Email this article New opportunities of antithrombotic therapy in patients with type 2 diabetes mellitus and stable coronary heart disease for reducing the cardiovascular risk and cardiovascular complications: THEMIS, THEMIS-PCI trials
- Authors: Kalashnikov V.I.1, Michurova M.S.1
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Affiliations:
- National Medical Research Center for Endocrinology
- Issue: Vol 94, No 10 (2022)
- Pages: 1204-1210
- Section: Reviews
- URL: https://journals.rcsi.science/0040-3660/article/view/114799
- DOI: https://doi.org/10.26442/00403660.2022.10.201911
- ID: 114799
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Abstract
Patients with diabetes mellitus (DM) and coronary heart disease belong to a group with a very high risk of developing cardiovascular disease. In patients with coronary atherosclerosis, DM increases the risk of ischemic events by 2–4 times. Apparently, increased antithrombotic therapy has an advantage in patients with DM who have had myocardial infarction. However, until recently it was not clear there is such an advantage in patients with DM and stable coronary artery disease without prior myocardial infarction. The addition of ticagrelol to monotherapy of acetylsalicylic acid reduces the risk of major cardiovascular events in patients with type 2 DM and stable coronary artery disease undergoing percutaneous coronary intervention, if patients have a high risk of ischemic events.
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##article.viewOnOriginalSite##About the authors
Victor I. Kalashnikov
National Medical Research Center for Endocrinology
Author for correspondence.
Email: victor9368@gmail.com
ORCID iD: 0000-0001-5573-0754
чл.-кор. РАН, д-р мед. наук, проф., зав. отд. кардиологии и сосудистой хирургии
Russian Federation, MoscowMarina S. Michurova
National Medical Research Center for Endocrinology
Email: M.michurova@yandex.ru
ORCID iD: 0000-0003-1495-5847
науч. сотр., врач-кардиолог, эндокринолог отд-ния кардиологии, эндоваскулярной и сосудистой хирургии
Russian Federation, MoscowReferences
- Steg PG, Bhatt DL, Simon T, et al. Ticagrelor in Patients with Stable Coronary Disease and Diabetes. N Engl J Med. 2019;381(14):1309. doi: 10.1056/NEJMoa1908077
- Bonaca MP, Bhatt DL, Braunwald E, et al. Design and rationale for the Prevention of Cardiovascular Events in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin-Thrombolysis in Myocardial Infarction 54 (PEGASUSTIMI 54) trial. Am Heart J. 2014;167(4):437-44. doi: 10.1016/j.ahj.2013.12.020
- Abtan J, Bhatt DL, Held C, et al. Incidence of Myocardial Infarction Types in Patients Treated With Ticagrelor in the THEMIS Trial. Circ Cardiovasc Interv. 2021;14(12):e011035. doi: 10.1161/CIRCINTERVENTIONS.120.011035
- Bhatt DL, Steg PG, Mehta SR, et al. Ticagrelor in patients with diabetes and stable coronary artery disease with a history of previous percutaneous coronary intervention (THEMIS-PCI): a phase 3, placebo-controlled, randomised trial. Lancet. 2019;394(10204):1169-80. doi: 10.1016/S0140-6736(19)31887-2
- Leiter LA, Bhatt DL, McGuire DK, et al. THEMIS Steering Committee and Investigators. Diabetes-Related Factors and the Effects of Ticagrelor Plus Aspirin in the THEMIS and THEMIS-PCI Trials. J Am Coll Cardiol. 2021;77(19):2366-77. doi: 10.1016/j.jacc.2021.03.298
- Ducrocq G, Bhatt DL, Lee JJ, et al. Balance of benefit and risk of ticagrelor in patients with diabetes and stable coronary artery disease according to bleeding risk assessment with the CRUSADE score: Data from THEMIS and THEMIS PCI. Am Heart J. 2022;249:23-33. doi: 10.1016/j.ahj.2022.03.008
- Bhatt DL, Cryer BL, Contant CF, et al. Clopidogrel with or without omeprazole in coronary artery disease. N Engl J Med. 2010;363:1909-17. doi: 10.1056/NEJMoa1007964
- American Diabetes Association; 10. Cardiovascular Disease and Risk Management: Standards of Medical Care in Diabetes – 2019. Diabetes Care. 2019;42 (Suppl. 1):S103-23. doi: 10.2337/dc19-S010
- Jung JH, Tantry US, Gurbel PA, Jeong YH. Current antiplatelet treatment strategy in patients with diabetes mellitus. Diabetes Metab J. 2015;39(2):95-113. doi: 10.4093/dmj.2015.39.2.95
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