The incidence of cardiovascular and cerebrovascular complications in patients with uncontrolled hypertension
- Authors: Denisova A.R.1, Solntseva T.D.1, Zarmanbetova A.S.1, Tkacheva A.A.1, Sivakova O.A.1, Chazova I.Е.1
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Affiliations:
- National Medical Research Center of Cardiology
- Issue: Vol 94, No 1 (2022)
- Pages: 94-99
- Section: Original articles
- URL: https://journals.rcsi.science/0040-3660/article/view/104772
- DOI: https://doi.org/10.26442/00403660.2022.01.201395
- ID: 104772
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Abstract
Aim. To assess the incidence of cardiovascular and cerebrovascular events in patients with controlled and uncontrolled hypertension, controlled resistant and uncontrolled resistant hypertension, refractory hypertension, and probably resistant and probably refractory hypertension.
Materials and methods. A telephone call was made to 256 patients with hypertension included in the database to assess the incidence of cardiovascular and cerebrovascular diseases. All responding patients were divided into 7 groups according to the classification of hypertension based on the achievement/non-achievement of target blood pressure values and the number of drugs taken (controlled and uncontrolled hypertension, controlled resistant and uncontrolled resistant hypertension, refractory hypertension, and probably resistant and probably refractory hypertension). The target blood pressure was considered to be less than 140/90 mm Hg. Patients not adhering to medication were not included in the analysis.
Results. The group of controlled hypertension included 146 (57%) patients out of 256, controlled resistant hypertension – 36 (14%) patients, uncontrolled hypertension – 6 (2.3%) patients, resistant uncontrolled hypertension – 22 (8.6%) patients, refractory hypertension – 31 (12.1%) patients. The group of probably resistant hypertension – 6 (2.3%) patients, probably refractory hypertension – 9 (3.5%) patients. Of the 28 events that occurred, 6 were attributed to coronary artery disease (including 3 acute myocardial infarction and 2 coronary artery stenting), 3 strokes, 6 episodes of transient ischemic attack and 10 new cases of atrial fibrillation, and 2 patients had sudden cardiac death. Significantly more often, patients with refractory hypertension developed any event compared with patients with controlled (38.7% versus 3.4%; p=0.005) and resistant hypertension (38.7% versus 13.6%; p=0.04). Also, patients from the group of probably refractory hypertension were more likely to develop events than patients with controlled hypertension (33.3% versus 3.4%; p=0.045). Patients with probably refractory hypertension significantly more often had a stroke than patients with controlled hypertension (22.2% versus 0%; p<0.05), and patients with refractory hypertension significantly more often had a transient ischemic attack compared with patients from the group of controlled hypertension (12.9% versus 0.7%; p=0.03).
Conclusion. Patients with refractory and probably refractory hypertension are significantly more likely to develop cardiovascular and cerebrovascular complications than patients with controlled hypertension.
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##article.viewOnOriginalSite##About the authors
Anastasiya R. Denisova
National Medical Research Center of Cardiology
Author for correspondence.
Email: nastya4358@gmail.com
ORCID iD: 0000-0003-2686-3026
врач-кардиолог 5-го клин. отд-ния (отд. гипертонии) Института клинической кардиологии им. А.Л. Мясникова
Russian Federation, MoscowTatyana D. Solntseva
National Medical Research Center of Cardiology
Email: nastya4358@gmail.com
ORCID iD: 0000-0002-7381-7818
клин. ординатор 5-го клин. отд-ния (отд. гипертонии) Института клинической кардиологии им. А.Л. Мясникова
Russian Federation, MoscowAihanum S. Zarmanbetova
National Medical Research Center of Cardiology
Email: nastya4358@gmail.com
ORCID iD: 0000-0002-7097-4391
клин. ординатор 5-го клин. отд-ния (отд. гипертонии) Института клинической кардиологии им. А.Л. Мясникова
Russian Federation, MoscowAlina A. Tkacheva
National Medical Research Center of Cardiology
Email: nastya4358@gmail.com
ORCID iD: 0000-0002-5720-0279
клин. ординатор 5-го клин. отд-ния (отд. гипертонии) Института клинической кардиологии им. А.Л. Мясникова
Russian Federation, MoscowOlga A. Sivakova
National Medical Research Center of Cardiology
Email: nastya4358@gmail.com
ORCID iD: 0000-0002-0060-095X
канд. мед. наук, зав. отд-нием, врач-кардиолог 5-го клин. отд-ния (отд. гипертонии) Института клинической кардиологии им. А.Л. Мясникова
Russian Federation, MoscowIrina Е. Chazova
National Medical Research Center of Cardiology
Email: nastya4358@gmail.com
ORCID iD: 0000-0002-9822-4357
акад. РАН, д-р мед. наук, проф., зам. ген. дир. по научно-экспертной работе, рук. отд. гипертонии Института клинической кардиологии им. А.Л. Мясникова
Russian Federation, MoscowReferences
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