Epithelial protective therapy in comorbid diseases. Practical Guidelines for Physicians

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Abstract

This document was produced with the support of the National Medical Association for the Study of Comorbidities (NASС).

In 2021 the first multidisciplinary National Consensus on the pathophysiological and clinical aspects of Increased Epithelial Permeability Syndrome was published. The proposed guidelines are developed on the basis of this Consensus, by the same team of experts. Twenty-eight Practical Guidelines for Physicians statements were adopted by the Expert Council using the "delphic" method. Such main groups of epithelial protective drugs as proton pump inhibitors, bismuth drugs and probiotics are discussed in these Guidelines from the positions of evidence-based medicine. The clinical and pharmacological characteristics of such a universal epithelial protector as rebamipide, acting at the preepithelial, epithelial and subepithelial levels, throughout gastrointestinal tract, are presented in detail.

About the authors

Vladimir I. Simanenkov

Mechnikov North-Western State Medical University

Author for correspondence.
Email: visimanenkov@mail.ru
ORCID iD: 0000-0002-1956-0070

д-р мед. наук, проф., проф. каф. внутренних болезней, клинической фармакологии и нефрологии ФГБОУ ВО «СЗГМУ им. И.И. Мечникова»

Russian Federation, Saint Petersburg

Igor V. Maev

Yevdokimov Moscow State University of Medicine and Dentistry

Email: visimanenkov@mail.ru
ORCID iD: 0000-0001-6114-564X

акад. РАН, д-р мед. наук, проф., зав. каф. пропедевтики внутренних болезней и гастроэнтерологии лечебного фак-та ФГБОУ ВО «МГМСУ им. А.И. Евдокимова»

Russian Federation, Moscow

Olga N. Tkacheva

Russian Clinical and Research Center of Gerontology of Pirogov Russian National Research Medical University

Email: visimanenkov@mail.ru
ORCID iD: 0000-0002-4193-688X

д-р мед. наук, проф., дир. ОСП РГНКЦ ФГАОУ ВО «РНИМУ им. Н.И. Пирогова»

Russian Federation, Moscow

Sergei A. Alekseenko

Far-East State Medical University

Email: visimanenkov@mail.ru
ORCID iD: 0000-0003-1724-9980

д-р мед. наук, проф., зав. каф. госпитальной терапии ФГБОУ ВО ДВГМУ

Russian Federation, Khabarovsk

Dmitry Andreev

Yevdokimov Moscow State University of Medicine and Dentistry

Email: visimanenkov@mail.ru
ORCID iD: 0000-0002-4007-7112

канд. мед. наук, доц., доц. каф. пропедевтики внутренних болезней и гастроэнтерологии ФГБОУ ВО «МГМСУ им. А.И. Евдокимова»

Russian Federation, Moscow

Natalia V. Bakulina

Mechnikov North-Western State Medical University

Email: visimanenkov@mail.ru
ORCID iD: 0000-0003-4075-4096

д-р мед. наук, зав. каф. внутренних болезней, клинической фармакологии и нефрологии ФГБОУ ВО «СЗГМУ им. И.И. Мечникова»

Russian Federation, Saint Petersburg

Igor G. Bakulin

Mechnikov North-Western State Medical University

Email: visimanenkov@mail.ru
ORCID iD: 0000-0002-6151-2021

д-р мед. наук, проф., зав. каф. пропедевтики внутренних болезней, гастроэнтерологии и диетологии ФГБОУ ВО «СЗГМУ им. И.И. Мечникова»

Russian Federation, Saint Petersburg

Dmitry S. Bordin

Yevdokimov Moscow State University of Medicine and Dentistry, , Russia; Loginov Moscow Clinical Scientific Center; Tver State Medical University

Email: visimanenkov@mail.ru
ORCID iD: 0000-0003-2815-3992

д-р мед. наук, проф., проф. каф. пропедевтики внутренних болезней и гастроэнтерологии ФГБОУ ВО «МГМСУ им. А.И. Евдокимова», зав. отд. патологии поджелудочной железы, желчных путей и верхних отделов пищеварительного тракта ГБУЗ «МКНЦ им. А.С. Логинова», проф. каф. поликлинической терапии и семейной медицины ФГБОУ ВО ТГМУ

