Venous thromboembolic complications in patients with chronic kidney disease: prevalence and features of drug treatment

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Abstract

The article is an opinion on the problem of venous thromboembolic (VTE) complications in patients with chronic kidney disease (CKD), which is significant and urgent for Russia. Signs of CKD are noted in more than 1/3 of patients with chronic heart failure; a decrease in kidney function is observed in 36% of people over the age of 60, in people of working age, a decrease in function is noted in 16% of cases, and in the presence of cardiovascular diseases increases to 26%. Clinical research data convincingly show that CKD is an independent risk factor for the development of VTE complications. The last decade has given us the opportunity to observe a kind of "revolution" in VTE therapy, which is associated with the appearance on the market of direct oral anticoagulants, including inhibitors of factor IIa (thrombin) and factor Xa. These drugs are approved by the Food and Drug Administration for the treatment of acute thromboembolism. Nevertheless, patients with severe CKD (estimated glomerular filtration rate <30 ml/min) are still limited to the use of unfractionated heparin and vitamin K antagonists, as there is insufficient data to support the use of direct oral anticoagulants in this population.

About the authors

Olga N. Dzhioeva

National Research Center for Therapy and Preventive Medicine; Yevdokimov Moscow State University of Medicine and Dentistry

Author for correspondence.
Email: dzhioevaon@gmail.com
ORCID iD: 0000-0002-5384-3795

д-р мед. наук, вед. науч. сотр. отд. фундаментальных и прикладных аспектов ожирения ФГБУ НМИЦ ТПМ, проф. каф. терапии и профилактической медицины ФГБОУ ВО «МГМСУ им. А.И. Евдокимова»

Russian Federation, Moscow; Moscow

Anna A. Orlova

National Research Center for Therapy and Preventive Medicine

Email: dzhioevaon@gmail.com
ORCID iD: 0000-0002-6365-5261

мл. науч. сотр. отд. фундаментальных и прикладных аспектов ожирения

Russian Federation, Moscow

Elizaveta A. Rogozhkina

National Research Center for Therapy and Preventive Medicine

Email: dzhioevaon@gmail.com
ORCID iD: 0000-0001-8993-7892

клин. ординатор

Russian Federation, Moscow

Oksana M. Drapkina

National Research Center for Therapy and Preventive Medicine; Yevdokimov Moscow State University of Medicine and Dentistry

Email: dzhioevaon@gmail.com
ORCID iD: 0000-0002-4453-8430

чл.-кор. РАН, д-р мед. наук, проф., дир. ФГБУ НМИЦ ТПМ, зав. каф. терапии и профилактической медицины ФГБОУ ВО «МГМСУ им. А.И. Евдокимова»

Russian Federation, Moscow; Moscow

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