Sub-analyses of the DAPA-CKD study: new data on the use of sodium-glucose cotransporter type 2 inhibitor in the treatment of chronic kidney disease

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Abstract

Sodium-glucose cotransporter inhibitors updated their position in the therapy of patients with type 2 diabetes mellitus due to proven nephro- and cardioprotective effects. The DAPA-CKD study, performed among individuals with CKD of various etiologies, was also conducted in a mixed population, including patients without type 2 diabetes, showed the ability of dapagliflozin to reduce the risk of the primary combined endpoint (eGFR<15 ml/min/1.73 m2, the need for chronic dialysis or kidney transplantation, time to renal or cardiovascular death), and certain secondary endpoints. Due to the inclusion of dapagliflozin into the treatment of the patients with CKD of not only the diabetic origin and the expected subsequent significant expansion of the patient population with indications for the use of this drug, the review of the results of the sub-analyses of DAPA-CKD study may be of interest to the clinicians.

About the authors

Minara S. Shamkhalova

Endocrinology Research Centre

Email: shamkhalova@mail.ru
ORCID iD: 0000-0002-3433-0142

д-р мед. наук, зав. отделением диабетической болезни почек и посттрансплантационной реабилитации

Russian Federation, Moscow

Olga Y. Sukhareva

National Medical Research Center for Endocrinology

Author for correspondence.
Email: olgasukhareva@mail.ru
ORCID iD: 0000-0002-3443-7206

канд. мед. наук, ведущий научный сотрудник отделения диабетической болезни почек и посттрансплантационной реабилитации

Russian Federation, Moscow

Marina V. Shestakova

Endocrinology Research Centre

Email: nephro@endocrincentr.ru
ORCID iD: 0000-0002-5057-127X

акад. РАН, д-р мед. наук, проф., зав. каф. диабетологии и диетологии, дир. Института диабета, зам. дир.

Russian Federation, Moscow

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Supplementary files

Supplementary Files
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1. JATS XML
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2. Fig. 1. The treatment effect of dapagliflozin compared with placebo as a function of baseline HbA1c (continuous) for the primary outcome [8].

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3. Fig. 2. The primary and secondary outcomes in participants with and without diabetes [15].

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4. Fig. 3. The primary and secondary outcomes by kidney disease diagnosis at baseline [15].

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5. Fig. 4. The primary, secondary and pre-specified exploratory endpoints outcomes according to baseline heart failure status [19].

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6. Fig. 5. The primary and secondary endpoints outcomes according to baseline cardiovascular disease status [20].

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7. Fig. 6. Change in eGFR in the DAPA-CKD study in participants with baseline stage 4 or stage 2/3 of chronic kidney disease [23].

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