Prevalence of combination of functional dyspepsia and irritable bowel syndrome: a meta-analysis of studies using the Rome III–IV Criteria
- Authors: Andreev D.N.1, Bordin D.S.1,2,3, Vyuchnova E.S.1, Lebedeva E.G.1, Dicheva D.T.1, Umyarova R.M.1, Maev I.V.1
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Affiliations:
- Yevdokimov Moscow State University of Medicine and Dentistry
- Loginov Moscow Clinical Scientific Center
- Tver State Medical University
- Issue: Vol 94, No 9 (2022)
- Pages: 1099-1108
- Section: Original articles
- URL: https://journals.rcsi.science/0040-3660/article/view/112055
- DOI: https://doi.org/10.26442/00403660.2022.09.201849
- ID: 112055
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Abstract
Aim. To systematize data on the prevalence of the combination of functional dyspepsia (FD) and irritable bowel syndrome (IBS) using the Rome III–IV Criteria.
Materials and methods. A search in electronic databases MEDLINE/PubMed, EMBASE, and Cochrane was conducted. The depth of search was 17 years (from January 2006 to May 2022). Original publications from peer-reviewed periodicals that applied the Rome III–IV Criteria for diagnosis of FD and IBS in an adult patient population with detailed descriptive statistics to allow the resulting data to be included in the meta-analysis were selected for final analysis.
Results. The final analysis included 38 studies involving 17,993 patients with FD and 15,883 patients with IBS. In the overall pool of studies using the Rome III–IV Criteria, the pooled prevalence of FD in patients with IBS was 34.625% (95% confidence interval [CI] 28.159–41.390), and the pooled prevalence of IBS in patients with FD was 37.549% (95% [CI] 31.511–43.787). A random-effects model was used in the analyses since significant heterogeneity between results was found (p<0.0001; I2>98%). Using the Rome III Criteria, the pooled prevalence of FD in patients with IBS was 31.993% (95% CI 26.135–38.150; I2=98.17%), while the prevalence of IBS in patients with FD was 34.694% (95% [CI] 29.319–40.273; I2=97,89%). An analysis of papers using the Rome IV Criteria demonstrated that the pooled prevalence of FD in patients with IBS was 42.614% (95% CI 18.588–68.675; I2=98.97%), and the prevalence of IBS in patients with FD was 50.444% (95% CI 37.956–62.904; I2=94,39%).
Conclusion. This meta-analysis demonstrated that the prevalence of the combination of FD and IBS identified using the Rome III–IV Criteria is high and is reported in approximately 1 in 3 patients with the functional gastrointestinal disorders concerned. The prevalence of a combination of FD and IBS identified using the Rome IV Criteria is at least 10% higher than that using the Rome III Criteria.
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##article.viewOnOriginalSite##About the authors
Dmitry N. Andreev
Yevdokimov Moscow State University of Medicine and Dentistry
Author for correspondence.
Email: dna-mit8@mail.ru
ORCID iD: 0000-0002-4007-7112
канд. мед. наук, доц. каф. пропедевтики внутренних болезней и гастроэнтерологии
Russian Federation, MoscowDmitry S. Bordin
Yevdokimov Moscow State University of Medicine and Dentistry; Loginov Moscow Clinical Scientific Center; Tver State Medical University
Email: dna-mit8@mail.ru
ORCID iD: 0000-0003-2815-3992
д-р мед. наук, проф. каф. пропедевтики внутренних болезней и гастроэнтерологии; зав. отд. патологии поджелудочной железы, желчных путей и верхних отделов пищеварительного тракта; проф. каф. общей врачебной практики и семейной медицины
Russian Federation, Moscow; Moscow; TverElena S. Vyuchnova
Yevdokimov Moscow State University of Medicine and Dentistry
Email: dna-mit8@mail.ru
ORCID iD: 0000-0002-3842-0452
канд. мед. наук, доц. каф. пропедевтики внутренних болезней и гастроэнтерологии
Russian Federation, MoscowEkaterina G. Lebedeva
Yevdokimov Moscow State University of Medicine and Dentistry
Email: dna-mit8@mail.ru
ORCID iD: 0000-0001-9572-1932
канд. мед. наук, доц. каф. пропедевтики внутренних болезней и гастроэнтерологии
Russian Federation, MoscowDiana T. Dicheva
Yevdokimov Moscow State University of Medicine and Dentistry
Email: dna-mit8@mail.ru
ORCID iD: 0000-0001-9224-7382
канд. мед. наук, доц. каф. пропедевтики внутренних болезней и гастроэнтерологии
Russian Federation, MoscowRenata M. Umyarova
Yevdokimov Moscow State University of Medicine and Dentistry
Email: dna-mit8@mail.ru
ORCID iD: 0000-0002-9390-8303
клин. ординатор каф. пропедевтики внутренних болезней и гастроэнтерологии
Russian Federation, MoscowIgor V. Maev
Yevdokimov Moscow State University of Medicine and Dentistry
Email: dna-mit8@mail.ru
ORCID iD: 0000-0001-6114-564X
акад. РАН, д-р мед. наук, проф., зав. каф. пропедевтики внутренних болезней и гастроэнтерологии
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Supplementary files
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