Pancreatic cancer risk: alcoholic and non-alcoholic beverages
- Authors: Grigor’eva I.N.1
-
Affiliations:
- Institute of Internal and Preventive Medicine – branch of the Institute of Cytology and Genetics
- Issue: Vol 94, No 2 (2022)
- Pages: 265-270
- Section: Reviews
- URL: https://journals.rcsi.science/0040-3660/article/view/105595
- DOI: https://doi.org/10.26442/00403660.2022.02.201375
- ID: 105595
Cite item
Full Text
Abstract
This article provides an overview of the metaanalyzes (PubMed, 1995–2019) of alcohol and non-alcoholic (coffee, tea, dairy products) beverage consumption in relation to risk of pancreatic cancer – PC (PubMed, 1995–2019). Increased the PC risk was associated with high alcohol intake. The increased risk for heavy drinking did not explained by residual confounding by history of pancreatitis or tobacco smoking or diabetes. Light-moderate alcohol intake may reduced the PC risk, probably due to the fasting insulin levels decrement, which leads to the diminished the РС risk. The association between alcohol and the PC was stronger in men than in women. Some metaanalyzes demonstrated that a small amount of coffee may reduce PC risk, and a large amount – to increase PC risk. Another meta-analyzes have not confirmed any association between the PC risk and coffee or tea consumption. One meta-analysis revealed a direct association of the PC risk with the dairy products consumption, but most research showed no such connection. Nutrition is considered to be associated with the PC risk, but the degree of risk due to structure of beverages consumption (dose, duration, alcohol, coffee, tea, dairy products pattern) is still not clear.
Keywords
Full Text
##article.viewOnOriginalSite##About the authors
Irina N. Grigor’eva
Institute of Internal and Preventive Medicine – branch of the Institute of Cytology and Genetics
Author for correspondence.
Email: igrigorieva@ngs.ru
ORCID iD: 0000-0003-0069-7744
д-р мед. наук, проф., гл. науч. сотр. лаб. гастроэнтерологии
Russian Federation, NovosibirskReferences
- Ferlay J, Soerjomataram I, Dikshit R, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015;136(5):E359-86. doi: 10.1002/ijc.29210
- Григорьева И.Н., Ефимова О.В., Суворова Т.С., Тов Н.Л. Панкреатит, рак поджелудочной железы и ожирение: гипотезы и факты. Экспериментальная и клиническая гастроэнтерология. 2014;9:4-10 [Grigor’eva IN, Efimova OV, Suvorova TS, Tov NL. Pancreatitis, pancreatic cancer and obesity: hypothesis and facts. Eksperimental'naia i klinicheskaia gastroenterologiia. 2014;9:4-10 (in Russian)].
- Eibl G, Cruz-Monserrate Z, Korc M, et al. Diabetes Mellitus and Obesity as Risk Factors for Pancreatic Cancer. J Acad Nutr Diet. 2018;118(4):555-67. doi: 10.1016/j.jand.2017.07.005
- Романова Т.И., Григорьева И.Н., Ефимова О.В. Рак поджелудочной железы. Некоторые молекулярные и генетические механизмы онкогенеза как мишень для терапии. Экспериментальная и клиническая гастроэнтерология. 2017;2:103-109 [Romanova TI, Grigor’eva IN, Efimova OV. Cancer of the pancreas. Some of the molecular and genetic mechanisms of carcinogenesis as a target for therapy. Eksperimental'naia i klinicheskaia gastroenterologiia. 2017;2:103-9 (in Russian)].
- Meadows GG, Zhang H. Effects of Alcohol on Tumor Growth, Metastasis, Immune Response, and Host Survival. Alcohol Res. 2015; 37(2):311-22.