Russian Federation, Moscow; Moscow; Tver

Timur D. Vlasov

Pavlov First Saint Petersburg State Medical University

Email: visimanenkov@mail.ru
ORCID iD: 0000-0002-6951-7599

д-р мед. наук, проф., зав. каф. патологической физиологии с курсом клинической патофизиологии ФГБОУ ВО «Первый СПб ГМУ им. акад. И.П. Павлова»

Russian Federation, Saint Petersburg

Natalya M. Vorobyeva

Russian Clinical and Research Center of Gerontology of Pirogov Russian National Research Medical University

Email: visimanenkov@mail.ru
ORCID iD: 0000-0002-6021-7864

д-р мед. наук, зав. лаб. сердечно-сосудистого старения ОСП РГНКЦ ФГАОУ ВО «РНИМУ им. Н.И. Пирогова»

Russian Federation, Moscow

Vladimir B. Grinevich

Kirov Military Medical Academy

Email: visimanenkov@mail.ru
ORCID iD: 0000-0002-1095-8787

д-р мед. наук, проф., зав. 2-й каф. терапии (усовершенствования врачей) ФГБВОУ ВО «ВМА им. С.М. Кирова»

Russian Federation, Saint Petersburg

Irina V. Gubonina

Kirov Military Medical Academy

Email: visimanenkov@mail.ru
ORCID iD: 0000-0002-6302-7767

канд. мед. наук, доц. 2 каф. терапии (усовершенствования врачей) ФГБВОУ ВО «ВМА им. С.М. Кирова»

Russian Federation, Saint Petersburg

Michail Y. Drobizhev

Semashko National Research Institute of Public Health

Email: visimanenkov@mail.ru
ORCID iD: 0000-0002-1536-219X

д-р мед. наук, вед. науч. сотр. отд. изучения образа жизни и охраны здоровья населения ФГБНУ «Национальный НИИ общественного здоровья им. Н.А. Семашко»

Russian Federation, Moscow

Nikolay S. Efremov

Russian Clinical and Research Center of Gerontology of Pirogov Russian National Research Medical University; Pirogov Russian National Research Medical University

Email: visimanenkov@mail.ru
ORCID iD: 0000-0001-7785-3405

канд. мед. наук, доц., врач-уролог ОСП РГНКЦ ФГАОУ ВО «РНИМУ им. Н.И. Пирогова», доц. каф. урологии и андрологии ФГАОУ ВО «РНИМУ им. Н.И. Пирогова»

Russian Federation, Moscow; Moscow

Andrey E. Karateev

Nasonova Research Institute of Rheumatology

Email: visimanenkov@mail.ru
ORCID iD: 0000-0002-1391-0711

д-р мед. наук, проф., зав. лаб. патофизиологии боли и клинического полиморфизма скелетно-мышечных заболеваний ФГБНУ «НИИ ревматологии им. В.А. Насоновой»

Russian Federation, Moscow

Yulia V. Kotovskaya

Russian Clinical and Research Center of Gerontology of Pirogov Russian National Research Medical University

Email: visimanenkov@mail.ru
ORCID iD: 0000-0002-1628-5093
Russian Federation, Moscow

Iurii Kravchuk

Kirov Military Medical Academy

Email: visimanenkov@mail.ru
ORCID iD: 0000-0001-8347-0531

д-р мед. наук, проф., проф. 2 каф. терапии (усовершенствования врачей) ФГБВОУ ВО «ВМА им. С.М. Кирова»

Russian Federation, Saint Petersburg

Grigory G. Krivoborodov

Russian Clinical and Research Center of Gerontology of Pirogov Russian National Research Medical University; Pirogov Russian National Research Medical University

Email: visimanenkov@mail.ru
ORCID iD: 0000-0001-6433-4219

д-р мед. наук, зав. отд-нием урологии ОСП РГНКЦ ФГАОУ ВО «РНИМУ им. Н.И. Пирогова», проф. каф. урологии и андрологии ФГАОУ ВО «РНИМУ им. Н.И. Пирогова»

Russian Federation, Moscow; Moscow

Ekaterina V. Kulchavenya

Novosibirsk Research Institute of Tuberculosis; Novosibirsk State Medical University

Email: visimanenkov@mail.ru
ORCID iD: 0000-0001-8062-7775

д-р мед. наук, проф., гл. науч. сотр. ФГБУ «Новосибирский НИИ туберкулеза», рук. отд. урологии, проф. каф. туберкулеза ФГБОУ ВО НГМУ

