Endogenous estrogen deficiency and the development of chronic musculoskeletal pain: A review

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Abstract

Sexual dimorphism of chronic diseases is a phenomenon determined by differences in the hormonal status of men and women. In this regard, estrogens, which have a complex effect on the body, are of great interest. In particular, estrogens play an important role in the natural control of pain and inflammation. A decrease in estrogen levels associated with menopause or iatrogenic effects (hysterectomy, use of aromotase inhibitors), as well as mutations of genes responsible for the synthesis of structural components of membrane estrogen receptors (ESR1 and ESR2), can significantly reduce the positive effects of these hormones. Deficiency of estrogen can become one of the reasons for the development of serious pathological changes – in particular, the formation of chronic pain associated with the pathology of the musculoskeletal system.

About the authors

Taras S. Panevin

Nasonova Research Institute of Rheumatology

Author for correspondence.
Email: tarasel@list.ru
ORCID iD: 0000-0002-5290-156X

канд. мед. наук, науч. сотр. лаб. эволюции ревматоидного артрита, врач-эндокринолог

Russian Federation, Moscow

Anastasia O. Bobkova

Nasonova Research Institute of Rheumatology

Email: tarasel@list.ru
ORCID iD: 0000-0002-9958-8988

врач-ординатор

Russian Federation, Moscow

Andrey E. Karateev

Nasonova Research Institute of Rheumatology

Email: tarasel@list.ru
ORCID iD: 0000-0002-1391-0711

нач. отд. воспалительных заболеваний суставов

Russian Federation, Moscow

Evgeniy G. Zotkin

Nasonova Research Institute of Rheumatology

Email: tarasel@list.ru
ORCID iD: 0000-0002-4579-2836

д-р мед. наук, первый зам. дир.

Russian Federation, Moscow

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