- Cuomo R, Andreozzi P, Zito FP. Alcoholic beverages and carbonated soft drinks: consumption and gastrointestinal cancer risks. Cancer Treat Res. 2014;159:97-120. doi: 10.1007/978-3-642-38007-5_7
- Duell EJ. Epidemiology and potential mechanisms of tobacco smoking and heavy alcohol consumption in pancreatic cancer. Mol Carcinog. 2012;51(1):40-52. doi: 10.1002/mc.20786
- Seitz HK, Stickel F. Molecular mechanisms of alcohol-mediated carcinogenesis. Nat Rev Cancer. 2007;7(8):599-612. doi: 10.1038/nrc2191
- Hamid A, Wani NA, Kaur J. New perspectives on folate transport in relation to alcoholism-induced folate malabsorption – association with epigenome stability and cancer development. FEBS J. 2009;276(8):2175-91. doi: 10.1111/j.1742-4658.2009.06959.x
- Huang X, Li X, Ma Q, et al. Chronic alcohol exposure exacerbates inflammation and triggers pancreatic acinar-to-ductal metaplasia through PI3K/Akt/IKK. Int J Mol Med. 2015;35(3):653-63. doi: 10.3892/ijmm.2014.2055
- Irving HM, Samokhvalov AV, Rehm J. Alcohol as a risk factor for pancreatitis. A systematic review and meta-analysis. JOP. 2009;10(4):387-92.
- Valean S, Chira R, Dumitrascu D. Epidemiological trends in digestive cancers in Romania, 1955-2012, compared to alcohol consumption. Correlation or coincidence? Clujul Med. 2018;91(4):376-86. doi: 10.15386/cjmed-1067
- Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003; 327(7414):557-60. doi: 10.1136/bmj.327.7414.557
- Wang YT, Gou YW, Jin WW, et al. Association between alcohol intake and the risk of pancreatic cancer: a dose-response meta-analysis of cohort studies. BMC Cancer. 2016;16:212. doi: 10.1186/s12885-016-2241-1
- Li Y, Yang H, Cao J. Association between alcohol consumption and cancers in the Chinese population – a systematic review and meta-analysis. PLoS One. 2011;6(4):e18776. doi: 10.1371/journal.pone.0018776
- Pang Y, Holmes MV, Guo Y, et al. Smoking, alcohol, and diet in relation to risk of pancreatic cancer in China: a prospective study of 0.5 million people. Cancer Med. 2018;7(1):229-39. doi: 10.1002/cam4.1261
- Massoneuve P, Lowenfels AB. Risk factors for pancreatic cancer: a summary review of meta-analytical studies. Int J Epidemiol. 2015;44(1):186-98. doi: 10.1093/ije/dyu240
- Michaud DS, Giovannucci E, Willett WC, et al. Coffee and alcohol consumption and the risk of pancreatic cancer in two prospective United States cohorts. Cancer Epidemiol Biomarkers Prev. 2001;10(5):429-37.
- Haugvik SP, Hedenström P, Korsæth E, et al. Diabetes, smoking, alcohol use, and family history of cancer as risk factors for pancreatic neuroendocrine tumors: a systematic review and meta-analysis. Neuroendocrinology. 2015;101(2):133-42. doi: 10.1159/000375164
- Bagnardi V, Blangiardo M, La Vecchia C, Corrao G. A meta-analysis of alcohol drinking and cancer risk. Br J Cancer. 2001;85(11):1700-05. doi: 10.1054/bjoc.2001.2140
- Bagnardi V, Rota M, Botteri E, et al. Alcohol consumption and site-specific cancer risk: a comprehensive dose–response meta-analysis. Br J Cancer. 2015;112(3):580-93. doi: 10.1038/bjc.2014.579
- Lazarus R, Sparrow D, Weiss ST. Alcohol intake and insulin levels: The Normative Aging Study. Am J Epidemiol. 1997;145:909-16. doi: 10.1093/oxfordjournals.aje.a009050
- Gupta S, Wang F, Holly EA, Bracci PM. Risk of pancreatic cancer by alcohol dose, duration, and pattern of consumption, including binge drinking: a population-based study. Cancer Causes Control. 2010;21(7):1047-59. doi: 10.1007/s10552-010-9533-6
- Tramacere I, Scotti L, Jenab M, et al. Alcohol drinking and pancreatic cancer risk: a meta-analysis of the dose-risk relation. Int J Cancer. 2010;126(6):1474-86. doi: 10.1002/ijc.24936
- Welsch T, Kleeff J, Seitz HK, et al. Update on pancreatic cancer and alcohol-associated risk. J Gastroenterol Hepatol. 2006;21(3):S69-75.
