Email this article Assessment of exo- and endocrine function of pancreas following distal pancreatectomy
- Authors: Malykh M.V.1, Dubtsova E.A.1, Vinokurova L.V.1, Les’ko K.A.1, Dorofeev A.S.1, Kiryukova M.A.1, Savina I.V.1, Tsvirkun V.V.1, Bordin D.S.1,2,3
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Affiliations:
- Loginov Moscow Clinical Scientific and Practical Center
- Yevdokimov Moscow State University of Medicine and Dentistry
- Tver State Medical University
- Issue: Vol 94, No 2S (2022)
- Pages: 343-348
- Section: Conference proceedings
- URL: https://journals.rcsi.science/0040-3660/article/view/110778
- DOI: https://doi.org/10.26442/00403660.2022.02.201386
- ID: 110778
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Abstract
Aim. The assessment of pancreatic resection volume influence on exo- and endocrine pancreatic functions.
Materials and methods. The resected pancreatic volume influence was assessed in 47 patients: 31 (66%) patients after resections of pancreatic body and tail, and 16 (34%) patients after distal resections. The exocrine pancreatic function was assessed by pancreatic fecal elastase 1 as well as endocrine pancreatic function was assessed by C-peptide level measurement. Computed tomography with intravenous contrast enhancement and postprocessing was used for pre- and postoperative pancreatic volume assessment. All tests were performed before and 1, 3, and 6 months after surgery.
Results. Type of surgery had no influence on C-peptide and pancreatic fecal elastase 1 levels (p>0.05). Exo- and endocrine pancreatic functions markers tended to decrease in 1st month after surgery with consequent functions restoration towards 6 months after surgery. There were 15 (35.7%) patients from 42 patients with normal exocrine pancreatic function with a fecal elastase 1 level decrease to 114.7±61.8 μg/g; exocrine insuficiency remained only in 2 (4.8%) patients after 6 months after surgery. C-peptide concentration decrease before surgery to less than 1.1 ng/ml was noticed only in 8 (17%) patients. C-peptide concentration decreased in 30 (63.8%) patients in 1st month after surgery, but after 6 months after surgery, C-peptide level decrease was only in 7 (14.9%) patients.
Conclusion. The exo- and endocrine function of the pancreas is restored in more than 80% of patients after DR. Probably it could be associated with the activation of the pancreatic compensatory abilities.
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##article.viewOnOriginalSite##About the authors
Marina V. Malykh
Loginov Moscow Clinical Scientific and Practical Center
Author for correspondence.
Email: m.malykh@mknc.ru
ORCID iD: 0000-0002-2480-5191
мл. науч. сотр. отд-ния патологии поджелудочной железы и желчевыводящих путей
Russian Federation, MoscowElena A. Dubtsova
Loginov Moscow Clinical Scientific and Practical Center
Email: m.malykh@mknc.ru
ORCID iD: 0000-0002-6556-7505
д-р мед. наук, зав. отд-нием патологии поджелудочной железы и желчных путей
Russian Federation, MoscowLyudmila V. Vinokurova
Loginov Moscow Clinical Scientific and Practical Center
Email: m.malykh@mknc.ru
ORCID iD: 0000-0002-4556-4681
д-р мед. наук, вед. науч. сотр. отд-ния патологии поджелудочной железы и желчевыводящих путей
Russian Federation, MoscowKonstantin A. Les’ko
Loginov Moscow Clinical Scientific and Practical Center
Email: m.malykh@mknc.ru
ORCID iD: 0000-0001-9814-0172
канд. мед. наук, врач-рентгенолог рентгеновского отд-ния
Russian Federation, MoscowAlexey S. Dorofeev
Loginov Moscow Clinical Scientific and Practical Center
Email: m.malykh@mknc.ru
ORCID iD: 0000-0002-8515-6658
мл. науч. сотр. лаб. научно-диагностических исследований
Russian Federation, MoscowMaria A. Kiryukova
Loginov Moscow Clinical Scientific and Practical Center
Email: m.malykh@mknc.ru
ORCID iD: 0000-0002-6946-3826
мл. науч. сотр. отд-ния патологии поджелудочной железы и желчевыводящих путей
Russian Federation, MoscowIrina V. Savina
Loginov Moscow Clinical Scientific and Practical Center
Email: m.malykh@mknc.ru
ORCID iD: 0000-0001-7142-3885
врач-гастроэнтеролог отд-ния патологии поджелудочной железы и желчевыводящих путей
Russian Federation, MoscowVictor V. Tsvirkun
Loginov Moscow Clinical Scientific and Practical Center
Email: m.malykh@mknc.ru
ORCID iD: 0000-0001-5169-2199
д-р мед. наук, проф., гл. науч. сотр.
Russian Federation, MoscowDmitry S. Bordin
Loginov Moscow Clinical Scientific and Practical Center; Yevdokimov Moscow State University of Medicine and Dentistry; Tver State Medical University
Email: m.malykh@mknc.ru
ORCID iD: 0000-0003-2815-3992
д-р мед. наук, зав. отд. патологии поджелудочной железы, желчевыводящих путей и патологии верхних отделов пищеварительного тракта, проф. каф. пропедевтики внутренних болезней и гастроэнтерологии, проф. каф. поликлинической терапии и семейной медицины ФПДО
Russian Federation, Moscow; Moscow; TverReferences
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