Selective Deformation of Single Macromolecules and Biomolecular Structures as a Method for Remote Control of Their Properties and Functions for Next-Generation Medicine

Abstract

An innovative nanomechanical strategy for in vivo biomedical applications is reviewed. The strategy is based on the use of complexes of special functionalized magnetic nanoparticles controlled by an external low-frequency nonheating magnetic field as deformation machines. The advantages of the strategy are the possibility of easily achieved nanoscale locality and molecular selectivity of action (at the level of individual macromolecules and macromolecular structures such as liposomes, living cells, cell organelles), multimodality, safety, and a high potential of therapeutic application, in particular, for noninvasive oncotherapy without drugs.