Assessment of factors affecting the probability of hospitalization of COVID-19 patients with concomitant pathology and development of a prognostic model based on them

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Abstract

Introduction. Currently, a significant number of patients with COVID-19 require inpatient treatment. At the same time, predictors of hospitalization are still stable, including in persons with concomitant pathology.

Aim. Assessment of factors affecting the probability of hospitalization of COVID-19 patients with concomitant pathology and the development of a prognostic model based on them.

Materials and methods. An observational retrospective cohort study of 74 314 patients with COVID-19 with various comorbidities was carried out in the period from March to November 2020 in the Russian Federation.

Results. Based on 16 factors, including age, gender, place of diagnosis, fever, rhinitis, loss of taste, shortness of breath, concomitant diseases of the cardiovascular, bronchopulmonary system, oncological, endocrine diseases in patients included in the study, a prognostic model was developed. The need for inpatient treatment of patients with COVID-19 and comorbidities was determined.

Conclusion. The constructed predictive model has demonstrated sufficient efficiency to assess the likelihood of hospitalization of patients with COVID-19 by medical specialists.

About the authors

Irina A. Lizinfeld

National Medical Research Center of Phthisiopulmonology and Infectious Diseases

Author for correspondence.
Email: pshenichnaya@yandex.ru
ORCID iD: 0000-0002-8114-1002

науч. сотр.

Russian Federation, Moscow

Natalia Yu. Pshenichcnaya

Central Research Institute of Epidemiology

Email: pshenichnaya@yandex.ru
ORCID iD: 0000-0003-2570-711X

д-р мед. наук, проф., зам. дир. по клинико-аналитической работе

Russian Federation, Moscow

Liubov E. Parolina

National Medical Research Center of Phthisiopulmonology and Infectious Diseases

Email: pshenichnaya@yandex.ru
ORCID iD: 0000-0003-4365-5894

д-р мед. наук, проф., рук. Центра образования

Russian Federation, Moscow

Grigorii Yu. Zhuravlev

Central Research Institute of Epidemiology

Email: pshenichnaya@yandex.ru
ORCID iD: 0000-0003-2467-7000

ординатор 2-го года по специальности «Инфекционные болезни»

Russian Federation, Moscow

Viktor V. Maleev

Central Research Institute of Epidemiology

Email: pshenichnaya@yandex.ru
ORCID iD: 0000-0001-5748-178X

акад. РАН, д-р мед. наук, проф., советник дир. по научной работе

Russian Federation, Moscow

Vasiliy G. Akimkin

Central Research Institute of Epidemiology

Email: pshenichnaya@yandex.ru
ORCID iD: 0000-0003-4228-9044

акад. РАН, д-р мед. наук, проф., дир.

Russian Federation, Moscow

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Supplementary files

Supplementary Files
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2. Fig. 1. Study design.

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3. Fig. 2. Comparison of age categories in the studied patients.

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4. Fig. 3. Comparison of clinical symptoms in the studied patients.

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5. Fig. 4. ROC-curve characterizing hospitalization of patients from the value of the logistic function P.

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