- Genkinger JM, Spiegelman D, Anderson KE, et al. Alcohol intake and pancreatic cancer risk: a pooled analysis of fourteen cohort studies. Cancer Epidemiol Biomarkers Prev. 2009;18(3):765-76. doi: 10.1158/1055-9965.EPI-08-0880
- Pourhoseingholi MA, Ashtari S, Hajizadeh N, et al. Systematic review of pancreatic cancer epidemiology in Asia-Pacific Region: major patterns in GLOBOCAN 2012. Gastroenterol Hepatol Bed Bench. 2017;10(4):245-257.
- Ratna A, Mandrekar P. Alcohol and Cancer: Mechanisms and Therapies. Biomolecules. 2017;7(3):E61. doi: 10.3390/biom7030061
- Dong J, Zou J, Yu XF. Coffee drinking and pancreatic cancer risk: a meta-analysis of cohort studies. World J Gastroenterol. 2011;17(9):1204-10. doi: 10.3748/wjg.v17.i9.1204
- Grigorieva IN. Pancreatic cancer risk factors: a summary review of meta-analytical and prospective cohort studies. Coffee and tea consumption. Экспериментальная и клиническая гастроэнтерология. 2018;3:93-96.
- Nie K, Xing Z, Huang W, et al. Coffee intake and risk of pancreatic cancer: an updated meta-analysis of prospective studies. Minerva Med. 2016;107(4):270-8.
- Ran HQ, Wang JZ, Sun CQ. Coffee Consumption and Pancreatic Cancer Risk: An Update Meta-analysis of Cohort Studies. Pak J Med Sci. 2016;32(1):253-9. doi: 10.12669/pjms.321.8761
- Nishi M, Ohba S, Hirata K, Miyake H. Dose-response Relationship Between Coffee and the Risk of Pancreas Cancer. Jpn J Clin Oncol. 1996;26(1):42-8. doi: 10.1093/oxfordjournals.jjco.a023177
- Bidel S, Hu G, Jousilahti P, et al. Coffee consumption and risk of gastric and pancreatic cancer – a prospective cohort study. Int J Cancer. 2013;132(7):1651-9. doi: 10.1002/ijc.27773
- Guertin KA, Freedman ND, Loftfield E, et al. A prospective study of coffee intake and pancreatic cancer: results from the NIH-AARP Diet and Health Study. Br J Cancer. 2015;113(7):1081-85. doi: 10.1038/bjc.2015.235
- Zhou CD, Kuan AS, Reeves GK, et al. Coffee and pancreatic cancer risk among never-smokers in the UK prospective Million Women Study. Int J Cancer. 2019;145(6):1484-92. doi: 10.1002/ijc.31994
- Bhoo-Pathy N, Uiterwaal CS, Dik VK, et al. Intake of coffee, decaffeinated coffee, or tea does not affect risk for pancreatic cancer: results from the European Prospective Investigation into Nutrition and Cancer Study. Clin Gastroenterol Hepatol. 2013;11(11):1486-92. doi: 10.1016/j.cgh.2013.05.029
- Turati F, Galeone C, Edefonti V, et al. A meta-analysis of coffee consumption and pancreatic cancer. Ann Oncol. 2012;23(2):311-8. doi: 10.1093/annonc/mdr331
- Sanikini H, Dik VK, Siersema PD, et al. Total, caffeinated and decaffeinated coffee and tea intake and gastric cancer risk: results from the EPIC cohort study. Int J Cancer. 2015;136(6):E720-30. doi: 10.1002/ijc.29223
- Berretta M, Micek A, Lafranconi A, et al. Coffee consumption is not associated with ovarian cancer risk: a dose-response meta-analysis of prospective cohort studies. Oncotarget. 2018;9(29):20807-815. doi: 10.18632/oncotarget.24829
- Wang A, Wang S, Zhu C, et al. Coffee and cancer risk: A meta-analysis of prospective observational studies. Sci Rep. 2016;6:33711. doi: 10.1038/srep33711
- Gullo L, Pezzilli R, Morselli-Labate AM. Coffee and cancer of the pancreas: an Italian multicenter study. Pancreas. 1995;11(3):223-9. doi: 10.1097/00006676-199510000-00002
- Li TD, Yang HW, Wang P, et al. Coffee consumption and risk of pancreatic cancer: a systematic review and dose-response meta-analysis. Int J Food Sci Nutr. 2019;70(5):519-21. doi: 10.1080/09637486.2018.1551337
