Clinical-anthropometric and laboratory-instrumental characteristics of iron deficiency states in children with celiac disease

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Abstract

Aim. To increase detection frequency and reduce the risk of celiac disease complications based on a comprehensive analysis of patterns of iron deficiency states in the active period of celiac disease in children.

Materials and methods. 228 children diagnosed with celiac disease, aged 8 months to 18 years, were enrolled. Forms of iron deficiency (ID) were determined according to the complete blood count.

Results. The median age of onset was 1.0 [0.6; 2.6] years in children without ID; 1.0 [0.5; 2.1] years in the latent iron deficiency (LID) group and 1.2 [0.5; 3.0] years in children with iron deficiency anemia (IDA). The median age at diagnosis of celiac disease in the analyzed groups was years, respectively. Gastrointestinal symptoms of celiac disease were more common in children with IDA, who were diagnosed with total villous atrophy of the small intestinal mucosa (SIM) in 82.1% of cases, which was 5 times higher than in children with LID (p=0.001) and 2.5 times higher than in children without IDS (p=0.001).

Conclusion. Iron deficiency states in the active period of celiac disease have been diagnosed in 73.3% of patients, with the highest incidence observed in infants and older children.

About the authors

Tatiana A. Ivenskaya

Stavropol State Medical University

Author for correspondence.
Email: ivenskaya.tatyana95@mail.ru
ORCID iD: 0000-0003-1265-3124

