc.ru
ORCID iD: 0000-0002-5584-8514

канд. мед. наук, науч. сотр. отд-ния патологии верхних отделов пищеварительного тракта

Russian Federation, Moscow

Aiman S. Sarsenbaeva

South Ural State Medical University

Email: d.bordin@mknc.ru
ORCID iD: 0000-0001-5922-2271

д-р мед. наук, проф. каф. терапии, декан Института дополнительного профессионального образования

Russian Federation, Chelyabinsk

Oleg V. Zaytsev

First Clinical Medical Centre

Email: d.bordin@mknc.ru
ORCID iD: 0000-0002-5878-5280

врач-гастроэнтеролог, вед. специалист рук. терапевтического центра

Russian Federation, Kovrov

Rustam A. Abdulkhakov

Kazan State Medical University

Email: d.bordin@mknc.ru
ORCID iD: 0000-0002-1509-6776

д-р мед. наук, проф., проф. каф. госпитальной терапии

Russian Federation, Kazan

Natalia V. Bakulina

Mechnikov North-Western State Medical University

Email: d.bordin@mknc.ru
ORCID iD: 0000-0003-4075-4096

д-р мед. наук, зав. каф. терапии, клинической фармакологии и нефрологии

Russian Federation, Saint Petersburg

Igor G. Bakulin

Mechnikov North-Western State Medical University

Email: d.bordin@mknc.ru
ORCID iD: 0000-0002-6151-2021

д-р мед. наук, проф., зав. каф. пропедевтики внутренних болезней, гастроэнтерологии и диетологии им. С.М. Рысса

Russian Federation, Saint Petersburg

Marina F. Osipenko

Novosibirsk State Medical University

Email: d.bordin@mknc.ru
ORCID iD: 0000-0002-5156-2842

д-р мед. наук, проф., зав. каф. пропедевтики внутренних болезней

Russian Federation, Novosibirsk

Maria A. Livzan

Omsk State Medical University

Email: d.bordin@mknc.ru
ORCID iD: 0000-0002-6581-7017

чл.-кор. РАН, д-р мед. наук, проф., зав каф. факультетской терапии, ректор

Russian Federation, Omsk

Sergei A. Alekseenko

Far Eastern State Medical University

Email: d.bordin@mknc.ru
ORCID iD: 0000-0003-1724-9980

д-р мед. наук, проф., зав. каф. госпитальной терапии

Russian Federation, Khabarovsk

Larisa V. Tarasova

Ulianov Chuvash State University

Email: d.bordin@mknc.ru
ORCID iD: 0000-0003-1496-0689

д-р мед. наук, зав. каф. факультетской и госпитальной терапии

Russian Federation, Cheboksary

Galina N. Tarasova

Rostov State Medical University

Email: d.bordin@mknc.ru
ORCID iD: 0000-0003-4054-9180

д-р мед. наук, проф., проф. каф. пропедевтики внутренних болезней

Russian Federation, Rostov-on-Don

Pavel O. Bogomolov

Yevdokimov Moscow State University of Medicine and Dentistry; Private Medical Center “Universal”; Vladimirsky Moscow Regional Clinical Research Institute

Email: d.bordin@mknc.ru
ORCID iD: 0000-0003-2346-1216

канд. мед. наук, доц. каф. пропедевтики внутренних болезней и гастроэнтерологии, врач-гастроэнтеролог, рук. отд-ния и вед. науч. сотр. гепатологического отд-ния

Russian Federation, Moscow; Moscow; Moscow

Igor V. Maev

Yevdokimov Moscow State University of Medicine and Dentistry

Email: d.bordin@mknc.ru
ORCID iD: 0000-0001-6114-564X

акад. РАН, д-р мед. наук, проф., зав. каф. пропедевтики внутренних болезней и гастроэнтерологии