Russian Federation, Novosibirsk; Novosibirsk

Aleksander M. Lila

Nasonova Research Institute of Rheumatology; Russian Medical Academy of Continuous Professional Education

Email: visimanenkov@mail.ru
ORCID iD: 0000-0002-6068-3080

д-р мед. наук, проф., дир. ФГБНУ «НИИ ревматологии им. В.А. Насоновой», зав. каф. ревматологии ФГБОУ ДПО РМАНПО

Russian Federation, Moscow; Moscow

Marina V. Maevskaya

Sechenov First Moscow State Medical University (Sechenov University)

Email: visimanenkov@mail.ru
ORCID iD: 0000-0001-8913-140X

д-р мед. наук, проф., консультант ЛДО №3 Университетской клинической больницы №2 ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова» (Сеченовский Университет)

Russian Federation, Moscow

Anna S. Nekrasova

Mechnikov North-Western State Medical University

Email: visimanenkov@mail.ru
ORCID iD: 0000-0001-5198-9902

канд. мед. наук, доц. каф. внутренних болезней, клинической фармакологии и нефрологии ФГБОУ ВО «СЗГМУ им. И.И. Мечникова»

Russian Federation, Saint Petersburg

Elena A. Poluektova

Sechenov First Moscow State Medical University (Sechenov University)

Email: visimanenkov@mail.ru
ORCID iD: 0000-0003-1312-120X

д-р мед. наук, проф. каф. пропедевтики внутренних болезней гастроэнтерологии и гепатологии Института клинической медицины им. Н.В. Склифосовского ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова» (Сеченовский Университет)

Russian Federation, Moscow

Tatiana V. Popkova

Nasonova Research Institute of Rheumatology

Email: visimanenkov@mail.ru
ORCID iD: 0000-0001-5793-4689

д-р мед. наук, зав. лаб. системных ревматических заболеваний ФГБНУ «НИИ ревматологии им. В.А. Насоновой»

Russian Federation, Moscow

Oleg A. Sablin

Nikiforov All-Russian Center for Emergency and Radiation Medicine

Email: visimanenkov@mail.ru
ORCID iD: 0000-0002-2597-1220

д-р мед. наук, проф., зав. клин. отд. терапии и профпатологии Клиники №1, проф. каф. терапии Института дополнительного профессионального образования «Экстремальная медицина» ФГБУ «ВЦЭРМ им. А.М. Никифорова»

Russian Federation, Saint Petersburg

Olga I. Solovyeva

Mechnikov North-Western State Medical University

Email: visimanenkov@mail.ru
ORCID iD: 0000-0003-0037-7855

канд. мед. наук, доц. каф. внутренних болезней, клинической фармакологии и нефрологии ФГБОУ ВО «СЗГМУ им. И.И. Мечникова»

Russian Federation, Saint Petersburg

Alexander N. Suvorov

Institute of Experimental Medicine

Email: visimanenkov@mail.ru
ORCID iD: 0000-0003-2312-5589

чл.-кор. РАН, д-р мед. наук, проф., зав. каф. фундаментальных проблем медицины и медицинских технологий фак-та стоматологии и медицинских технологий СПбГУ, зав. отд. молекулярной микробиологии ФГБНУ ИЭИ

Russian Federation, Saint Petersburg

Galina N. Tarasova

Rostov State Medical University

Email: visimanenkov@mail.ru
ORCID iD: 0000-0003-4054-9180

д-р мед. наук, проф., проф. каф. внутренних болезней ФГБОУ ВО РостГМУ

Russian Federation, Rostov on Don

Dmity I. Trukhan

Omsk State Medical University

Email: visimanenkov@mail.ru
ORCID iD: 0000-0002-1597-1876

д-р мед. наук, проф. каф. поликлинической терапии и внутренних болезней ФГБОУ ВО ОмГМУ

Russian Federation, Omsk

Anastasia V. Fedotova

Pirogov Russian National Research Medical University

Email: visimanenkov@mail.ru
ORCID iD: 0000-0002-2627-0485

канд. мед. наук, доц. каф. неврологии фак-та усовершенствования врачей ФГАОУ ВО «РНИМУ им. Н.И. Пирогова»

Russian Federation, Moscow

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