ординатор 2-го года обучения, ст. лаборант каф. факультетской педиатрии

Russian Federation, Stavropol

Leonid Ya. Klimov

Stavropol State Medical University

Email: ivenskaya.tatyana95@mail.ru
ORCID iD: 0000-0001-7248-1614

д-р мед. наук, доц., зав. каф. факультетской педиатрии

Russian Federation, Stavropol

Victoria A. Kuryaninova

Stavropol State Medical University

Email: ivenskaya.tatyana95@mail.ru
ORCID iD: 0000-0002-0731-7153

канд. мед. наук, доц. каф. пропедевтики детских болезней

Russian Federation, Stavropol

Anastasya V. Yagupova

Stavropol State Medical University

Email: ivenskaya.tatyana95@mail.ru
ORCID iD: 0000-0002-3503-306X

канд. мед. наук, доц. каф. факультетской педиатрии

Russian Federation, Stavropol

Marina V. Stoyan

Stavropol State Medical University

Email: ivenskaya.tatyana95@mail.ru
ORCID iD: 0000-0002-7390-6204

канд. мед. наук, ассистент каф. факультетской педиатрии

Russian Federation, Stavropol

References

  1. Шаповалова Н.С., Новикова В.П., Ревнова М.О., и др. Гастроинтестинальные факторы риска развития анемии у детей с целиакией. Педиатр. 2019;10(5):5-12 [Shapovalova NS, Novikova VP, Revnova MO, et al. Gastrointestinal risk factors for anemia in children with celiac disease. Pediatrician. 2019;10(5):5-12 (in Russian)]. doi: 10.17816/PED1055-12
  2. Lebwohl B, Sanders DS, Green PHR. Coeliac disease. Lancet. 2018;391(10115):70-81. doi: 10.1016/S0140-6736(17)31796-8
  3. Stefanelli G, Viscido A, Longo S, et al. Persistent Iron Deficiency Anemia in Patients with Celiac Disease Despite a Gluten-Free Diet. Nutrients. 2020;12(8):2176. doi: 10.3390/nu12082176
  4. Gubska O, Kuzminets А, Naumova O, et al. Study of iron deficiency conditions in patients with gluten-related disorders who are on a gluten-free diet. Gastroenterology. 2020;54(1):30-7. doi: 10.22141/2308-2097.54.1.2020.199139
  5. Парфенов А.И., Быкова С.В., Сабельникова Е.А., и др. Всероссийский консенсус по диагностике и лечению целиакии у детей и взрослых. Терапевтический архив. 2017;89(3):94-107 [Parfenov AI, Bykova SV, Sabelnikova EA, et al. All-Russian Consensus on Diagnosis and Treatment of Celiac Diseasein Children and Addults. Terapevticheskii Arkhiv (Ter. Arkh). 2017;89(3):94-107 (in Russian)]. doi: 10.17116/terarkh201789394-107
  6. Быкова С.В., Парфенов А.И., Сабельникова Е.А. Эпидемиология целиакии в мире. Альманах клинической медицины. 2018;46(1):23-31 [Bykova SV, Parfenov AI, Sabel'nikova EA. Global epidemiology of celiac disease. Almanac of Clinical Medicine. 2018;46(1):23-31 (in Russian)]. doi: 10.18786/2072-0505-2018-46-1-23-31
  7. Быкова С.В., Сабельникова Е.А., Гудкова Р.Б., и др. Скрининг целиакии среди больных гастроэнтерологического профиля. Терапевтический архив. 2021;93(2):145-9 [Bykova SV, Sabelnikova EA, Gudkova RB, et al. Screening for celiac disease among patients of the gastroenterological profile. Terapevticheskii Arkhiv (Ter. Arkh). 2021;93(2):145-9 (in Russian)]. doi: 10.26442/00403660.2021.02.200625
  8. Montoro-Huguet MA, Santolaria-Piedrafita S, Cañamares-Orbis P, García-Erce JA. Iron deficiency in celiac disease: prevalence, health impact, and clinical management. Nutrients. 2021;13(10):3437. doi: 10.3390/nu13103437
  9. Mahadev S, Laszkowska M, Sundström J, et al. Prevalence of Celiac Disease in Patients With iron deficiency anemia-a systematic review with meta-analysis. Gastroenterology. 2018;155(2):374-382.e1. doi: 10.1053/j.gastro.2018.04.016
  10. Бельмер С.В., Митина Е.В., Карпина Л.М., и др. Железодефицитная анемия и анемия хронического заболевания при целиакии у детей. Экспериментальная и клиническая гастроэнтерология. 2014;1(101):23-9 [Belmer SV, Mitina EV, Karpina LM, Smetanina NS. Iron deficiency anemia and chronic disease anemia in celiac disease in children. Experimental and clinical gastroenterology. 2014;1(101):23-9 (in Russian)].
  11. Husby S, Koletzko S, Korponay-Szabó IR, Mearin ML, et al; ESPGHAN Working Group on Coeliac Disease Diagnosis; ESPGHAN Gastroenterology Committee; European Society for Pediatric Gastroenterology, Hepatology, and Nutrition. European Society for Pediatric Gastroenterology, Hepatology, and Nutrition guidelines for the diagnosis of coeliac disease. J Pediatr Gastroenterol Nutr. 2012; 54(1):136-60. doi: 10.1097/MPG.0b013e31821a23d0
  12. Румянцев А.Г. Детская гематология: клинические рекомендации. Под ред. А.Г. Румянцева, А.А. Масчана, Е.В. Жуковской. М.: ГЭОТАР-Медиа; 2015 [Rumyantsev AG. Detskaya gematologiya: Clinical guidelines. AG Rumyantsev, AA Maschana, EV Zhukovskaya. Moscow: GEOTAR-Media; 2015 (in Russian)].
  13. Балашова Е.Л., Мазур Л.И. Современные подходы к диагностике железодефицитной анемии у детей. Российский вестник перинатологии и педиатрии. 2015;60(4):31-6 [Balashova EA, Mazur LI. Current approaches to diagnosing iron-deficiency anemia in children. Russian Bulletin of Perinatology and Pediatrics. 2015;60(4):31-6 (in Russian)].
  14. Парфенов А.И., Акопова А.О., Щербаков П.Л., и др. Нужна ли видеокапсульная эндоскопия для диагностики целиакии? Терапевтический архив. 2018;90(4):8-11 [Parfenov AI, Akopova AO, Shherbakov PL, et al. Is it necessary to use capsular endoscopy to diagnose celiac disease? Terapevticheskii Arkhiv (Ter. Arkh). 2018;90(4):8–11 (in Russian)]. doi: 10.26442/terarkh20189048-11
  15. Румянцев А.Г., Захарова И.Н., Чернов В.М., и др. Распространенность железодефицитных состояний и факторы, на нее влияющие. Медицинский Совет. 2015;6:62-6 [Rumyantsev AG, Zakharova IN, Chernov VM, et al. Prevalence of iron deficiency related conditions and the contributing factors. Medical Council. 2015;6:62-6 (in Russian)]. doi: 10.21518/2079-701X-2015-6-62-66
  16. Baghbanian M, Farahat A, Vahedian HA, et al. The prevalence of celiac disease in patients with iron-deficiency anemia in center and south area of Iran. Arq Gastroenterol. 2015;52(4):278-82. doi: 10.1590/S0004-28032015000400006

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2. Fig. 1. Frequency of children with iron deficiency anemia (IDA), latent iron deficiency (LID) and without iron deficiency states (IDS), examined in the active period of celiac disease, depending on the age at diagnosis.

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3. Fig. 2. The ratio of IDSs forms in children with celiac disease, examined in the active period, depending on the age at diagnosis

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4. Fig. 3. Frequency of children with IDA, LID and without IDSs, examined in the active period of celiac disease, depending on the duration of the latent period.

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