- Nilsson LM, Johansson I, Lenner P, et al. Consumption of filtered and boiled coffee and the risk of incident cancer: a prospective cohort study. Cancer Causes Control. 2010;21(10):1533-44. doi: 10.1007/s10552-010-9582-x
- Lukic M, Nilsson LM, Skeie G, et al. Coffee consumption and risk of rare cancers in Scandinavian countries. Eur J Epidemiol. 2018;33(3):287-302. doi: 10.1007/s10654-018-0369-9
- Poole R, Kennedy OJ, Roderick P, et al. Coffee consumption and health: umbrella review of meta-analyses of multiple health outcomes. BMJ. 2017;359:j5024. doi: 10.1136/bmj.j5024
- Takada M, Nakamura Y, Koizumi T, et al. Suppression of human pancreatic carcinoma cell growth and invasion by epigallocatechin-3-gallate. Pancreas. 2002;25:45-8. doi: 10.1097/00006676-200207000-00012
- Zheng JS, Yang J, Fu YQ, et al. Effects of green tea, black tea, and coffee consumption on the risk of esophageal cancer: a systematic review and meta-analysis of observational studies. Nutr Cancer. 2013;65(1):1-16. doi: 10.1080/01635581.2013.741762
- Kang H, Rha SY, Oh KW, Nam CM. Green tea consumption and stomach cancer risk: a meta-analysis. Epidemiol Health. 2010;32:e2010001. doi: 10.4178/epih/e2010001
- Huang YQ, Lu X, Min H, et al. Green tea and liver cancer risk: A meta-analysis of prospective cohort studies in Asian populations. Nutrition. 2016;32(1):3-8. doi: 10.1016/j.nut.2015.05.021
- Tang J, Zheng JS, Fang L, et al. Tea consumption and mortality of all cancers, CVD and all causes: a meta-analysis of eighteen prospective cohort studies. Br J Nutr. 2015;114(5):673-83. doi: 10.1017/S0007114515002329
- Zhang YF, Xu Q, Lu J, et al. Tea consumption and the incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Eur J Cancer Prev. 2015;24(4):353-62. doi: 10.1097/CEJ.0000000000000094
- Zeng JL, Li ZH, Wang ZC, Zhang HL. Green tea consumption and risk of pancreatic cancer: a meta-analysis. Nutrients. 2014;6(11):4640-50. doi: 10.3390/nu6114640
- Chang B, Sang L, Wang Y, et al. Consumption of tea and risk for pancreatic cancer: a meta-analysis of published epidemiological studies. Nutr Cancer. 2014;66(7):1109-23. doi: 10.1080/01635581.2014.951730
- Chen K, Zhang Q, Peng M, et al. Relationship between tea consumption and pancreatic cancer risk: a meta-analysis based on prospective cohort studies and case-control studies. Eur J Cancer Prev. 2014;23(5):353-60. doi: 10.1097/CEJ.0000000000000033
- Boehm K, Borrelli F, Ernst E, et al. Green tea (Camellia sinensis) for the prevention of cancer. Cochrane Database Syst Rev. 2009;3. doi: 10.1002/14651858.CD005004
- Lin Y, Tamakoshi A, Kikuchi S, et al. Serum insulin-like growth factor-I, insulin-like growth factor binding protein-3, and the risk of pancreatic cancer death. Int J Cancer. 2004;110:584-8. doi: 10.1002/ijc.20147
- Thiébaut AC, Jiao L, Silverman DT, et al. Dietary fatty acids and pancreatic cancer in the NIH-AARP diet and health study. J Natl Cancer Inst. 2009;101(14):1001-111. doi: 10.1093/jnci/djp168
- Genkinger JM, Wang M, Li R, et al. Dairy products and pancreatic cancer risk: a pooled analysis of 14 cohort studies. Ann Oncol. 2014; 25(6):1106-15. doi: 10.1093/annonc/mdu019
- Lu PY, Shu L, Shen SS, et al. Dietary Patterns and Pancreatic Cancer Risk: A Meta-Analysis. Nutrients. 2017;9(1):38. doi: 10.3390/nu9010038
![](/img/style/loading.gif)