Russian Federation, Moscow

Dmitry N. Andreev

Yevdokimov Moscow State University of Medicine and Dentistry

Email: d.bordin@mknc.ru
ORCID iD: 0000-0002-4007-7112

канд. мед. наук, доц. каф. пропедевтики внутренних болезней и гастроэнтерологии, науч. сотр. лаб. функциональных методов исследования в гастроэнтерологии

Russian Federation, Moscow

Sayar R. Abdulkhakov

Kazan State Medical University; Kazan Federal University

Email: d.bordin@mknc.ru
ORCID iD: 0000-0001-9542-3580

канд. мед. наук, доц., доц. каф. поликлинической терапии и общей врачебной практики, зав. каф. внутренних болезней, ст. науч. сотр.

Russian Federation, Kazan; Kazan

Boris D. Starostin

City Polyclinic №38

Email: d.bordin@mknc.ru

зав. Межрайонного гастроэнтерологического центра 1

Russian Federation, Saint Petersburg

Natalia V. Bakanova

Medical Center “Medicea”

Email: d.bordin@mknc.ru
ORCID iD: 0000-0001-9724-0622

канд. мед. наук, зав. гастроэнтерологической службой, врач-гастроэнтеролог

Russian Federation, Izhevsk

Alla G. Kononova

Tver State Medical University

Email: d.bordin@mknc.ru
ORCID iD: 0000-0002-4525-0885

канд. мед. наук, доц. каф. поликлинической терапии и семейной медицины

Russian Federation, Tver

Sergei V. Kolbasnikov

Tver State Medical University

Email: d.bordin@mknc.ru
ORCID iD: 0000-0002-9223-0457

д-р мед. наук, проф., зав. каф. поликлинической терапии и семейной медицины

Russian Federation, Tver

Elena L. Bueverova

Sechenov First Moscow State Medical University (Sechenov University)

Email: d.bordin@mknc.ru
ORCID iD: 0000-0002-0700-9775

канд. мед. наук, доц. каф. пропедевтики внутренних болезней, гастроэнтерологии и гепатологии Института клинической медицины им. Н.В. Склифосовского

Russian Federation, Moscow

Leticia Moreira

Hospital Clínic de Barcelona; Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBERehd); University of Barcelona

Email: d.bordin@mknc.ru
ORCID iD: 0000-0002-4518-8591

IDIBAPS (Institut d’Investigacions Biomèdiques August Pi i Sunyer)

Spain, Barcelona; Madrid; Barcelona

Francis Megraud

Université de Bordeaux

Email: d.bordin@mknc.ru
ORCID iD: 0000-0002-2481-1612

Professor of Bacteriology

France, Bordeaux

Colm O'Morain

Trinity College Dublin

Email: d.bordin@mknc.ru
ORCID iD: 0000-0002-1847-6782

Department of Gastroenterology, UEG President 2011–2013, Emeritus Professor of Medicine

Ireland, Dublin

Olga Perez Nyssen

Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd); Universidad Autónoma de Madrid (UAM)

Email: d.bordin@mknc.ru
ORCID iD: 0000-0002-4920-9310

Gastroenterology Unit, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-Princesa)

Spain, Madrid; Madrid

Javier Perez Gisbert

Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd); Universidad Autónoma de Madrid (UAM)

Email: d.bordin@mknc.ru
ORCID iD: 0000-0003-2090-3445

Gastroenterology Unit, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-Princesa)

Madrid; Madrid

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Copyright (c) 2023 Bordin D.S., Voynovan I.N., Sarsenbaeva A.S., Zaytsev O.V., Abdulkhakov R.A., Bakulina N.V., Bakulin I.G., Osipenko M.F., Livzan M.A., Alekseenko S.A., Tarasova L.V., Tarasova G.N., Bogomolov P.O., Maev I.V., Andreev D.N., Abdulkhakov S.R., Starostin B.D., Bakanova N.V., Kononova A.G., Kolbasnikov S.V., Bueverova E.L., Moreira L., Megraud F., O'Morain C., Perez Nyssen O., Gisbert J.

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